A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3

Hepatitis C virus (HCV) infects hepatocytes and causes liver damage. The aim of this study was to identify new classes of host-targeting anti-HCV compounds that may provide novel approaches for antiviral treatment regimens. Cell culture-derived HCV (HCVcc), replicons and pseudoparticles were used in...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2015-07, Vol.70 (7), p.2013-2023
Hauptverfasser:	Niu, Yuqiang, Si, Youhui, Li, Yan, Chi, Xiaojing, Li, Xiang, Liu, Xiuying, Li, Duan, Cheng, Min, Fan, Jingjing, Si, Shuyi, Yang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Antiviral Agents - toxicity Antiviral drugs Cell culture Cell Line Cell Survival - drug effects Cytotoxicity Hepacivirus - physiology Hepatitis Hepatitis C Hepatitis C virus Hepatocytes - drug effects Hepatocytes - virology High-Throughput Screening Assays - methods Humans Molecules Phosphorylation STAT3 Transcription Factor - antagonists & inhibitors Virus Replication - drug effects
Online-Zugang:	Volltext
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