Mortality and Morbidity of Workers Exposed to Acrylonitrile in Fiber Production
This study assessed the risk of cancer mortality and incidence among 2559 employees exposed to acrylonitrile in the production of Orion® at 2 plants in 1944—1991. Latency, duration of exposure, highest level of exposure ever experienced, and cumulative exposure were used as indicators of exposure. T...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1998-01, Vol.24 (2), p.54-62 |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
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| creator | Wood, Susan M Buffler, Patricia A Burau, Keith Krivanek, Neil |
| description | This study assessed the risk of cancer mortality and incidence among 2559 employees exposed to acrylonitrile in the production of Orion® at 2 plants in 1944—1991. Latency, duration of exposure, highest level of exposure ever experienced, and cumulative exposure were used as indicators of exposure. The average duration of exposure for the workers was 7.6 years with an average cumulative exposure of 57.6 ppm-years. Overall mortality was lower than expected in a comparison with the United States population and all DuPont employees [454 deaths, standardized mortality ratios (SMR) of 69 and 91, respectively)]. All the cancer death ratios were lower than expected in a similar comparison. The SMR values for specific sites did not differ significantly from the expected values. Mortality from all cancers and from prostate, respiratory, and digestive cancer did not show any significantly associated increases or a consistent pattern suggestive of a dose-response. The cancer morbidity patterns were similarly unremarkable. |
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Latency, duration of exposure, highest level of exposure ever experienced, and cumulative exposure were used as indicators of exposure. The average duration of exposure for the workers was 7.6 years with an average cumulative exposure of 57.6 ppm-years. Overall mortality was lower than expected in a comparison with the United States population and all DuPont employees [454 deaths, standardized mortality ratios (SMR) of 69 and 91, respectively)]. All the cancer death ratios were lower than expected in a similar comparison. The SMR values for specific sites did not differ significantly from the expected values. Mortality from all cancers and from prostate, respiratory, and digestive cancer did not show any significantly associated increases or a consistent pattern suggestive of a dose-response. The cancer morbidity patterns were similarly unremarkable.</description><identifier>ISSN: 0355-3140</identifier><identifier>EISSN: 1795-990X</identifier><identifier>PMID: 9714513</identifier><language>eng</language><publisher>Finland: Scandinavian Journal of Work, Environment ＆ Health</publisher><subject>Acrylic Resins - adverse effects ; Acrylonitrile - adverse effects ; Adult ; Aged ; Cancer ; Cancer incidence ; Cause of Death ; Central nervous system ; Chemical Industry - statistics & numerical data ; Cohort Studies ; Confidence Intervals ; Death ; Employees ; Environmental Monitoring ; Epidemiological Monitoring ; Female ; Fiber crops ; Humans ; Incidence ; Male ; Middle Aged ; Morbidity ; Mortality ; Neoplasms - chemically induced ; Neoplasms - epidemiology ; Neoplasms - mortality ; Occupational Exposure - adverse effects ; Occupational Exposure - statistics & numerical data ; Prostate ; Prostate cancer ; Risk Factors ; Time Factors ; United States - epidemiology</subject><ispartof>Scandinavian Journal of Work, Environment ＆ Health, 1998-01, Vol.24 (2), p.54-62</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40966825$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40966825$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9714513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, Susan M</creatorcontrib><creatorcontrib>Buffler, Patricia A</creatorcontrib><creatorcontrib>Burau, Keith</creatorcontrib><creatorcontrib>Krivanek, Neil</creatorcontrib><title>Mortality and Morbidity of Workers Exposed to Acrylonitrile in Fiber Production</title><title>Scandinavian Journal of Work, Environment ＆ Health</title><addtitle>Scand J Work Environ Health</addtitle><description>This study assessed the risk of cancer mortality and incidence among 2559 employees exposed to acrylonitrile in the production of Orion® at 2 plants in 1944—1991. Latency, duration of exposure, highest level of exposure ever experienced, and cumulative exposure were used as indicators of exposure. The average duration of exposure for the workers was 7.6 years with an average cumulative exposure of 57.6 ppm-years. Overall mortality was lower than expected in a comparison with the United States population and all DuPont employees [454 deaths, standardized mortality ratios (SMR) of 69 and 91, respectively)]. All the cancer death ratios were lower than expected in a similar comparison. The SMR values for specific sites did not differ significantly from the expected values. Mortality from all cancers and from prostate, respiratory, and digestive cancer did not show any significantly associated increases or a consistent pattern suggestive of a dose-response. The cancer morbidity patterns were similarly unremarkable.</description><subject>Acrylic Resins - adverse effects</subject><subject>Acrylonitrile - adverse effects</subject><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Cancer incidence</subject><subject>Cause of Death</subject><subject>Central nervous system</subject><subject>Chemical Industry - statistics & numerical data</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Death</subject><subject>Employees</subject><subject>Environmental Monitoring</subject><subject>Epidemiological Monitoring</subject><subject>Female</subject><subject>Fiber crops</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neoplasms - chemically induced</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - mortality</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - statistics & numerical data</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9LAzEQxYMotVY_gpCTt4XMbv4ei1gVKvWg6C1sNllI3W5qkgX77d3SonjyNDx-j2HmvRM0BaFYoRR5P0VTUjFWVEDJObpIaU1IqVgpJmiiBFAG1RStnkLMdefzDte9xaMy3u5VaPFbiB8uJnz3tQ3JWZwDnjdx14Xe5-g7h32PF964iJ9jsEOTfegv0Vlbd8ldHecMvS7uXm4fiuXq_vF2vizqSrFcMGYIaYBKqCxVlsu2AaZkq4BXtHSWMmucEIIaKTizrXGMj9db04wf8LapZujmsHcbw-fgUtYbnxrXdXXvwpA0CCglCPq_kVIpKcBovD4aB7NxVm-j39Rxp49R_fJ1yiH-YEoU57JkI18ceO2jz16vwxD7MQK9L2HfgQalJJS6JEAAgBAC7K9gVPOy-gaF6oI5</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Wood, Susan M</creator><creator>Buffler, Patricia A</creator><creator>Burau, Keith</creator><creator>Krivanek, Neil</creator><general>Scandinavian Journal of Work, Environment ＆ Health</general><general>National Institute for Working Life</general><general>Finnish Institute of Occupational Health</general><general>National Institute of Occupational Health (Denmark)</general><general>National Institute of Occupational Health (Norway)</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope></search><sort><creationdate>19980101</creationdate><title>Mortality and Morbidity of Workers Exposed to Acrylonitrile in Fiber Production</title><author>Wood, Susan M ; Buffler, Patricia A ; Burau, Keith ; Krivanek, Neil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a395t-55b00c14813d49d68fc1598f916342ed45dbe7774b8765dfbe56002dbc2956fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acrylic Resins - adverse effects</topic><topic>Acrylonitrile - adverse effects</topic><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Cancer incidence</topic><topic>Cause of Death</topic><topic>Central nervous system</topic><topic>Chemical Industry - statistics & numerical data</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Death</topic><topic>Employees</topic><topic>Environmental Monitoring</topic><topic>Epidemiological Monitoring</topic><topic>Female</topic><topic>Fiber crops</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neoplasms - chemically induced</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - mortality</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - statistics & numerical data</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, Susan M</creatorcontrib><creatorcontrib>Buffler, Patricia A</creatorcontrib><creatorcontrib>Burau, Keith</creatorcontrib><creatorcontrib>Krivanek, Neil</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, Susan M</au><au>Buffler, Patricia A</au><au>Burau, Keith</au><au>Krivanek, Neil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality and Morbidity of Workers Exposed to Acrylonitrile in Fiber Production</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>24</volume><issue>2</issue><spage>54</spage><epage>62</epage><pages>54-62</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>This study assessed the risk of cancer mortality and incidence among 2559 employees exposed to acrylonitrile in the production of Orion® at 2 plants in 1944—1991. Latency, duration of exposure, highest level of exposure ever experienced, and cumulative exposure were used as indicators of exposure. The average duration of exposure for the workers was 7.6 years with an average cumulative exposure of 57.6 ppm-years. Overall mortality was lower than expected in a comparison with the United States population and all DuPont employees [454 deaths, standardized mortality ratios (SMR) of 69 and 91, respectively)]. All the cancer death ratios were lower than expected in a similar comparison. The SMR values for specific sites did not differ significantly from the expected values. Mortality from all cancers and from prostate, respiratory, and digestive cancer did not show any significantly associated increases or a consistent pattern suggestive of a dose-response. The cancer morbidity patterns were similarly unremarkable.</abstract><cop>Finland</cop><pub>Scandinavian Journal of Work, Environment ＆ Health</pub><pmid>9714513</pmid><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0355-3140 |
| ispartof | Scandinavian Journal of Work, Environment ＆ Health, 1998-01, Vol.24 (2), p.54-62 |
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| source | Jstor Complete Legacy; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acrylic Resins - adverse effects Acrylonitrile - adverse effects Adult Aged Cancer Cancer incidence Cause of Death Central nervous system Chemical Industry - statistics & numerical data Cohort Studies Confidence Intervals Death Employees Environmental Monitoring Epidemiological Monitoring Female Fiber crops Humans Incidence Male Middle Aged Morbidity Mortality Neoplasms - chemically induced Neoplasms - epidemiology Neoplasms - mortality Occupational Exposure - adverse effects Occupational Exposure - statistics & numerical data Prostate Prostate cancer Risk Factors Time Factors United States - epidemiology |
| title | Mortality and Morbidity of Workers Exposed to Acrylonitrile in Fiber Production |
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