Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS
In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive...
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| Veröffentlicht in: | Brain research 1999-01, Vol.815 (1), p.36-43 |
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| creator | Hauss-Wegrzyniak, Beatrice Willard, Lauren B Del Soldato, Piero Pepeu, Giancarlo Wenk, Gary L |
| description | In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was particularly evident in the hippocampus, subiculum and entorhinal and piriform cortices. Daily peripheral administration of NFP dose-dependently, and significantly, attenuated the brain inflammation as indicated by the decreased density and reactive state of microglial cells. Daily peripheral administration of nitro-aspirin also attenuated the brain inflammation, but to a much lesser degree than NFP. The results demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) could reduce brain inflammation and that NFP is an effective anti-inflammatory agent. |
| doi_str_mv | 10.1016/S0006-8993(98)01081-6 |
| format | Article |
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The chronic LPS infusion produced an extensive inflammation that was particularly evident in the hippocampus, subiculum and entorhinal and piriform cortices. Daily peripheral administration of NFP dose-dependently, and significantly, attenuated the brain inflammation as indicated by the decreased density and reactive state of microglial cells. Daily peripheral administration of nitro-aspirin also attenuated the brain inflammation, but to a much lesser degree than NFP. The results demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) could reduce brain inflammation and that NFP is an effective anti-inflammatory agent.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(98)01081-6</identifier><identifier>PMID: 9974120</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Alzheimer's disease ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antibodies, Monoclonal - pharmacology ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Brain inflammation ; Chronic Disease ; Dentate Gyrus - cytology ; Dentate Gyrus - immunology ; Encephalitis - chemically induced ; Encephalitis - drug therapy ; Encephalitis - immunology ; Entorhinal Cortex - cytology ; Entorhinal Cortex - immunology ; Immunohistochemistry ; Lipopolysaccharide ; Lipopolysaccharides ; Male ; Medical sciences ; Microglia ; Microglia - immunology ; Nonsteroidal anti-inflammatory drug (NSAID) ; Pharmacology. 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The chronic LPS infusion produced an extensive inflammation that was particularly evident in the hippocampus, subiculum and entorhinal and piriform cortices. Daily peripheral administration of NFP dose-dependently, and significantly, attenuated the brain inflammation as indicated by the decreased density and reactive state of microglial cells. Daily peripheral administration of nitro-aspirin also attenuated the brain inflammation, but to a much lesser degree than NFP. The results demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) could reduce brain inflammation and that NFP is an effective anti-inflammatory agent.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Brain inflammation</subject><subject>Chronic Disease</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - immunology</subject><subject>Encephalitis - chemically induced</subject><subject>Encephalitis - drug therapy</subject><subject>Encephalitis - immunology</subject><subject>Entorhinal Cortex - cytology</subject><subject>Entorhinal Cortex - immunology</subject><subject>Immunohistochemistry</subject><subject>Lipopolysaccharide</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microglia</subject><subject>Microglia - immunology</subject><subject>Nonsteroidal anti-inflammatory drug (NSAID)</subject><subject>Pharmacology. Drug treatments</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtrFDEUx0Ox1HXbj1CYBxH7MJrLbCZ5krJYFYoWqs8he-aEjcwka5Jt6bc3e2F99OmQ87-c8CPkmtEPjDL58ZFSKlultXiv1Q1lVLFWnpEZUz1vJe_oKzI7WV6TNzn_rk8hNL0gF1r3HeN0Rp4fMPnNGpMdGztMPvhcki0-hia6JsQnrPtQfOuDG-002RKTx9yADY0tBcPWFmzKGht0DqHkXQzWKQYPzSmzq3v2Ze3D3rr8_nhJzp0dM14d55z8uvv8c_m1vf_x5dvy9r6FTsnSggPg1i0oABWaI_ZOSRyk5FVgYiUEMjso1WHPAQRKsGrR8w5op1aKcjEn7w69mxT_bDEXM_kMOI42YNxmw3omeF-5zMniYIQUc07ozCb5yaYXw6jZATd74GZH02hl9sCNrLnr44HtasLhlDoSrvrbo24z2NElG8Dnf-VSSMp1tX062LDCePKYTAaPAXDwqWI1Q_T_-chf5D6fZQ</recordid><startdate>19990102</startdate><enddate>19990102</enddate><creator>Hauss-Wegrzyniak, Beatrice</creator><creator>Willard, Lauren B</creator><creator>Del Soldato, Piero</creator><creator>Pepeu, Giancarlo</creator><creator>Wenk, Gary L</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19990102</creationdate><title>Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS</title><author>Hauss-Wegrzyniak, Beatrice ; Willard, Lauren B ; Del Soldato, Piero ; Pepeu, Giancarlo ; Wenk, Gary L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-cfcc2af50cc0392ee7f86ed662fcc13b33e1ad884e72cc3e6ca85724c048b8023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Brain inflammation</topic><topic>Chronic Disease</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - immunology</topic><topic>Encephalitis - chemically induced</topic><topic>Encephalitis - drug therapy</topic><topic>Encephalitis - immunology</topic><topic>Entorhinal Cortex - cytology</topic><topic>Entorhinal Cortex - immunology</topic><topic>Immunohistochemistry</topic><topic>Lipopolysaccharide</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microglia</topic><topic>Microglia - immunology</topic><topic>Nonsteroidal anti-inflammatory drug (NSAID)</topic><topic>Pharmacology. Drug treatments</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hauss-Wegrzyniak, Beatrice</creatorcontrib><creatorcontrib>Willard, Lauren B</creatorcontrib><creatorcontrib>Del Soldato, Piero</creatorcontrib><creatorcontrib>Pepeu, Giancarlo</creatorcontrib><creatorcontrib>Wenk, Gary L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hauss-Wegrzyniak, Beatrice</au><au>Willard, Lauren B</au><au>Del Soldato, Piero</au><au>Pepeu, Giancarlo</au><au>Wenk, Gary L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1999-01-02</date><risdate>1999</risdate><volume>815</volume><issue>1</issue><spage>36</spage><epage>43</epage><pages>36-43</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was particularly evident in the hippocampus, subiculum and entorhinal and piriform cortices. Daily peripheral administration of NFP dose-dependently, and significantly, attenuated the brain inflammation as indicated by the decreased density and reactive state of microglial cells. Daily peripheral administration of nitro-aspirin also attenuated the brain inflammation, but to a much lesser degree than NFP. The results demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) could reduce brain inflammation and that NFP is an effective anti-inflammatory agent.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>9974120</pmid><doi>10.1016/S0006-8993(98)01081-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Alzheimer's disease Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibodies, Monoclonal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Brain inflammation Chronic Disease Dentate Gyrus - cytology Dentate Gyrus - immunology Encephalitis - chemically induced Encephalitis - drug therapy Encephalitis - immunology Entorhinal Cortex - cytology Entorhinal Cortex - immunology Immunohistochemistry Lipopolysaccharide Lipopolysaccharides Male Medical sciences Microglia Microglia - immunology Nonsteroidal anti-inflammatory drug (NSAID) Pharmacology. Drug treatments Rat Rats Rats, Inbred F344 |
| title | Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS |
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