Bone calcium turnover during pregnancy and lactation in women with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations
BACKGROUND: Few data exist on longitudinal changes in bone calcium turnover rates across pregnancy and lactation. OBJECTIVE: Our aim was to characterize calcium kinetic variables and predictors of these changes across pregnancy and early lactation in women with low calcium intakes. DESIGN: Stable ca...
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| Veröffentlicht in: | The American journal of clinical nutrition 2006-02, Vol.83 (2), p.317-323 |
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| creator | O'Brien, Kimberly O Donangelo, Carmen M Zapata, Carmina L Vargas Abrams, Steven A Spencer, E Martin King, Janet C |
| description | BACKGROUND: Few data exist on longitudinal changes in bone calcium turnover rates across pregnancy and lactation. OBJECTIVE: Our aim was to characterize calcium kinetic variables and predictors of these changes across pregnancy and early lactation in women with low calcium intakes. DESIGN: Stable calcium isotopes were administered to 10 Brazilian women during early pregnancy (EP; weeks 10-12 of gestation), late pregnancy (LP; weeks 34-36 of gestation), and early lactation (EL; 7-8 wk postpartum). Multicompartmental modeling was used to assess the rates of bone calcium turnover in relation to calcium intakes and circulating concentrations of parathyroid hormone (PTH), insulin-like growth factor 1, and 1,25-dihydroxyvitamin D. RESULTS: Rates of bone calcium deposition increased significantly from EP to LP (P = 0.001) and were significantly associated with serum PTH during LP (P |
| doi_str_mv | 10.1093/ajcn/83.2.317 |
| format | Article |
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OBJECTIVE: Our aim was to characterize calcium kinetic variables and predictors of these changes across pregnancy and early lactation in women with low calcium intakes. DESIGN: Stable calcium isotopes were administered to 10 Brazilian women during early pregnancy (EP; weeks 10-12 of gestation), late pregnancy (LP; weeks 34-36 of gestation), and early lactation (EL; 7-8 wk postpartum). Multicompartmental modeling was used to assess the rates of bone calcium turnover in relation to calcium intakes and circulating concentrations of parathyroid hormone (PTH), insulin-like growth factor 1, and 1,25-dihydroxyvitamin D. RESULTS: Rates of bone calcium deposition increased significantly from EP to LP (P = 0.001) and were significantly associated with serum PTH during LP (P </= 0.01). Rates of bone calcium resorption were also higher during LP and EL than during EP (P </= 0.01) and were associated with both PTH (P </= 0.01) and IGF-1 (P </= 0.05) during LP but not during EL. Net balance in bone calcium turnover was positively associated with dietary calcium during EP (P </= 0.01), LP (P </= 0.01), and EL (P </= 0.01). The mean (±SD) calcium intake was 463 ± 182 mg/d and, in combination with insulin-like growth factor 1, explained 68-94% of the variability in net bone calcium balance during pregnancy and lactation. CONCLUSIONS: Net deficits in bone calcium balance occurred during pregnancy and lactation. Increased dietary calcium intake was associated with improved calcium balance; therefore, greater calcium intakes may minimize bone loss across pregnancy and lactation in women with habitual intakes of <500 mg calcium/d.]]></description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/83.2.317</identifier><identifier>PMID: 16469990</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adult ; Biological and medical sciences ; Bone and Bones - metabolism ; bone density ; bone loss ; bone mineralization ; Bone Resorption ; bone turnover ; Bones ; Breastfeeding & lactation ; Calcium ; Calcium - blood ; Calcium - pharmacokinetics ; Calcium - urine ; Calcium Isotopes - urine ; Calcium, Dietary - administration & dosage ; Calcium, Dietary - metabolism ; Diet ; dietary minerals ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; insulin-like growth factor I ; Insulin-Like Growth Factor I - metabolism ; lactating women ; Lactation - metabolism ; maternal nutrition ; mineral metabolism ; nutrient balance ; nutrient deficiencies ; nutrient intake ; Parathyroid Hormone - blood ; Postpartum Period - metabolism ; Pregnancy ; Pregnancy - metabolism ; Pregnancy Trimester, First - metabolism ; Pregnancy Trimester, Third - metabolism ; pregnant women ; stable isotopes ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Women</subject><ispartof>The American journal of clinical nutrition, 2006-02, Vol.83 (2), p.317-323</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Feb 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-616a971a899aac1af5a1bb055fa90d5ff3817a5a18f70968709a4220169097db3</citedby><cites>FETCH-LOGICAL-c467t-616a971a899aac1af5a1bb055fa90d5ff3817a5a18f70968709a4220169097db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17492000$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16469990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Brien, Kimberly O</creatorcontrib><creatorcontrib>Donangelo, Carmen M</creatorcontrib><creatorcontrib>Zapata, Carmina L Vargas</creatorcontrib><creatorcontrib>Abrams, Steven A</creatorcontrib><creatorcontrib>Spencer, E Martin</creatorcontrib><creatorcontrib>King, Janet C</creatorcontrib><title>Bone calcium turnover during pregnancy and lactation in women with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description><![CDATA[BACKGROUND: Few data exist on longitudinal changes in bone calcium turnover rates across pregnancy and lactation. OBJECTIVE: Our aim was to characterize calcium kinetic variables and predictors of these changes across pregnancy and early lactation in women with low calcium intakes. DESIGN: Stable calcium isotopes were administered to 10 Brazilian women during early pregnancy (EP; weeks 10-12 of gestation), late pregnancy (LP; weeks 34-36 of gestation), and early lactation (EL; 7-8 wk postpartum). Multicompartmental modeling was used to assess the rates of bone calcium turnover in relation to calcium intakes and circulating concentrations of parathyroid hormone (PTH), insulin-like growth factor 1, and 1,25-dihydroxyvitamin D. RESULTS: Rates of bone calcium deposition increased significantly from EP to LP (P = 0.001) and were significantly associated with serum PTH during LP (P </= 0.01). Rates of bone calcium resorption were also higher during LP and EL than during EP (P </= 0.01) and were associated with both PTH (P </= 0.01) and IGF-1 (P </= 0.05) during LP but not during EL. Net balance in bone calcium turnover was positively associated with dietary calcium during EP (P </= 0.01), LP (P </= 0.01), and EL (P </= 0.01). The mean (±SD) calcium intake was 463 ± 182 mg/d and, in combination with insulin-like growth factor 1, explained 68-94% of the variability in net bone calcium balance during pregnancy and lactation. CONCLUSIONS: Net deficits in bone calcium balance occurred during pregnancy and lactation. Increased dietary calcium intake was associated with improved calcium balance; therefore, greater calcium intakes may minimize bone loss across pregnancy and lactation in women with habitual intakes of <500 mg calcium/d.]]></description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - metabolism</subject><subject>bone density</subject><subject>bone loss</subject><subject>bone mineralization</subject><subject>Bone Resorption</subject><subject>bone turnover</subject><subject>Bones</subject><subject>Breastfeeding & lactation</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Calcium - pharmacokinetics</subject><subject>Calcium - urine</subject><subject>Calcium Isotopes - urine</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Calcium, Dietary - metabolism</subject><subject>Diet</subject><subject>dietary minerals</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>lactating women</subject><subject>Lactation - metabolism</subject><subject>maternal nutrition</subject><subject>mineral metabolism</subject><subject>nutrient balance</subject><subject>nutrient deficiencies</subject><subject>nutrient intake</subject><subject>Parathyroid Hormone - blood</subject><subject>Postpartum Period - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy - metabolism</subject><subject>Pregnancy Trimester, First - metabolism</subject><subject>Pregnancy Trimester, Third - metabolism</subject><subject>pregnant women</subject><subject>stable isotopes</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkk-PFCEQxYnRuOPq0asSE731LDTdDRx1479kEw-6Z1JDw8jYDSPQTvZr-Qmt3RndxEuRwI_3inoQ8pyzNWdaXMDOxgsl1u1acPmArLgWqhEtkw_JijHWNpoP_Rl5UsqOMd52anhMzvjQDVprtiK_36XoqIXJhmWmdckx_XKZjksOcUv32W0jRHtDIY50AluhhhRpiPSQZoc11O90Sod_CmNwtdBQKJSSbIDqxiP0Fwixwg93p2dDtsuEiugUYlmmEJsp4OE2pwNe8eiXMuXUpmhdrPnOvDwljzxMxT07refk-sP7b5efmqsvHz9fvr1qbDfI2gx8AC05KK0BLAffA99sWN970GzsvReKS8BN5SXTg8ICXdsyPmim5bgR5-TNUXef08_FlWrmUKybJoguLcVwyYViUiP46j9wl3CQ2JtpBde9wFYQao6QzamU7LzZ5zBDvjGcmdskzW2SRgnTGkwS-Rcn0WUzu_GePkWHwOsTAAWH6zPmFMo9Jzvd4gdA7uWR85AMbDMy11_xmYJx1gultPgDaQeziw</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>O'Brien, Kimberly O</creator><creator>Donangelo, Carmen M</creator><creator>Zapata, Carmina L Vargas</creator><creator>Abrams, Steven A</creator><creator>Spencer, E Martin</creator><creator>King, Janet C</creator><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20060201</creationdate><title>Bone calcium turnover during pregnancy and lactation in women with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations</title><author>O'Brien, Kimberly O ; Donangelo, Carmen M ; Zapata, Carmina L Vargas ; Abrams, Steven A ; Spencer, E Martin ; King, Janet C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-616a971a899aac1af5a1bb055fa90d5ff3817a5a18f70968709a4220169097db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - metabolism</topic><topic>bone density</topic><topic>bone loss</topic><topic>bone mineralization</topic><topic>Bone Resorption</topic><topic>bone turnover</topic><topic>Bones</topic><topic>Breastfeeding & lactation</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Calcium - pharmacokinetics</topic><topic>Calcium - urine</topic><topic>Calcium Isotopes - urine</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Calcium, Dietary - metabolism</topic><topic>Diet</topic><topic>dietary minerals</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>lactating women</topic><topic>Lactation - metabolism</topic><topic>maternal nutrition</topic><topic>mineral metabolism</topic><topic>nutrient balance</topic><topic>nutrient deficiencies</topic><topic>nutrient intake</topic><topic>Parathyroid Hormone - blood</topic><topic>Postpartum Period - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy - metabolism</topic><topic>Pregnancy Trimester, First - metabolism</topic><topic>Pregnancy Trimester, Third - metabolism</topic><topic>pregnant women</topic><topic>stable isotopes</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Brien, Kimberly O</creatorcontrib><creatorcontrib>Donangelo, Carmen M</creatorcontrib><creatorcontrib>Zapata, Carmina L Vargas</creatorcontrib><creatorcontrib>Abrams, Steven A</creatorcontrib><creatorcontrib>Spencer, E Martin</creatorcontrib><creatorcontrib>King, Janet C</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Brien, Kimberly O</au><au>Donangelo, Carmen M</au><au>Zapata, Carmina L Vargas</au><au>Abrams, Steven A</au><au>Spencer, E Martin</au><au>King, Janet C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone calcium turnover during pregnancy and lactation in women with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>83</volume><issue>2</issue><spage>317</spage><epage>323</epage><pages>317-323</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract><![CDATA[BACKGROUND: Few data exist on longitudinal changes in bone calcium turnover rates across pregnancy and lactation. OBJECTIVE: Our aim was to characterize calcium kinetic variables and predictors of these changes across pregnancy and early lactation in women with low calcium intakes. DESIGN: Stable calcium isotopes were administered to 10 Brazilian women during early pregnancy (EP; weeks 10-12 of gestation), late pregnancy (LP; weeks 34-36 of gestation), and early lactation (EL; 7-8 wk postpartum). Multicompartmental modeling was used to assess the rates of bone calcium turnover in relation to calcium intakes and circulating concentrations of parathyroid hormone (PTH), insulin-like growth factor 1, and 1,25-dihydroxyvitamin D. RESULTS: Rates of bone calcium deposition increased significantly from EP to LP (P = 0.001) and were significantly associated with serum PTH during LP (P </= 0.01). Rates of bone calcium resorption were also higher during LP and EL than during EP (P </= 0.01) and were associated with both PTH (P </= 0.01) and IGF-1 (P </= 0.05) during LP but not during EL. Net balance in bone calcium turnover was positively associated with dietary calcium during EP (P </= 0.01), LP (P </= 0.01), and EL (P </= 0.01). The mean (±SD) calcium intake was 463 ± 182 mg/d and, in combination with insulin-like growth factor 1, explained 68-94% of the variability in net bone calcium balance during pregnancy and lactation. CONCLUSIONS: Net deficits in bone calcium balance occurred during pregnancy and lactation. Increased dietary calcium intake was associated with improved calcium balance; therefore, greater calcium intakes may minimize bone loss across pregnancy and lactation in women with habitual intakes of <500 mg calcium/d.]]></abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>16469990</pmid><doi>10.1093/ajcn/83.2.317</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Bone and Bones - metabolism bone density bone loss bone mineralization Bone Resorption bone turnover Bones Breastfeeding & lactation Calcium Calcium - blood Calcium - pharmacokinetics Calcium - urine Calcium Isotopes - urine Calcium, Dietary - administration & dosage Calcium, Dietary - metabolism Diet dietary minerals Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans insulin-like growth factor I Insulin-Like Growth Factor I - metabolism lactating women Lactation - metabolism maternal nutrition mineral metabolism nutrient balance nutrient deficiencies nutrient intake Parathyroid Hormone - blood Postpartum Period - metabolism Pregnancy Pregnancy - metabolism Pregnancy Trimester, First - metabolism Pregnancy Trimester, Third - metabolism pregnant women stable isotopes Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D - analogs & derivatives Vitamin D - blood Women |
| title | Bone calcium turnover during pregnancy and lactation in women with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations |
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