Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway
Highlights • Our results show that minocycline reduces hypoxia-induced increases in BBB permeability and HIF-1α. • Minocycline also increases the hypoxia-induced reduction of PHD-2 and SIRT-3. • These effects of minocycline are abolished by siRNA-mediated knockdown of SIRT-3 in the brain. • Minocycl...
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| Veröffentlicht in: | Neuroscience 2015-09, Vol.304, p.250-259 |
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| creator | Yang, F Zhou, L Wang, D Wang, Z Huang, Q.-Y |
| description | Highlights • Our results show that minocycline reduces hypoxia-induced increases in BBB permeability and HIF-1α. • Minocycline also increases the hypoxia-induced reduction of PHD-2 and SIRT-3. • These effects of minocycline are abolished by siRNA-mediated knockdown of SIRT-3 in the brain. • Minocycline inhibits HIF-1α-mediated cellular responses and protects the BBB through a SIRT-3/PHD-2-dependent pathway. |
| doi_str_mv | 10.1016/j.neuroscience.2015.07.051 |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-67fa59ea16c3b3c266595c5e3c89aa2351b4b32b40f82c6e036ae58180735f1d3</citedby><cites>FETCH-LOGICAL-c468t-67fa59ea16c3b3c266595c5e3c89aa2351b4b32b40f82c6e036ae58180735f1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2015.07.051$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26211444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, F</creatorcontrib><creatorcontrib>Zhou, L</creatorcontrib><creatorcontrib>Wang, D</creatorcontrib><creatorcontrib>Wang, Z</creatorcontrib><creatorcontrib>Huang, Q.-Y</creatorcontrib><title>Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • Our results show that minocycline reduces hypoxia-induced increases in BBB permeability and HIF-1α. • Minocycline also increases the hypoxia-induced reduction of PHD-2 and SIRT-3. • These effects of minocycline are abolished by siRNA-mediated knockdown of SIRT-3 in the brain. • Minocycline inhibits HIF-1α-mediated cellular responses and protects the BBB through a SIRT-3/PHD-2-dependent pathway.</description><subject>Animals</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Blood-Brain Barrier - pathology</subject><subject>blood–brain barrier</subject><subject>Cell Hypoxia - drug effects</subject><subject>Cell Hypoxia - physiology</subject><subject>Cells, Cultured</subject><subject>Disease Models, Animal</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - pathology</subject><subject>Gene Knockdown Techniques</subject><subject>HIF-1α</subject><subject>hypoxia</subject><subject>Hypoxia, Brain - drug therapy</subject><subject>Hypoxia, Brain - metabolism</subject><subject>Hypoxia, Brain - pathology</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</subject><subject>Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism</subject><subject>Male</subject><subject>minocycline</subject><subject>Minocycline - pharmacology</subject><subject>neuro-inflammation</subject><subject>Neurology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Procollagen-Proline Dioxygenase - metabolism</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Small Interfering</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><subject>SIRT-3</subject><subject>Sirtuin 3 - genetics</subject><subject>Sirtuin 3 - metabolism</subject><subject>Sirtuins - genetics</subject><subject>Sirtuins - metabolism</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9u1DAUhy0EotPCFZDFik1S_0-GBRJqKTNSEYgWiZ3lOC8TD0k82Ak0O1ZcgJNwEQ7BSUiYASFW9cab7_2e9PseQo8pSSmh6nSbdjAEH62DzkLKCJUpyVIi6R20oHnGk0wKcRctCCcqEZKxI3Qc45ZMTwp-Hx0xxSgVQizQ11eu83a0jesAmxYa54PpIeJ63PkbZxLXlYOFEheN9-XPL9-KYFyHCxOCg4BL05oN4GLErqtd4XrnO-wrvFpfJPTHd9zXwQ-bGl-t314n_PTN6jxhuIRNMKX5ze5MX3824wN0rzJNhIeH_wS9u3hxfbZKLl-_XJ89v0ysUHmfqKwycgmGKssLbplScimtBG7zpTGMS1qIgrNCkCpnVgHhyoDMaU4yLita8hP0ZJ-7C_7jALHXrYsWmsZ04IeoaUZZpnLB8lugRMksVxmd0Kd71E5WYoBK74JrTRg1JXpWprf6X2V6VqZJpidl0_Cjw56haKH8O_rH0QSc7wGYivk0ta4PMaULYHtdene7Pc_-i5mlO2uaDzBC3PohdFP1murINNFX8_HMt0MlIVPP7_kvHXPFUw</recordid><startdate>20150924</startdate><enddate>20150924</enddate><creator>Yang, F</creator><creator>Zhou, L</creator><creator>Wang, D</creator><creator>Wang, Z</creator><creator>Huang, Q.-Y</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20150924</creationdate><title>Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway</title><author>Yang, F ; Zhou, L ; Wang, D ; Wang, Z ; Huang, Q.-Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-67fa59ea16c3b3c266595c5e3c89aa2351b4b32b40f82c6e036ae58180735f1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>Blood-Brain Barrier - pathology</topic><topic>blood–brain barrier</topic><topic>Cell Hypoxia - drug effects</topic><topic>Cell Hypoxia - physiology</topic><topic>Cells, Cultured</topic><topic>Disease Models, Animal</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - pathology</topic><topic>Gene Knockdown Techniques</topic><topic>HIF-1α</topic><topic>hypoxia</topic><topic>Hypoxia, Brain - drug therapy</topic><topic>Hypoxia, Brain - metabolism</topic><topic>Hypoxia, Brain - pathology</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</topic><topic>Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism</topic><topic>Male</topic><topic>minocycline</topic><topic>Minocycline - pharmacology</topic><topic>neuro-inflammation</topic><topic>Neurology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Procollagen-Proline Dioxygenase - metabolism</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Small Interfering</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><topic>SIRT-3</topic><topic>Sirtuin 3 - genetics</topic><topic>Sirtuin 3 - metabolism</topic><topic>Sirtuins - genetics</topic><topic>Sirtuins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, F</creatorcontrib><creatorcontrib>Zhou, L</creatorcontrib><creatorcontrib>Wang, D</creatorcontrib><creatorcontrib>Wang, Z</creatorcontrib><creatorcontrib>Huang, Q.-Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, F</au><au>Zhou, L</au><au>Wang, D</au><au>Wang, Z</au><au>Huang, Q.-Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2015-09-24</date><risdate>2015</risdate><volume>304</volume><spage>250</spage><epage>259</epage><pages>250-259</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • Our results show that minocycline reduces hypoxia-induced increases in BBB permeability and HIF-1α. • Minocycline also increases the hypoxia-induced reduction of PHD-2 and SIRT-3. • These effects of minocycline are abolished by siRNA-mediated knockdown of SIRT-3 in the brain. • Minocycline inhibits HIF-1α-mediated cellular responses and protects the BBB through a SIRT-3/PHD-2-dependent pathway.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>26211444</pmid><doi>10.1016/j.neuroscience.2015.07.051</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology blood–brain barrier Cell Hypoxia - drug effects Cell Hypoxia - physiology Cells, Cultured Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Gene Knockdown Techniques HIF-1α hypoxia Hypoxia, Brain - drug therapy Hypoxia, Brain - metabolism Hypoxia, Brain - pathology Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism Male minocycline Minocycline - pharmacology neuro-inflammation Neurology Neuroprotective Agents - pharmacology Procollagen-Proline Dioxygenase - metabolism Rats, Sprague-Dawley RNA, Messenger - metabolism RNA, Small Interfering Signal Transduction - drug effects Signal Transduction - physiology SIRT-3 Sirtuin 3 - genetics Sirtuin 3 - metabolism Sirtuins - genetics Sirtuins - metabolism |
| title | Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway |
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