A Low-Molecular-Weight Inhibitor against the Chemokine Receptor CXCR4: A Strong Anti-HIV Peptide T140

T22 ([Tyr5,12, Lys7]-polyphemusin II) is an 18-residue peptide amide, which has strong anti-HIV activity. T22 inhibits the T cell line-tropic (T-tropic) HIV-1 infection through its specific binding to a chemokine receptor CXCR4, which serves as a coreceptor for the entry of T-tropic HIV-1 strains. H...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-12, Vol.253 (3), p.877-882
Hauptverfasser:	Tamamura, Hirokazu, Xu, Younong, Hattori, Toshio, Zhang, Xiaoyan, Arakaki, Rieko, Kanbara, Kenji, Omagari, Akane, Otaka, Akira, Ibuka, Toshiro, Yamamoto, Naoki, Nakashima, Hideki, Fujii, Nobutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-HIV Agents - pharmacology Anti-HIV Agents - toxicity Antimicrobial Cationic Peptides Cells, Cultured Chemokine CXCL12 Chemokines, CXC - pharmacology Circular Dichroism DNA-Binding Proteins - chemistry Heterocyclic Compounds - pharmacology HIV-1 - drug effects Human immunodeficiency virus 1 Molecular Sequence Data Oligopeptides - chemistry Oligopeptides - pharmacology Oligopeptides - toxicity Peptides - chemistry Peptides - pharmacology Peptides, Cyclic - chemistry Receptors, CXCR4 - antagonists & inhibitors T-Lymphocytes - virology
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