White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures
Abstract The purpose of this study was to conduct a preliminary investigation of the white matter characteristics in patients with psychogenic non-epileptic seizures (PNES). Diffusion Tensor Imaging (DTI) data were collected at 3 T in 16 patients with PNES and 16 age- and sex-matched healthy control...
Gespeichert in:
| Veröffentlicht in: | Brain research 2015-09, Vol.1620, p.169-176 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 176 |
|---|---|
| container_issue | |
| container_start_page | 169 |
| container_title | Brain research |
| container_volume | 1620 |
| creator | Lee, Seongtaek Allendorfer, Jane B Gaston, Tyler E Griffis, Joseph C Hernando, Kathleen A Knowlton, Robert C Szaflarski, Jerzy P Ver Hoef, Lawrence W |
| description | Abstract The purpose of this study was to conduct a preliminary investigation of the white matter characteristics in patients with psychogenic non-epileptic seizures (PNES). Diffusion Tensor Imaging (DTI) data were collected at 3 T in 16 patients with PNES and 16 age- and sex-matched healthy controls (HC). All patients with PNES had their diagnosis confirmed via video/EEG monitoring; HCs had no comorbid neurological or psychiatric conditions. DTI indices including fractional anisotropy (FA), and mean diffusivity (MD) were calculated and compared between patients with PNES and HCs using Tract-Based Spatial Statistics (TBSS). Significantly higher FA values were observed in patients with PNES in the left corona radiata, left internal and external capsules, left superior temporal gyrus, as well as left uncinate fasciculus (UF) ( P |
| doi_str_mv | 10.1016/j.brainres.2015.04.050 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1712768404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899315003534</els_id><sourcerecordid>1712768404</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-d63db302d0e9a4eff991052f105bf2710048df6577be6f8fc0efe399909c14bd3</originalsourceid><addsrcrecordid>eNqNUk1v1DAQtRCILoW_UOXIJek4dj58QaCqUKRKHADBzXLsMeslcYLtgLa_vl625dBLuYxnpDfzrPceIWcUKgq0Pd9VQ1DOB4xVDbSpgFfQwBOyoX1Xl23N4SnZAEBb9kKwE_Iixl0eGRPwnJzUjegEo3RDvn_buoTFpFLCUBhn7Rrd7As1-DlManTJYSycLxaVO59i8celbbHEvd7OP9A7XfjZl7i4EZeUp4juZs3fekmeWTVGfHX3npKv7y-_XFyV158-fLx4d11q3otUmpaZgUFtAIXiaK0QFJra5jLYuqMAvDe2bbpuwNb2VgNaZEIIEJrywbBT8vp4dwnzrxVjkpOLGsdReZzXKGlH667tOfD_gEImarq_0PYI1WGOMaCVS3CTCntJQR4MkDt5b4A8GCCBy2xAXjy741iHCc2_tXvFM-DtEYBZlN8Og4w6C6vRuIA6STO7xznePDihR5edUONP3GPczWvwWXJJZawlyM-HGBxSQJscgIZxdgtwUbCZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1706575704</pqid></control><display><type>article</type><title>White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Lee, Seongtaek ; Allendorfer, Jane B ; Gaston, Tyler E ; Griffis, Joseph C ; Hernando, Kathleen A ; Knowlton, Robert C ; Szaflarski, Jerzy P ; Ver Hoef, Lawrence W</creator><creatorcontrib>Lee, Seongtaek ; Allendorfer, Jane B ; Gaston, Tyler E ; Griffis, Joseph C ; Hernando, Kathleen A ; Knowlton, Robert C ; Szaflarski, Jerzy P ; Ver Hoef, Lawrence W</creatorcontrib><description>Abstract The purpose of this study was to conduct a preliminary investigation of the white matter characteristics in patients with psychogenic non-epileptic seizures (PNES). Diffusion Tensor Imaging (DTI) data were collected at 3 T in 16 patients with PNES and 16 age- and sex-matched healthy controls (HC). All patients with PNES had their diagnosis confirmed via video/EEG monitoring; HCs had no comorbid neurological or psychiatric conditions. DTI indices including fractional anisotropy (FA), and mean diffusivity (MD) were calculated and compared between patients with PNES and HCs using Tract-Based Spatial Statistics (TBSS). Significantly higher FA values were observed in patients with PNES in the left corona radiata, left internal and external capsules, left superior temporal gyrus, as well as left uncinate fasciculus (UF) ( P <0.05; corrected for multiple comparisons). There was no significant change in other indices between patients with PNES and HCs. These findings suggest that patients with PNES have significantly altered white matter structural connectivity when compared to age- and sex-matched HCs. These abnormalities are present in left hemispheric regions associated with emotion regulation and motor pathways. While the relationship between the pathophysiology of PNES and these abnormalities is not entirely clear, this work provides an initial basis to guide future prospective studies.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2015.04.050</identifier><identifier>PMID: 25979311</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Anisotropy ; Brain - pathology ; Diffusion Tensor Imaging ; Diffusion tensor imaging (DTI) ; Female ; Humans ; Male ; Middle Aged ; Neurology ; Psychogenic non-epileptic seizures (PNES) ; Psychophysiologic Disorders - pathology ; Seizures - pathology ; Superior temporal gyrus (STG) ; Tract-based spatial statistics (TBSS) ; Uncinate fasciculus (UF) ; White Matter - pathology ; Young Adult</subject><ispartof>Brain research, 2015-09, Vol.1620, p.169-176</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-d63db302d0e9a4eff991052f105bf2710048df6577be6f8fc0efe399909c14bd3</citedby><cites>FETCH-LOGICAL-c489t-d63db302d0e9a4eff991052f105bf2710048df6577be6f8fc0efe399909c14bd3</cites><orcidid>0000-0001-8954-6103</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2015.04.050$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25979311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seongtaek</creatorcontrib><creatorcontrib>Allendorfer, Jane B</creatorcontrib><creatorcontrib>Gaston, Tyler E</creatorcontrib><creatorcontrib>Griffis, Joseph C</creatorcontrib><creatorcontrib>Hernando, Kathleen A</creatorcontrib><creatorcontrib>Knowlton, Robert C</creatorcontrib><creatorcontrib>Szaflarski, Jerzy P</creatorcontrib><creatorcontrib>Ver Hoef, Lawrence W</creatorcontrib><title>White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract The purpose of this study was to conduct a preliminary investigation of the white matter characteristics in patients with psychogenic non-epileptic seizures (PNES). Diffusion Tensor Imaging (DTI) data were collected at 3 T in 16 patients with PNES and 16 age- and sex-matched healthy controls (HC). All patients with PNES had their diagnosis confirmed via video/EEG monitoring; HCs had no comorbid neurological or psychiatric conditions. DTI indices including fractional anisotropy (FA), and mean diffusivity (MD) were calculated and compared between patients with PNES and HCs using Tract-Based Spatial Statistics (TBSS). Significantly higher FA values were observed in patients with PNES in the left corona radiata, left internal and external capsules, left superior temporal gyrus, as well as left uncinate fasciculus (UF) ( P <0.05; corrected for multiple comparisons). There was no significant change in other indices between patients with PNES and HCs. These findings suggest that patients with PNES have significantly altered white matter structural connectivity when compared to age- and sex-matched HCs. These abnormalities are present in left hemispheric regions associated with emotion regulation and motor pathways. While the relationship between the pathophysiology of PNES and these abnormalities is not entirely clear, this work provides an initial basis to guide future prospective studies.</description><subject>Adult</subject><subject>Anisotropy</subject><subject>Brain - pathology</subject><subject>Diffusion Tensor Imaging</subject><subject>Diffusion tensor imaging (DTI)</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Psychogenic non-epileptic seizures (PNES)</subject><subject>Psychophysiologic Disorders - pathology</subject><subject>Seizures - pathology</subject><subject>Superior temporal gyrus (STG)</subject><subject>Tract-based spatial statistics (TBSS)</subject><subject>Uncinate fasciculus (UF)</subject><subject>White Matter - pathology</subject><subject>Young Adult</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQtRCILoW_UOXIJek4dj58QaCqUKRKHADBzXLsMeslcYLtgLa_vl625dBLuYxnpDfzrPceIWcUKgq0Pd9VQ1DOB4xVDbSpgFfQwBOyoX1Xl23N4SnZAEBb9kKwE_Iixl0eGRPwnJzUjegEo3RDvn_buoTFpFLCUBhn7Rrd7As1-DlManTJYSycLxaVO59i8celbbHEvd7OP9A7XfjZl7i4EZeUp4juZs3fekmeWTVGfHX3npKv7y-_XFyV158-fLx4d11q3otUmpaZgUFtAIXiaK0QFJra5jLYuqMAvDe2bbpuwNb2VgNaZEIIEJrywbBT8vp4dwnzrxVjkpOLGsdReZzXKGlH667tOfD_gEImarq_0PYI1WGOMaCVS3CTCntJQR4MkDt5b4A8GCCBy2xAXjy741iHCc2_tXvFM-DtEYBZlN8Og4w6C6vRuIA6STO7xznePDihR5edUONP3GPczWvwWXJJZawlyM-HGBxSQJscgIZxdgtwUbCZ</recordid><startdate>20150916</startdate><enddate>20150916</enddate><creator>Lee, Seongtaek</creator><creator>Allendorfer, Jane B</creator><creator>Gaston, Tyler E</creator><creator>Griffis, Joseph C</creator><creator>Hernando, Kathleen A</creator><creator>Knowlton, Robert C</creator><creator>Szaflarski, Jerzy P</creator><creator>Ver Hoef, Lawrence W</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><orcidid>https://orcid.org/0000-0001-8954-6103</orcidid></search><sort><creationdate>20150916</creationdate><title>White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures</title><author>Lee, Seongtaek ; Allendorfer, Jane B ; Gaston, Tyler E ; Griffis, Joseph C ; Hernando, Kathleen A ; Knowlton, Robert C ; Szaflarski, Jerzy P ; Ver Hoef, Lawrence W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-d63db302d0e9a4eff991052f105bf2710048df6577be6f8fc0efe399909c14bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Anisotropy</topic><topic>Brain - pathology</topic><topic>Diffusion Tensor Imaging</topic><topic>Diffusion tensor imaging (DTI)</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Psychogenic non-epileptic seizures (PNES)</topic><topic>Psychophysiologic Disorders - pathology</topic><topic>Seizures - pathology</topic><topic>Superior temporal gyrus (STG)</topic><topic>Tract-based spatial statistics (TBSS)</topic><topic>Uncinate fasciculus (UF)</topic><topic>White Matter - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seongtaek</creatorcontrib><creatorcontrib>Allendorfer, Jane B</creatorcontrib><creatorcontrib>Gaston, Tyler E</creatorcontrib><creatorcontrib>Griffis, Joseph C</creatorcontrib><creatorcontrib>Hernando, Kathleen A</creatorcontrib><creatorcontrib>Knowlton, Robert C</creatorcontrib><creatorcontrib>Szaflarski, Jerzy P</creatorcontrib><creatorcontrib>Ver Hoef, Lawrence W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seongtaek</au><au>Allendorfer, Jane B</au><au>Gaston, Tyler E</au><au>Griffis, Joseph C</au><au>Hernando, Kathleen A</au><au>Knowlton, Robert C</au><au>Szaflarski, Jerzy P</au><au>Ver Hoef, Lawrence W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2015-09-16</date><risdate>2015</risdate><volume>1620</volume><spage>169</spage><epage>176</epage><pages>169-176</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Abstract The purpose of this study was to conduct a preliminary investigation of the white matter characteristics in patients with psychogenic non-epileptic seizures (PNES). Diffusion Tensor Imaging (DTI) data were collected at 3 T in 16 patients with PNES and 16 age- and sex-matched healthy controls (HC). All patients with PNES had their diagnosis confirmed via video/EEG monitoring; HCs had no comorbid neurological or psychiatric conditions. DTI indices including fractional anisotropy (FA), and mean diffusivity (MD) were calculated and compared between patients with PNES and HCs using Tract-Based Spatial Statistics (TBSS). Significantly higher FA values were observed in patients with PNES in the left corona radiata, left internal and external capsules, left superior temporal gyrus, as well as left uncinate fasciculus (UF) ( P <0.05; corrected for multiple comparisons). There was no significant change in other indices between patients with PNES and HCs. These findings suggest that patients with PNES have significantly altered white matter structural connectivity when compared to age- and sex-matched HCs. These abnormalities are present in left hemispheric regions associated with emotion regulation and motor pathways. While the relationship between the pathophysiology of PNES and these abnormalities is not entirely clear, this work provides an initial basis to guide future prospective studies.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25979311</pmid><doi>10.1016/j.brainres.2015.04.050</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8954-6103</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2015-09, Vol.1620, p.169-176 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1712768404 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Anisotropy Brain - pathology Diffusion Tensor Imaging Diffusion tensor imaging (DTI) Female Humans Male Middle Aged Neurology Psychogenic non-epileptic seizures (PNES) Psychophysiologic Disorders - pathology Seizures - pathology Superior temporal gyrus (STG) Tract-based spatial statistics (TBSS) Uncinate fasciculus (UF) White Matter - pathology Young Adult |
| title | White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T05%3A18%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=White%20matter%20diffusion%20abnormalities%20in%20patients%20with%20psychogenic%20non-epileptic%20seizures&rft.jtitle=Brain%20research&rft.au=Lee,%20Seongtaek&rft.date=2015-09-16&rft.volume=1620&rft.spage=169&rft.epage=176&rft.pages=169-176&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/j.brainres.2015.04.050&rft_dat=%3Cproquest_cross%3E1712768404%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1706575704&rft_id=info:pmid/25979311&rft_els_id=S0006899315003534&rfr_iscdi=true |