Single and Combination Toxic Metal Exposures Induce Apoptosis in Cultured Murine Podocytes Exclusively via the Extrinsic Caspase 8 Pathway

Arsenite, cadmium, and mercury are among the most abundant toxic metals (TM) in the environment. Although the most common renal manifestation of TM toxicity is proximal tubular dysfunction, significant glomerular injury can also occur. We hypothesized that glomerular injury following TM exposure res...

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Veröffentlicht in:	Toxicological sciences 2006-04, Vol.90 (2), p.392-399
Hauptverfasser:	Eichler, Tad, Ma, Qing, Kelly, Caitlin, Mishra, Jaya, Parikh, Samir, Ransom, Richard F., Devarajan, Prasad, Smoyer, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis Animals Apoptosis apoptotic pathway arsenite Arsenites - toxicity cadmium Cadmium - toxicity Caspase 8 Caspase 9 Caspases - metabolism Cell Line DNA Fragmentation Drug Interactions fas Receptor Fas-Associated Death Domain Protein In Situ Nick-End Labeling mercury Mercury - toxicity Mice Podocytes - drug effects Podocytes - metabolism Receptors, Tumor Necrosis Factor - biosynthesis
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