Biochemical and functional characterizations of tyrosine phosphatases from pathogenic and nonpathogenic mycobacteria: indication of phenyl cyclopropyl methyl-/phenyl butenyl azoles as tyrosine phosphatase inhibitors

Tyrosine phosphorylation is one of the most common means of posttranslational modifications which can generate novel recognition motifs for protein interactions and thereafter affecting cellular localization, protein stability, and enzyme activity. Mycobacterium tuberculosis (Mtb) possesses a wide r...

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Veröffentlicht in:	Applied microbiology and biotechnology 2015-09, Vol.99 (18), p.7539-7548
Hauptverfasser:	Chatterjee, Aditi, Pandey, Sapna, Singh, Pramod K, Pathak, Navendu Prakash, Rai, Niyati, Ramachandran, Ravishankar, Tripathi, Rama Pati, Srivastava, Kishore K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antitubercular Agents - metabolism azoles Azoles - metabolism Bacteria Biochemistry Biomedical and Life Sciences Biotechnologically Relevant Enzymes and Proteins Biotechnology Cellular signal transduction Chemical properties Chromatography Cloning Drug development Drug resistance E coli Enzymatic activity enzyme activity Enzyme Inhibitors - metabolism Enzymes functional diversity Kinases Kinetics Life Sciences macrophages Microbial Genetics and Genomics Microbiology Mycobacteria Mycobacterium smegmatis Mycobacterium smegmatis - enzymology Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Phosphatase Phosphatases phosphorylation Physiological aspects post-translational modification Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - metabolism Proteins Research centers Signal transduction Studies Tuberculosis Tyrosine
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