Transmission of Integrated Human Herpesvirus 6 through Stem Cell Transplantation: Implications for Laboratory Diagnosis
We identified a stem cell donor with chromosomally integrated human herpesvirus (HHV)–6 and monitored the recipient for HHV-6 after transplantation. The appearance and subsequent increase in HHV-6 load paralleled engraftment and an increase in white blood cell count. Fluorescent in situ hybridizatio...
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| Veröffentlicht in: | The Journal of infectious diseases 2006-04, Vol.193 (7), p.912-916 |
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| container_title | The Journal of infectious diseases |
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| creator | Clark, Duncan A. Nacheva, Elisabeth P. Leong, Hoe Nam Brazma, Diana Li, Ying Ting Tsao, Edward H. F. Buyck, Hubertus C. E. Atkinson, Claire E. Lawson, Heather M. Potter, Michael N. Griffiths, Paul D. |
| description | We identified a stem cell donor with chromosomally integrated human herpesvirus (HHV)–6 and monitored the recipient for HHV-6 after transplantation. The appearance and subsequent increase in HHV-6 load paralleled engraftment and an increase in white blood cell count. Fluorescent in situ hybridization analysis showed integrated HHV-6 on chromosome band 17p13.3 in the donor and in the recipient after transplantation but not in the recipient before transplantation. The increase in viral load due to the genetic transmission of integrated HHV-6 could have been misinterpreted as substantial active infection and, thus, led to the administration of toxic antiviral therapy. We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV-6 with disease |
| doi_str_mv | 10.1086/500838 |
| format | Article |
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The increase in viral load due to the genetic transmission of integrated HHV-6 could have been misinterpreted as substantial active infection and, thus, led to the administration of toxic antiviral therapy. We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV-6 with disease</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/500838</identifier><identifier>PMID: 16518751</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Biological and medical sciences ; Blood ; Chromosomes ; Chromosomes, Human - virology ; DNA, Viral - analysis ; DNA, Viral - genetics ; Female ; Fundamental and applied biological sciences. 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Psychology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Herpesviridae</topic><topic>Herpesvirus 6, Human - genetics</topic><topic>Herpesvirus 6, Human - isolation & purification</topic><topic>Human herpesvirus 6</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Polymerase chain reaction</topic><topic>Proviruses - genetics</topic><topic>Roseolovirus Infections - transmission</topic><topic>Roseolovirus Infections - virology</topic><topic>Stem cells</topic><topic>Transplantation</topic><topic>Viral Load</topic><topic>Virus Integration</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clark, Duncan A.</creatorcontrib><creatorcontrib>Nacheva, Elisabeth P.</creatorcontrib><creatorcontrib>Leong, Hoe Nam</creatorcontrib><creatorcontrib>Brazma, Diana</creatorcontrib><creatorcontrib>Li, Ying Ting</creatorcontrib><creatorcontrib>Tsao, Edward H. 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Fluorescent in situ hybridization analysis showed integrated HHV-6 on chromosome band 17p13.3 in the donor and in the recipient after transplantation but not in the recipient before transplantation. The increase in viral load due to the genetic transmission of integrated HHV-6 could have been misinterpreted as substantial active infection and, thus, led to the administration of toxic antiviral therapy. We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV-6 with disease</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16518751</pmid><doi>10.1086/500838</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 2006-04, Vol.193 (7), p.912-916 |
| issn | 0022-1899 1537-6613 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Blood Chromosomes Chromosomes, Human - virology DNA, Viral - analysis DNA, Viral - genetics Female Fundamental and applied biological sciences. Psychology Hematopoietic Stem Cell Transplantation Herpesviridae Herpesvirus 6, Human - genetics Herpesvirus 6, Human - isolation & purification Human herpesvirus 6 Humans In Situ Hybridization, Fluorescence Infections Infectious diseases Leukemia, Myeloid, Acute - therapy Male Medical sciences Microbiology Middle Aged Polymerase chain reaction Proviruses - genetics Roseolovirus Infections - transmission Roseolovirus Infections - virology Stem cells Transplantation Viral Load Virus Integration Viruses |
| title | Transmission of Integrated Human Herpesvirus 6 through Stem Cell Transplantation: Implications for Laboratory Diagnosis |
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