Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish

Small fish models have been used for decades in carcinogenicity testing. Demonstration of common morphological changes associated with specific mechanisms is a clear avenue by which data can be compared across divergent phyletic levels. Dimethylnitrosamine, used in rats to model human alcoholic cirr...

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Veröffentlicht in:	Veterinary pathology 2012-03, Vol.49 (2), p.372-385
Hauptverfasser:	Hobbie, K. R., DeAngelo, A. B., George, M. H., Law, J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biliary Tract Neoplasms - chemically induced Biliary Tract Neoplasms - pathology Biliary Tract Neoplasms - veterinary Biomarkers - metabolism Carcinogenicity Tests Carcinogens - toxicity Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - veterinary Cell Proliferation - drug effects Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - veterinary Dimethylnitrosamine - toxicity Disease Models, Animal Dose-Response Relationship, Drug Female Fish Diseases - chemically induced Fish Diseases - pathology Liver - drug effects Liver Neoplasms - chemically induced Liver Neoplasms - pathology Liver Neoplasms - veterinary Male Mutagenicity Tests Oryzias Oryzias latipes Rats Signal Transduction Species Specificity Transforming Growth Factor beta - metabolism
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