Silica-Induced Pulmonary Inflammation in Rats: Activation of NF-κB and Its Suppression by Dexamethasone

The goal of this study was to examine the relationship of the transcriptional regulatory factor nuclear factor-kappaB (NF-κB) to the early inflammatory events involved with silica exposure. Male F-344 rats received an intratracheal (i.t.) instillation of silica (100 mg/kg in a volume of 1 ml/kg) of...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-12, Vol.253 (1), p.181-184
Hauptverfasser:	Sacks, Meir, Gordon, John, Bylander, John, Porter, Dale, Shi, X.L., Castranova, Vincent, Kaczmarczyk, Walter, Van Dyke, Knox, Reasor, Mark J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Bronchoalveolar Lavage Fluid - cytology Cell Count - drug effects Cell Differentiation - drug effects Dexamethasone - administration & dosage Dexamethasone - pharmacology Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Injections, Intraperitoneal Intubation, Intratracheal Luminescent Measurements Luminol - metabolism Lung - drug effects Lung - metabolism Lung - pathology Male NF-kappa B - antagonists & inhibitors NF-kappa B - biosynthesis NF-kappa B - metabolism Rats Rats, Inbred F344 Silicon Dioxide - toxicity
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