Single-nucleotide polymorphism of Toll-like receptor 4 and interleukin-10 in response to interferon-based therapy in Egyptian chronic hepatitis C patients

Egypt has the highest prevalence of hepatitis C virus (HCV) in the world. It has been suggested that not only the virus but also the interaction between the virus and the host immune system is important in determining the course of the infection and the response to interferon (IFN)-based therapy. Wh...

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Veröffentlicht in:	Archives of virology 2015-09, Vol.160 (9), p.2181-2195
Hauptverfasser:	Sadik, Nermin Abdel Hamid, Shaker, Olfat Gamil, Ghanem, Hassan Zaki, Hassan, Heba Akram, Abdel-Hamid, Abdel-Hamid Zaki
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity Adult Antiviral Agents - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine blood serum chronic hepatitis C Cytokines Drug Therapy, Combination - methods Egypt Female Gene Frequency genes Genotype Growth factors Health surveys Hepatitis B Hepatitis C Hepatitis C virus Hepatitis C, Chronic - drug therapy Humans Immune system Infections Infectious Diseases innate immunity Interferon Interferon-alpha - therapeutic use interferons Interferons - therapeutic use interleukin-10 Interleukin-10 - genetics Kinases Male Medical Microbiology Middle Aged Original Article patients Polyethylene Glycols - therapeutic use Polymorphism Polymorphism, Single Nucleotide prediction Prospective Studies Recombinant Proteins - therapeutic use Ribavirin - therapeutic use single nucleotide polymorphism therapeutics Toll-like receptor 4 Toll-Like Receptor 4 - genetics Treatment Outcome Tumor necrosis factor-TNF Virology Viruses Young Adult
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