The role of exoproteases in governing intraneuronal metabolism of botulinum toxin

Botulinum toxin type A has a long duration of action, and thus it can block transmitter release for several weeks to several months. However, little is known about the precise mechanism that accounts for termination of toxin action. Therefore, experiments were done to gauge the effects of aminopepti...

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Veröffentlicht in:	The Protein Journal 2005-04, Vol.24 (3), p.155-165
Hauptverfasser:	Simpson, Lance L, Maksymowych, Andrew B, Kouguchi, Hirokazu, Dubois, Garrett, Bora, Roop S, Joshi, Suresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminopeptidases - metabolism Botulinum Toxins, Type A - chemistry Botulinum Toxins, Type A - genetics Botulinum Toxins, Type A - metabolism Botulinum Toxins, Type A - pharmacology Carboxypeptidases - metabolism Clostridium botulinum Light Models, Molecular Molecular Sequence Data Neuromuscular Junction - drug effects Neuromuscular Junction - physiology Neurons - metabolism Protein Structure, Tertiary Synaptic Transmission - drug effects Synaptic Transmission - physiology Toxins Vegetables
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