Towards allele-level human leucocyte antigens genotyping - assessing two next-generation sequencing platforms: Ion Torrent Personal Genome Machine and Illumina MiSeq

Summary Human leucocyte antigens (HLA) typing has been a challenge due to extreme polymorphism of the HLA genes and limitations of the current technologies and protocols used for their characterization. Recently, next‐generation sequencing techniques have been shown to be a well‐suited technology fo...

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Veröffentlicht in:	International journal of immunogenetics 2015-10, Vol.42 (5), p.346-358
Hauptverfasser:	Duke, J. L., Lind, C., Mackiewicz, K., Ferriola, D., Papazoglou, A., Derbeneva, O., Wallace, D., Monos, D. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Cell Line Genetic Loci Genome, Human Genotyping Techniques - methods High-Throughput Nucleotide Sequencing - methods HLA Antigens - genetics Homozygote Humans Sequence Alignment
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