'Naive' and 'memory' CD4 super(+) T-cells and TCR V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion

'Naive' and 'memory' CD4 super(+) T-cells and TCR V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion

The progression of 'naive' and 'memory' T-cells and the T-cell receptor V beta (TCR V beta ) repertoire dynamics within the peripheral CD4 super(+) T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR V beta repertoire perturbations were obser...

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Veröffentlicht in:Immunology letters 1999-03, Vol.66 (3), p.199-206
Hauptverfasser: King, DJS, Amjadi, P, Tilling, R, Kinloch-de-Loes, S
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Human immunodeficiency virus 1
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container_title Immunology letters
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creator King, DJS
Amjadi, P
Tilling, R
Kinloch-de-Loes, S
description The progression of 'naive' and 'memory' T-cells and the T-cell receptor V beta (TCR V beta ) repertoire dynamics within the peripheral CD4 super(+) T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR V beta repertoire perturbations were observed within the CD4 super(+) T-cell pool in treatment-naive patients regardless of their levels of viremia during the first 6-8 months after seroconversion. The ratio of 'naive' to 'memory' CD4 super(+) T-cells as well as the TCR V beta repertoire dynamics did not appear to correlate with absolute numbers of CD4 super(+) T-cells.
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language eng
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source Elsevier ScienceDirect Journals Complete - AutoHoldings
subjects Human immunodeficiency virus 1
title 'Naive' and 'memory' CD4 super(+) T-cells and TCR V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion
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