Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression

Purpose Nerve growth factor (NGF) expression and activity is important in chronic lower back pain but may also act as a pro-catabolic factor in the pathogenesis of intervertebral disc (IVD) degeneration. Lipocalin 2 (Lcn2) expression in IVD was upregulated by NGF stimulation in our previous study. T...

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Veröffentlicht in:	European spine journal 2015-09, Vol.24 (9), p.1959-1968
Hauptverfasser:	Kao, Ting-Hsien, Peng, Yi-Jen, Salter, Donald M., Lee, Herng-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Intervertebral Disc - drug effects Intervertebral Disc - metabolism Intervertebral Disc Degeneration Lipocalin-2 Lipocalins - drug effects Lipocalins - metabolism Matrix Metalloproteinase 9 - drug effects Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medicine Medicine & Public Health Nerve Growth Factor - antagonists & inhibitors Nerve Growth Factor - pharmacology Neurosurgery Original Article Pteridines - pharmacology Rats Real-Time Polymerase Chain Reaction Surgical Orthopedics Transcriptional Activation Up-Regulation
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