Perinatal Administration of a Selective Serotonin Reuptake Inhibitor Induces Impairments in Reproductive Function and Follicular Dynamics in Female Rat Offspring

Introduction: Up to 10% of pregnant women take antidepressants, of which selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed. Using a rodent model, we investigated the reproductive impacts of perinatal SSRI treatment on reproductive cyclicity and function in female offsp...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2015-10, Vol.22 (10), p.1297-1311
Hauptverfasser:	Moore, C. J., DeLong, N. E., Chan, K. A., Holloway, A. C., Petrik, J. J., Sloboda, D. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Apoptosis - drug effects CLOCK Proteins - genetics CLOCK Proteins - metabolism Embryology Estrus - drug effects Female Fluoxetine - administration & dosage Fluoxetine - toxicity Gene Expression Regulation, Developmental - drug effects Maternal Exposure Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Article Ovarian Follicle - drug effects Ovarian Follicle - metabolism Ovarian Follicle - pathology Phenotype Pregnancy Prenatal Exposure Delayed Effects Rats, Wistar Reproduction - drug effects Reproductive Medicine RNA, Messenger - genetics RNA, Messenger - metabolism Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - toxicity Signal Transduction - drug effects Weaning
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