A Theory for Controlling Cell Cycle Dynamics using a Reversibly Binding Inhibitor

We demonstrate, by using mathematical modeling of cell division cycle (CDC) dynamics, a potential mechanism for precisely controlling the frequency of cell division and regulating the size of a dividing cell. Control of the cell cycle is achieved by artificially expressing a protein that reversibly...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-11, Vol.95 (24), p.14190-14195
Hauptverfasser:	Gardner, Timothy S., Dolnik, Milos, Collins, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell cycle Cell Cycle - drug effects Cell Cycle - physiology Cell cycle proteins Cell Cycle Proteins - physiology Cell division Cell Division - physiology Cells Cellular biology Cyclins Cyclins - physiology Kinetics Mathematical models Mathematics Modeling Models, Biological Oscillation Oscillators Parametric models Phase shift Theory
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