MRI T2 mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model
Purpose To evaluate intervertebral disc (IVD) degeneration and treatments, an objective diagnostic tool is needed. Recently, T2* relaxation time mapping was proposed as a technique to assess early IVD degeneration, yet the correlation with biochemical content and histological features has not been i...
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| Veröffentlicht in: | European spine journal 2015-09, Vol.24 (9), p.1935-1943 |
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| container_issue | 9 |
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| container_title | European spine journal |
| container_volume | 24 |
| creator | Detiger, Suzanne E. L. Holewijn, Roderick M. Hoogendoorn, Roel J. W. van Royen, Barend J. Helder, Marco N. Berger, Ferco H. Kuijer, Joost P. A. Smit, Theo H. |
| description | Purpose
To evaluate intervertebral disc (IVD) degeneration and treatments, an objective diagnostic tool is needed. Recently, T2* relaxation time mapping was proposed as a technique to assess early IVD degeneration, yet the correlation with biochemical content and histological features has not been investigated previously. Our objective was to validate T2* mapping for disc degeneration by correlating this technique with accepted parameters of IVD degeneration.
Methods
Mildly and severely degenerated lumbar discs were obtained from an in vivo large animal study; two healthy goat spines were acquired as control. In total, 48 IVDs were analysed using T2-weighted MRI, T2* relaxation time mapping, biochemical assays, macroscopic and histological scoring. Correlations between variables were expressed with Spearman’s rho (ρ) coefficients.
Results
A complete range of degenerative grades were obtained (mean histological grade 2.2, range 0–6). A linear positive correlation was observed between T2* relaxation time and glycosaminoglycan content (
ρ
= 0.64,
p
|
| doi_str_mv | 10.1007/s00586-014-3498-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1712773175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3788982841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-2b522d5c6d24d467bf2e73a6706506d1d14a05c1c35687fa7dd50cd3a7de57e03</originalsourceid><addsrcrecordid>eNqNkV2L1TAQhoMo7nH1B3gjAW-8qc6k-WgvZfFjYUWQ9TqkyZyeLm1zTFrl_HtTzioiCMLADOR532HyMvYc4TUCmDcZQDW6ApRVLdumwgdsh7IWFbS1eMh20EqotMH2gj3J-Q4AVQv6MbsQCloUGnds_fTlmt8KPrnjcZh77mNKNLqFMv8xLAfeDdEfaBrykk7czYEfyhjH2J_4MJdaKH2ntFCX3MjDkD0P1NNMyS1D3ADu-OhST0U8TIWZYqDxKXu0d2OmZ_f9kn19_-726mN18_nD9dXbm8pLo5ZKdEqIoLwOQgapTbcXZGqnDWgFOmBA6UB59LXSjdk7E4ICH-oykDIE9SV7dfY9pvhtpbzYcomncXQzxTVbNCiMqdGo_0ChQY2ATUFf_oXexTXN5ZCNMrKVSm-78Uz5FHNOtLfHVH4gnSyC3eKz5_hsic9u8Vksmhf3zms3Ufit-JVXAcQZyOVp7in9sfqfrj8BRmik8g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1707494560</pqid></control><display><type>article</type><title>MRI T2 mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Detiger, Suzanne E. L. ; Holewijn, Roderick M. ; Hoogendoorn, Roel J. W. ; van Royen, Barend J. ; Helder, Marco N. ; Berger, Ferco H. ; Kuijer, Joost P. A. ; Smit, Theo H.</creator><creatorcontrib>Detiger, Suzanne E. L. ; Holewijn, Roderick M. ; Hoogendoorn, Roel J. W. ; van Royen, Barend J. ; Helder, Marco N. ; Berger, Ferco H. ; Kuijer, Joost P. A. ; Smit, Theo H.</creatorcontrib><description>Purpose
To evaluate intervertebral disc (IVD) degeneration and treatments, an objective diagnostic tool is needed. Recently, T2* relaxation time mapping was proposed as a technique to assess early IVD degeneration, yet the correlation with biochemical content and histological features has not been investigated previously. Our objective was to validate T2* mapping for disc degeneration by correlating this technique with accepted parameters of IVD degeneration.
Methods
Mildly and severely degenerated lumbar discs were obtained from an in vivo large animal study; two healthy goat spines were acquired as control. In total, 48 IVDs were analysed using T2-weighted MRI, T2* relaxation time mapping, biochemical assays, macroscopic and histological scoring. Correlations between variables were expressed with Spearman’s rho (ρ) coefficients.
Results
A complete range of degenerative grades were obtained (mean histological grade 2.2, range 0–6). A linear positive correlation was observed between T2* relaxation time and glycosaminoglycan content (
ρ
= 0.64,
p
< 0.001). T2* relaxation time decreased linearly with increasing degeneration as assessed with Pfirrmann scoring system (
ρ
= −0.67,
p
< 0.001), macroscopic (
ρ
= −0.33,
p
< 0.05) and histological (
ρ
= −0.45,
p
< 0.05) grading.
Conclusions
T2* mapping is an MRI technique for IVD evaluation which allows for measurements on a continuous scale thus minimising observer bias compared to grading systems. Although limited by a small sample size, this study showed a relatively good and linear correlation between T2* relaxation time and accepted parameters of disc degeneration. This suggests that T2* mapping is a promising tool to assess disc degeneration in clinical practice.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-014-3498-1</identifier><identifier>PMID: 25091261</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Biochemistry ; Disease Models, Animal ; Glycosaminoglycans - analysis ; Goats ; Humans ; Intervertebral Disc Degeneration - diagnosis ; Intervertebral Disc Degeneration - pathology ; Linear Models ; Lumbar Vertebrae - pathology ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine & Public Health ; Neurosurgery ; Observer Variation ; Original Article ; Surgical Orthopedics</subject><ispartof>European spine journal, 2015-09, Vol.24 (9), p.1935-1943</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-2b522d5c6d24d467bf2e73a6706506d1d14a05c1c35687fa7dd50cd3a7de57e03</citedby><cites>FETCH-LOGICAL-c475t-2b522d5c6d24d467bf2e73a6706506d1d14a05c1c35687fa7dd50cd3a7de57e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00586-014-3498-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00586-014-3498-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25091261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Detiger, Suzanne E. L.</creatorcontrib><creatorcontrib>Holewijn, Roderick M.</creatorcontrib><creatorcontrib>Hoogendoorn, Roel J. W.</creatorcontrib><creatorcontrib>van Royen, Barend J.</creatorcontrib><creatorcontrib>Helder, Marco N.</creatorcontrib><creatorcontrib>Berger, Ferco H.</creatorcontrib><creatorcontrib>Kuijer, Joost P. A.</creatorcontrib><creatorcontrib>Smit, Theo H.</creatorcontrib><title>MRI T2 mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Purpose
To evaluate intervertebral disc (IVD) degeneration and treatments, an objective diagnostic tool is needed. Recently, T2* relaxation time mapping was proposed as a technique to assess early IVD degeneration, yet the correlation with biochemical content and histological features has not been investigated previously. Our objective was to validate T2* mapping for disc degeneration by correlating this technique with accepted parameters of IVD degeneration.
Methods
Mildly and severely degenerated lumbar discs were obtained from an in vivo large animal study; two healthy goat spines were acquired as control. In total, 48 IVDs were analysed using T2-weighted MRI, T2* relaxation time mapping, biochemical assays, macroscopic and histological scoring. Correlations between variables were expressed with Spearman’s rho (ρ) coefficients.
Results
A complete range of degenerative grades were obtained (mean histological grade 2.2, range 0–6). A linear positive correlation was observed between T2* relaxation time and glycosaminoglycan content (
ρ
= 0.64,
p
< 0.001). T2* relaxation time decreased linearly with increasing degeneration as assessed with Pfirrmann scoring system (
ρ
= −0.67,
p
< 0.001), macroscopic (
ρ
= −0.33,
p
< 0.05) and histological (
ρ
= −0.45,
p
< 0.05) grading.
Conclusions
T2* mapping is an MRI technique for IVD evaluation which allows for measurements on a continuous scale thus minimising observer bias compared to grading systems. Although limited by a small sample size, this study showed a relatively good and linear correlation between T2* relaxation time and accepted parameters of disc degeneration. This suggests that T2* mapping is a promising tool to assess disc degeneration in clinical practice.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Disease Models, Animal</subject><subject>Glycosaminoglycans - analysis</subject><subject>Goats</subject><subject>Humans</subject><subject>Intervertebral Disc Degeneration - diagnosis</subject><subject>Intervertebral Disc Degeneration - pathology</subject><subject>Linear Models</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Observer Variation</subject><subject>Original Article</subject><subject>Surgical Orthopedics</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkV2L1TAQhoMo7nH1B3gjAW-8qc6k-WgvZfFjYUWQ9TqkyZyeLm1zTFrl_HtTzioiCMLADOR532HyMvYc4TUCmDcZQDW6ApRVLdumwgdsh7IWFbS1eMh20EqotMH2gj3J-Q4AVQv6MbsQCloUGnds_fTlmt8KPrnjcZh77mNKNLqFMv8xLAfeDdEfaBrykk7czYEfyhjH2J_4MJdaKH2ntFCX3MjDkD0P1NNMyS1D3ADu-OhST0U8TIWZYqDxKXu0d2OmZ_f9kn19_-726mN18_nD9dXbm8pLo5ZKdEqIoLwOQgapTbcXZGqnDWgFOmBA6UB59LXSjdk7E4ICH-oykDIE9SV7dfY9pvhtpbzYcomncXQzxTVbNCiMqdGo_0ChQY2ATUFf_oXexTXN5ZCNMrKVSm-78Uz5FHNOtLfHVH4gnSyC3eKz5_hsic9u8Vksmhf3zms3Ufit-JVXAcQZyOVp7in9sfqfrj8BRmik8g</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Detiger, Suzanne E. L.</creator><creator>Holewijn, Roderick M.</creator><creator>Hoogendoorn, Roel J. W.</creator><creator>van Royen, Barend J.</creator><creator>Helder, Marco N.</creator><creator>Berger, Ferco H.</creator><creator>Kuijer, Joost P. A.</creator><creator>Smit, Theo H.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>MRI T2 mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model</title><author>Detiger, Suzanne E. L. ; Holewijn, Roderick M. ; Hoogendoorn, Roel J. W. ; van Royen, Barend J. ; Helder, Marco N. ; Berger, Ferco H. ; Kuijer, Joost P. A. ; Smit, Theo H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-2b522d5c6d24d467bf2e73a6706506d1d14a05c1c35687fa7dd50cd3a7de57e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Disease Models, Animal</topic><topic>Glycosaminoglycans - analysis</topic><topic>Goats</topic><topic>Humans</topic><topic>Intervertebral Disc Degeneration - diagnosis</topic><topic>Intervertebral Disc Degeneration - pathology</topic><topic>Linear Models</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Observer Variation</topic><topic>Original Article</topic><topic>Surgical Orthopedics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Detiger, Suzanne E. L.</creatorcontrib><creatorcontrib>Holewijn, Roderick M.</creatorcontrib><creatorcontrib>Hoogendoorn, Roel J. W.</creatorcontrib><creatorcontrib>van Royen, Barend J.</creatorcontrib><creatorcontrib>Helder, Marco N.</creatorcontrib><creatorcontrib>Berger, Ferco H.</creatorcontrib><creatorcontrib>Kuijer, Joost P. A.</creatorcontrib><creatorcontrib>Smit, Theo H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Detiger, Suzanne E. L.</au><au>Holewijn, Roderick M.</au><au>Hoogendoorn, Roel J. W.</au><au>van Royen, Barend J.</au><au>Helder, Marco N.</au><au>Berger, Ferco H.</au><au>Kuijer, Joost P. A.</au><au>Smit, Theo H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI T2 mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>24</volume><issue>9</issue><spage>1935</spage><epage>1943</epage><pages>1935-1943</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Purpose
To evaluate intervertebral disc (IVD) degeneration and treatments, an objective diagnostic tool is needed. Recently, T2* relaxation time mapping was proposed as a technique to assess early IVD degeneration, yet the correlation with biochemical content and histological features has not been investigated previously. Our objective was to validate T2* mapping for disc degeneration by correlating this technique with accepted parameters of IVD degeneration.
Methods
Mildly and severely degenerated lumbar discs were obtained from an in vivo large animal study; two healthy goat spines were acquired as control. In total, 48 IVDs were analysed using T2-weighted MRI, T2* relaxation time mapping, biochemical assays, macroscopic and histological scoring. Correlations between variables were expressed with Spearman’s rho (ρ) coefficients.
Results
A complete range of degenerative grades were obtained (mean histological grade 2.2, range 0–6). A linear positive correlation was observed between T2* relaxation time and glycosaminoglycan content (
ρ
= 0.64,
p
< 0.001). T2* relaxation time decreased linearly with increasing degeneration as assessed with Pfirrmann scoring system (
ρ
= −0.67,
p
< 0.001), macroscopic (
ρ
= −0.33,
p
< 0.05) and histological (
ρ
= −0.45,
p
< 0.05) grading.
Conclusions
T2* mapping is an MRI technique for IVD evaluation which allows for measurements on a continuous scale thus minimising observer bias compared to grading systems. Although limited by a small sample size, this study showed a relatively good and linear correlation between T2* relaxation time and accepted parameters of disc degeneration. This suggests that T2* mapping is a promising tool to assess disc degeneration in clinical practice.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25091261</pmid><doi>10.1007/s00586-014-3498-1</doi><tpages>9</tpages></addata></record> |
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| ispartof | European spine journal, 2015-09, Vol.24 (9), p.1935-1943 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biochemistry Disease Models, Animal Glycosaminoglycans - analysis Goats Humans Intervertebral Disc Degeneration - diagnosis Intervertebral Disc Degeneration - pathology Linear Models Lumbar Vertebrae - pathology Magnetic Resonance Imaging - methods Medicine Medicine & Public Health Neurosurgery Observer Variation Original Article Surgical Orthopedics |
| title | MRI T2 mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model |
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