Alterations in the NF2/LATS1/LATS2/YAP Pathway in Schwannomas

Schwannomas are benign nerve sheath tumors composed of well-differentiated Schwann cells. Other than frequent NF2 (neurofibromatosis type 2) mutations (50%–60%), their molecular pathogenesis is not fully understood. LATS1 and LATS2 are downstream molecules of NF2 and are negative regulators of the y...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2015-10, Vol.74 (10), p.952-959
Hauptverfasser:	Oh, Ji-Eun, Ohta, Takashi, Satomi, Kaishi, Foll, Matthieu, Durand, Geoffroy, McKay, James, Calvez-Kelm, Florence Le, Mittelbronn, Michel, Brokinkel, Benjamin, Paulus, Werner, Ohgaki, Hiroko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - physiology Adult Aged DNA Mutational Analysis Female Genes, Neurofibromatosis 2 - physiology Hippo Signaling Pathway Humans Immunohistochemistry Male Middle Aged Neurilemmoma - genetics Neurilemmoma - metabolism Phosphoproteins - physiology Polymerase Chain Reaction Protein Serine-Threonine Kinases - physiology Signal Transduction - physiology Transcription Factors Tumor Suppressor Proteins - physiology YAP-Signaling Proteins
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