Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells

Type 2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. Here, we report that Bcl11b, previously considered a T-cell-specific transcription factor, acted directly upstream of the key ILC2 transcription factor Gfi1 to maintain its expression in mature ILC2s. C...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-08, Vol.43 (2), p.354-368
Hauptverfasser:	Califano, Danielle, Cho, Jonathan J., Uddin, Mohammad N., Lorentsen, Kyle J., Yang, Qi, Bhandoola, Avinash, Li, Hongmin, Avram, Dorina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Cell Differentiation Cell Lineage Cell Movement - genetics Cells, Cultured Citrobacter rodentium - immunology Confidence intervals Cytokines DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enterobacteriaceae Infections - immunology Eosinophils - immunology GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene expression Gene Expression Regulation - genetics Genomes Immunity, Innate Interleukin-1 Receptor-Like 1 Protein Lymphocyte Subsets - immunology Lymphocytes Lymphocytes - immunology Mice Mice, Inbred Strains Neutrophils - immunology Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Receptors, Aryl Hydrocarbon - genetics Receptors, Interleukin - genetics Repressor Proteins - genetics Repressor Proteins - metabolism Rodents Th2 Cells - immunology Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Viral infections
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