Neonatal Hypoxia-Ischemia Induces Attention-Deficit Hyperactivity Disorder-Like Behavior in Rats
Attention-deficit hyperactivity disorder (ADHD) may be caused by genetic or environmental factors. Among environmental factors, perinatal complications are related, such as neonatal hypoxia-ischemia (HI). Thus, the aim of this study was to investigate whether HI contributes to the development of cha...
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| Veröffentlicht in: | Behavioral neuroscience 2015-06, Vol.129 (3), p.309-320 |
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| creator | Miguel, Patrícia Maidana Schuch, Clarissa Pedrini Rojas, Joseane Jiménez Carletti, Jaqueline Vieira Deckmann, Iohanna Martinato, Luísa Helena Machado Pires, Augusto Viana Bizarro, Lisiane Pereira, Lenir Orlandi |
| description | Attention-deficit hyperactivity disorder (ADHD) may be caused by genetic or environmental factors. Among environmental factors, perinatal complications are related, such as neonatal hypoxia-ischemia (HI). Thus, the aim of this study was to investigate whether HI contributes to the development of characteristics related to ADHD in adult rats, and to correlate the behavioral results with brain damage volume. Male Wistar rats were divided into 2 groups: HI and control. The HI procedure consisted of a permanent occlusion of the right common carotid artery followed by a period of hypoxia (90 min; 8% O2 and 92% N2) on the 7th postnatal day. Two months later, animals were evaluated in the open field test during a single 5-min session, and in the 5-choice serial reaction time task (5-CSRTT), over 25 weeks. Our results demonstrated that animals submitted to HI manifest cognitive impairments in task acquisition, deficits in sustained attention, and increases in impulsivity and compulsivity in response to task manipulation in the 5-CSRTT. Locomotor activity observed in open field did not differ between groups. Moreover, brain volume loss in the total hemisphere, cerebral cortex, white matter, hippocampus, and striatum were observed in HI animals, especially on the side ipsilateral to the lesion. From these results, we can infer that neonatal HI is an environmental factor that could contribute to the development of behavioral characteristics observed in ADHD that are associated with general brain atrophy. |
| doi_str_mv | 10.1037/bne0000063 |
| format | Article |
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Among environmental factors, perinatal complications are related, such as neonatal hypoxia-ischemia (HI). Thus, the aim of this study was to investigate whether HI contributes to the development of characteristics related to ADHD in adult rats, and to correlate the behavioral results with brain damage volume. Male Wistar rats were divided into 2 groups: HI and control. The HI procedure consisted of a permanent occlusion of the right common carotid artery followed by a period of hypoxia (90 min; 8% O2 and 92% N2) on the 7th postnatal day. Two months later, animals were evaluated in the open field test during a single 5-min session, and in the 5-choice serial reaction time task (5-CSRTT), over 25 weeks. Our results demonstrated that animals submitted to HI manifest cognitive impairments in task acquisition, deficits in sustained attention, and increases in impulsivity and compulsivity in response to task manipulation in the 5-CSRTT. Locomotor activity observed in open field did not differ between groups. Moreover, brain volume loss in the total hemisphere, cerebral cortex, white matter, hippocampus, and striatum were observed in HI animals, especially on the side ipsilateral to the lesion. From these results, we can infer that neonatal HI is an environmental factor that could contribute to the development of behavioral characteristics observed in ADHD that are associated with general brain atrophy.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/bne0000063</identifier><identifier>PMID: 26030430</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Animal ; Animal behavior ; Animal Locomotion ; Animal Models ; Animals ; Animals, Newborn ; Anoxia ; Attention Deficit Disorder with Hyperactivity ; Attention Deficit Disorder with Hyperactivity - etiology ; Attention Deficit Disorder with Hyperactivity - pathology ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention deficit hyperactivity disorder ; Brain - pathology ; Brain - physiopathology ; Brain damage ; Carotid Artery Diseases ; Carotid Artery, Common ; Cerebral Atrophy ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Cognition Disorders - physiopathology ; Cognitive Impairment ; Compulsive Behavior - etiology ; Compulsive Behavior - pathology ; Compulsive Behavior - physiopathology ; Disease Models, Animal ; Hypoxia ; Hypoxia - complications ; Hypoxia - pathology ; Hypoxia - physiopathology ; Hypoxia-Ischemia, Brain - complications ; Hypoxia-Ischemia, Brain - pathology ; Hypoxia-Ischemia, Brain - physiopathology ; Impulsive Behavior - physiology ; Impulsiveness ; Ischemia ; Male ; Motor Activity - physiology ; Neuropsychological Tests ; Neuropsychology ; Organ Size ; Random Allocation ; Rats ; Rats, Wistar ; Rodents ; Sustained Attention</subject><ispartof>Behavioral neuroscience, 2015-06, Vol.129 (3), p.309-320</ispartof><rights>2015 American Psychological Association</rights><rights>(c) 2015 APA, all rights reserved).</rights><rights>2015, American Psychological Association</rights><rights>Copyright American Psychological Association Jun 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a413t-4e8f11f1558ab5f7bbf9dc6f2355ce9a65a0f15fb0f062f91f0d9ab9f69ca03</citedby><orcidid>0000-0002-6423-1938 ; 0000-0003-3070-5944</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26030430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Burwell, Rebecca D</contributor><creatorcontrib>Miguel, Patrícia Maidana</creatorcontrib><creatorcontrib>Schuch, Clarissa Pedrini</creatorcontrib><creatorcontrib>Rojas, Joseane Jiménez</creatorcontrib><creatorcontrib>Carletti, Jaqueline Vieira</creatorcontrib><creatorcontrib>Deckmann, Iohanna</creatorcontrib><creatorcontrib>Martinato, Luísa Helena Machado</creatorcontrib><creatorcontrib>Pires, Augusto Viana</creatorcontrib><creatorcontrib>Bizarro, Lisiane</creatorcontrib><creatorcontrib>Pereira, Lenir Orlandi</creatorcontrib><title>Neonatal Hypoxia-Ischemia Induces Attention-Deficit Hyperactivity Disorder-Like Behavior in Rats</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Attention-deficit hyperactivity disorder (ADHD) may be caused by genetic or environmental factors. Among environmental factors, perinatal complications are related, such as neonatal hypoxia-ischemia (HI). Thus, the aim of this study was to investigate whether HI contributes to the development of characteristics related to ADHD in adult rats, and to correlate the behavioral results with brain damage volume. Male Wistar rats were divided into 2 groups: HI and control. The HI procedure consisted of a permanent occlusion of the right common carotid artery followed by a period of hypoxia (90 min; 8% O2 and 92% N2) on the 7th postnatal day. Two months later, animals were evaluated in the open field test during a single 5-min session, and in the 5-choice serial reaction time task (5-CSRTT), over 25 weeks. Our results demonstrated that animals submitted to HI manifest cognitive impairments in task acquisition, deficits in sustained attention, and increases in impulsivity and compulsivity in response to task manipulation in the 5-CSRTT. Locomotor activity observed in open field did not differ between groups. Moreover, brain volume loss in the total hemisphere, cerebral cortex, white matter, hippocampus, and striatum were observed in HI animals, especially on the side ipsilateral to the lesion. From these results, we can infer that neonatal HI is an environmental factor that could contribute to the development of behavioral characteristics observed in ADHD that are associated with general brain atrophy.</description><subject>Animal</subject><subject>Animal behavior</subject><subject>Animal Locomotion</subject><subject>Animal Models</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Anoxia</subject><subject>Attention Deficit Disorder with Hyperactivity</subject><subject>Attention Deficit Disorder with Hyperactivity - etiology</subject><subject>Attention Deficit Disorder with Hyperactivity - pathology</subject><subject>Attention Deficit Disorder with Hyperactivity - physiopathology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain damage</subject><subject>Carotid Artery Diseases</subject><subject>Carotid Artery, Common</subject><subject>Cerebral Atrophy</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognitive Impairment</subject><subject>Compulsive Behavior - etiology</subject><subject>Compulsive Behavior - pathology</subject><subject>Compulsive Behavior - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Hypoxia</subject><subject>Hypoxia - complications</subject><subject>Hypoxia - pathology</subject><subject>Hypoxia - physiopathology</subject><subject>Hypoxia-Ischemia, Brain - complications</subject><subject>Hypoxia-Ischemia, Brain - pathology</subject><subject>Hypoxia-Ischemia, Brain - physiopathology</subject><subject>Impulsive Behavior - physiology</subject><subject>Impulsiveness</subject><subject>Ischemia</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Organ Size</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sustained Attention</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0UGL1DAYxvEgijuuXvwAUvAiYvVNk7TNcd1Vd2BQUO_xbfqGzdppukm6ON_ellkVPIi55JAfD4Q_Y085vOYgmjfdSLCeWtxjG66FLgFaeZ9toBGqbEDKE_YopeuFSJDqITupahAgBWzYt48URsw4FJeHKfzwWG6TvaK9x2I79rOlVJzlTGP2YSwvyHnr80opos3-1udDceFTiD3Fcue_U_GWrvDWh1j4sfiMOT1mDxwOiZ7c3afsy_t3X88vy92nD9vzs12JkotcSmod544r1WKnXNN1Tve2dpVQypLGWiEsr64DB3XlNHfQa-y0q7VFEKfsxXF1iuFmppTN3idLw4AjhTkZ3vCqaSpR_QetW9VIXdcrff4XvQ5zHJdvLIOgeCtFpf6p1i21NGoX9fKobAwpRXJmin6P8WA4mDWj-ZNxwc_uJuduT_1v-qvbAl4dAU5opnSwGLO3AyU7x7jUWscMr7QRRoAWPwGF_KaB</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Miguel, Patrícia Maidana</creator><creator>Schuch, Clarissa Pedrini</creator><creator>Rojas, Joseane Jiménez</creator><creator>Carletti, Jaqueline Vieira</creator><creator>Deckmann, Iohanna</creator><creator>Martinato, Luísa Helena Machado</creator><creator>Pires, Augusto Viana</creator><creator>Bizarro, Lisiane</creator><creator>Pereira, Lenir Orlandi</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6423-1938</orcidid><orcidid>https://orcid.org/0000-0003-3070-5944</orcidid></search><sort><creationdate>20150601</creationdate><title>Neonatal Hypoxia-Ischemia Induces Attention-Deficit Hyperactivity Disorder-Like Behavior in Rats</title><author>Miguel, Patrícia Maidana ; Schuch, Clarissa Pedrini ; Rojas, Joseane Jiménez ; Carletti, Jaqueline Vieira ; Deckmann, Iohanna ; Martinato, Luísa Helena Machado ; Pires, Augusto Viana ; Bizarro, Lisiane ; Pereira, Lenir Orlandi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a413t-4e8f11f1558ab5f7bbf9dc6f2355ce9a65a0f15fb0f062f91f0d9ab9f69ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animal</topic><topic>Animal behavior</topic><topic>Animal Locomotion</topic><topic>Animal Models</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Anoxia</topic><topic>Attention Deficit Disorder with Hyperactivity</topic><topic>Attention Deficit Disorder with Hyperactivity - etiology</topic><topic>Attention Deficit Disorder with Hyperactivity - pathology</topic><topic>Attention Deficit Disorder with Hyperactivity - physiopathology</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain damage</topic><topic>Carotid Artery Diseases</topic><topic>Carotid Artery, Common</topic><topic>Cerebral Atrophy</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognitive Impairment</topic><topic>Compulsive Behavior - etiology</topic><topic>Compulsive Behavior - pathology</topic><topic>Compulsive Behavior - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Hypoxia</topic><topic>Hypoxia - complications</topic><topic>Hypoxia - pathology</topic><topic>Hypoxia - physiopathology</topic><topic>Hypoxia-Ischemia, Brain - complications</topic><topic>Hypoxia-Ischemia, Brain - pathology</topic><topic>Hypoxia-Ischemia, Brain - physiopathology</topic><topic>Impulsive Behavior - physiology</topic><topic>Impulsiveness</topic><topic>Ischemia</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Organ Size</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sustained Attention</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miguel, Patrícia Maidana</creatorcontrib><creatorcontrib>Schuch, Clarissa Pedrini</creatorcontrib><creatorcontrib>Rojas, Joseane Jiménez</creatorcontrib><creatorcontrib>Carletti, Jaqueline Vieira</creatorcontrib><creatorcontrib>Deckmann, Iohanna</creatorcontrib><creatorcontrib>Martinato, Luísa Helena Machado</creatorcontrib><creatorcontrib>Pires, Augusto Viana</creatorcontrib><creatorcontrib>Bizarro, Lisiane</creatorcontrib><creatorcontrib>Pereira, Lenir Orlandi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miguel, Patrícia Maidana</au><au>Schuch, Clarissa Pedrini</au><au>Rojas, Joseane Jiménez</au><au>Carletti, Jaqueline Vieira</au><au>Deckmann, Iohanna</au><au>Martinato, Luísa Helena Machado</au><au>Pires, Augusto Viana</au><au>Bizarro, Lisiane</au><au>Pereira, Lenir Orlandi</au><au>Burwell, Rebecca D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal Hypoxia-Ischemia Induces Attention-Deficit Hyperactivity Disorder-Like Behavior in Rats</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>129</volume><issue>3</issue><spage>309</spage><epage>320</epage><pages>309-320</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><abstract>Attention-deficit hyperactivity disorder (ADHD) may be caused by genetic or environmental factors. Among environmental factors, perinatal complications are related, such as neonatal hypoxia-ischemia (HI). Thus, the aim of this study was to investigate whether HI contributes to the development of characteristics related to ADHD in adult rats, and to correlate the behavioral results with brain damage volume. Male Wistar rats were divided into 2 groups: HI and control. The HI procedure consisted of a permanent occlusion of the right common carotid artery followed by a period of hypoxia (90 min; 8% O2 and 92% N2) on the 7th postnatal day. Two months later, animals were evaluated in the open field test during a single 5-min session, and in the 5-choice serial reaction time task (5-CSRTT), over 25 weeks. Our results demonstrated that animals submitted to HI manifest cognitive impairments in task acquisition, deficits in sustained attention, and increases in impulsivity and compulsivity in response to task manipulation in the 5-CSRTT. Locomotor activity observed in open field did not differ between groups. Moreover, brain volume loss in the total hemisphere, cerebral cortex, white matter, hippocampus, and striatum were observed in HI animals, especially on the side ipsilateral to the lesion. From these results, we can infer that neonatal HI is an environmental factor that could contribute to the development of behavioral characteristics observed in ADHD that are associated with general brain atrophy.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>26030430</pmid><doi>10.1037/bne0000063</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6423-1938</orcidid><orcidid>https://orcid.org/0000-0003-3070-5944</orcidid></addata></record> |
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| subjects | Animal Animal behavior Animal Locomotion Animal Models Animals Animals, Newborn Anoxia Attention Deficit Disorder with Hyperactivity Attention Deficit Disorder with Hyperactivity - etiology Attention Deficit Disorder with Hyperactivity - pathology Attention Deficit Disorder with Hyperactivity - physiopathology Attention deficit hyperactivity disorder Brain - pathology Brain - physiopathology Brain damage Carotid Artery Diseases Carotid Artery, Common Cerebral Atrophy Cognition Disorders - etiology Cognition Disorders - pathology Cognition Disorders - physiopathology Cognitive Impairment Compulsive Behavior - etiology Compulsive Behavior - pathology Compulsive Behavior - physiopathology Disease Models, Animal Hypoxia Hypoxia - complications Hypoxia - pathology Hypoxia - physiopathology Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - pathology Hypoxia-Ischemia, Brain - physiopathology Impulsive Behavior - physiology Impulsiveness Ischemia Male Motor Activity - physiology Neuropsychological Tests Neuropsychology Organ Size Random Allocation Rats Rats, Wistar Rodents Sustained Attention |
| title | Neonatal Hypoxia-Ischemia Induces Attention-Deficit Hyperactivity Disorder-Like Behavior in Rats |
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