Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed
Abstract The National Smallpox Vaccine in Pregnancy Registry (NSVIPR) actively follows women inadvertently vaccinated with smallpox vaccine during or shortly before pregnancy to evaluate their reproductive health outcomes. Approximately 65% of NSVIPR participants also inadvertently received Anthrax...
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| Veröffentlicht in: | Vaccine 2015-08, Vol.33 (36), p.4387-4390 |
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| creator | Conlin, Ava Marie S Bukowinski, Anna T Gumbs, Gia R |
| description | Abstract The National Smallpox Vaccine in Pregnancy Registry (NSVIPR) actively follows women inadvertently vaccinated with smallpox vaccine during or shortly before pregnancy to evaluate their reproductive health outcomes. Approximately 65% of NSVIPR participants also inadvertently received Anthrax Vaccine Adsorbed (AVA) while pregnant, providing a ready opportunity to evaluate pregnancy and infant health outcomes among these women. AVA-exposed pregnancies were ascertained using NSVIPR and electronic healthcare data. Rates of pregnancy loss and infant health outcomes, including major birth defects, were compared between AVA-exposed and AVA-unexposed pregnancies. Analyses included AVA-exposed and AVA-unexposed pregnant women who also received smallpox vaccine 28 days prior to or during pregnancy. Rates of adverse outcomes among the AVA-exposed group were similar to or lower than expected when compared with published reference rates and the AVA-unexposed population. The findings provide reassurance of the safety of AVA when inadvertently received by a relatively young and healthy population during pregnancy. |
| doi_str_mv | 10.1016/j.vaccine.2015.05.054 |
| format | Article |
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Approximately 65% of NSVIPR participants also inadvertently received Anthrax Vaccine Adsorbed (AVA) while pregnant, providing a ready opportunity to evaluate pregnancy and infant health outcomes among these women. AVA-exposed pregnancies were ascertained using NSVIPR and electronic healthcare data. Rates of pregnancy loss and infant health outcomes, including major birth defects, were compared between AVA-exposed and AVA-unexposed pregnancies. Analyses included AVA-exposed and AVA-unexposed pregnant women who also received smallpox vaccine 28 days prior to or during pregnancy. Rates of adverse outcomes among the AVA-exposed group were similar to or lower than expected when compared with published reference rates and the AVA-unexposed population. The findings provide reassurance of the safety of AVA when inadvertently received by a relatively young and healthy population during pregnancy.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2015.05.054</identifier><identifier>PMID: 26049005</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Allergy and Immunology ; Anthrax Vaccine Adsorbed (AVA) ; Anthrax Vaccines - administration & dosage ; Anthrax Vaccines - adverse effects ; Birth defects ; Birth weight ; Congenital abnormalities ; Female ; Humans ; Immunization ; Infant ; Infant Health ; Infant, Newborn ; Infants ; Male ; Maternal Exposure ; Pregnancy ; Pregnancy Outcome ; Reproductive health ; Smallpox ; Smallpox Vaccine - administration & dosage ; Smallpox Vaccine - adverse effects ; Vaccines ; Womens health ; Young Adult</subject><ispartof>Vaccine, 2015-08, Vol.33 (36), p.4387-4390</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 26, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-186c5fc5ffb2ba6824b1adcdaeec23aa37bf39695e20a8b88db467439340dccf3</citedby><cites>FETCH-LOGICAL-c551t-186c5fc5ffb2ba6824b1adcdaeec23aa37bf39695e20a8b88db467439340dccf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1708139090?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26049005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conlin, Ava Marie S</creatorcontrib><creatorcontrib>Bukowinski, Anna T</creatorcontrib><creatorcontrib>Gumbs, Gia R</creatorcontrib><creatorcontrib>for the Department of Defense Birth and Infant Health Registry Team</creatorcontrib><creatorcontrib>Department of Defense Birth and Infant Health Registry Team</creatorcontrib><title>Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract The National Smallpox Vaccine in Pregnancy Registry (NSVIPR) actively follows women inadvertently vaccinated with smallpox vaccine during or shortly before pregnancy to evaluate their reproductive health outcomes. Approximately 65% of NSVIPR participants also inadvertently received Anthrax Vaccine Adsorbed (AVA) while pregnant, providing a ready opportunity to evaluate pregnancy and infant health outcomes among these women. AVA-exposed pregnancies were ascertained using NSVIPR and electronic healthcare data. Rates of pregnancy loss and infant health outcomes, including major birth defects, were compared between AVA-exposed and AVA-unexposed pregnancies. Analyses included AVA-exposed and AVA-unexposed pregnant women who also received smallpox vaccine 28 days prior to or during pregnancy. Rates of adverse outcomes among the AVA-exposed group were similar to or lower than expected when compared with published reference rates and the AVA-unexposed population. The findings provide reassurance of the safety of AVA when inadvertently received by a relatively young and healthy population during pregnancy.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Anthrax Vaccine Adsorbed (AVA)</subject><subject>Anthrax Vaccines - administration & dosage</subject><subject>Anthrax Vaccines - adverse effects</subject><subject>Birth defects</subject><subject>Birth weight</subject><subject>Congenital abnormalities</subject><subject>Female</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infant Health</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Reproductive health</subject><subject>Smallpox</subject><subject>Smallpox Vaccine - administration & dosage</subject><subject>Smallpox Vaccine - adverse effects</subject><subject>Vaccines</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkt2KFDEQhRtR3NnVR1AC3njTYyXp3xtlWPyDRcVV8S6kk-qZjN3JmHTPbj-Kb2vaGXdhbxQKksBXJ8k5lSRPKCwp0OLFdrmXShmLSwY0X8Jc2b1kQauSpyyn1f1kAazI0ozC95PkNIQtAOSc1g-TE1ZAVsfTIvm1srKbggnEtWTncW2lVRORVhNjW2kHskHZDRvixkG5HgORvbNrchX3NiJk2CD5IAfjog657GXX7dw1-XZ42wx8uhH9jGsTBj-Rq40jHhWaPWqyssPGy9uWlQ7ON6gfJQ9a2QV8fFzPkq9vXn85f5defHz7_nx1kao8p0NKq0Llbay2YY0sKpY1VGqlJaJiXEpeNi2vizpHBrJqqko3WVFmvOYZaKVafpY8P-juvPs5YhhEb4LCrpMW3RgELSkrS8hY-R8oFHlZ8YpH9NkddOtGHz36Q1WU11BDpPIDpbwLwWMrdt700k-CgphjFltxjFnMMQuYK4t9T4_qY9Ojvun6m2sEXh0AjM7tDXoRlEGrUJto_CC0M_-84uUdBdUZa5TsfuCE4fY3IjAB4nKetXnUaA5Q0pLz317O0rg</recordid><startdate>20150826</startdate><enddate>20150826</enddate><creator>Conlin, Ava Marie S</creator><creator>Bukowinski, Anna T</creator><creator>Gumbs, Gia R</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150826</creationdate><title>Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed</title><author>Conlin, Ava Marie S ; Bukowinski, Anna T ; Gumbs, Gia R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-186c5fc5ffb2ba6824b1adcdaeec23aa37bf39695e20a8b88db467439340dccf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Anthrax Vaccine Adsorbed (AVA)</topic><topic>Anthrax Vaccines - administration & dosage</topic><topic>Anthrax Vaccines - adverse effects</topic><topic>Birth defects</topic><topic>Birth weight</topic><topic>Congenital abnormalities</topic><topic>Female</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant</topic><topic>Infant Health</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Male</topic><topic>Maternal Exposure</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Reproductive health</topic><topic>Smallpox</topic><topic>Smallpox Vaccine - administration & dosage</topic><topic>Smallpox Vaccine - adverse effects</topic><topic>Vaccines</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conlin, Ava Marie S</creatorcontrib><creatorcontrib>Bukowinski, Anna T</creatorcontrib><creatorcontrib>Gumbs, Gia R</creatorcontrib><creatorcontrib>for the Department of Defense Birth and Infant Health Registry Team</creatorcontrib><creatorcontrib>Department of Defense Birth and Infant Health Registry Team</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conlin, Ava Marie S</au><au>Bukowinski, Anna T</au><au>Gumbs, Gia R</au><aucorp>for the Department of Defense Birth and Infant Health Registry Team</aucorp><aucorp>Department of Defense Birth and Infant Health Registry Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2015-08-26</date><risdate>2015</risdate><volume>33</volume><issue>36</issue><spage>4387</spage><epage>4390</epage><pages>4387-4390</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Abstract The National Smallpox Vaccine in Pregnancy Registry (NSVIPR) actively follows women inadvertently vaccinated with smallpox vaccine during or shortly before pregnancy to evaluate their reproductive health outcomes. Approximately 65% of NSVIPR participants also inadvertently received Anthrax Vaccine Adsorbed (AVA) while pregnant, providing a ready opportunity to evaluate pregnancy and infant health outcomes among these women. AVA-exposed pregnancies were ascertained using NSVIPR and electronic healthcare data. Rates of pregnancy loss and infant health outcomes, including major birth defects, were compared between AVA-exposed and AVA-unexposed pregnancies. Analyses included AVA-exposed and AVA-unexposed pregnant women who also received smallpox vaccine 28 days prior to or during pregnancy. Rates of adverse outcomes among the AVA-exposed group were similar to or lower than expected when compared with published reference rates and the AVA-unexposed population. The findings provide reassurance of the safety of AVA when inadvertently received by a relatively young and healthy population during pregnancy.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26049005</pmid><doi>10.1016/j.vaccine.2015.05.054</doi><tpages>4</tpages></addata></record> |
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| ispartof | Vaccine, 2015-08, Vol.33 (36), p.4387-4390 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Adult Allergy and Immunology Anthrax Vaccine Adsorbed (AVA) Anthrax Vaccines - administration & dosage Anthrax Vaccines - adverse effects Birth defects Birth weight Congenital abnormalities Female Humans Immunization Infant Infant Health Infant, Newborn Infants Male Maternal Exposure Pregnancy Pregnancy Outcome Reproductive health Smallpox Smallpox Vaccine - administration & dosage Smallpox Vaccine - adverse effects Vaccines Womens health Young Adult |
| title | Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed |
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