Expression profiles of DNA repair-related genes in rat target organs under subchronic cadmium exposure

We aimed to evaluate the toxicity of long-term exposure to different cadmium (Cd) doses in rats and expression profiles of DNA repair-related genes. The model rats were exposed to different concentrations of CdCl2 for 3 months, and 5 DNA repair-related genes - hMSH2, MLH1, XRCC1, hOGG1, ERCC1 - were...

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Veröffentlicht in:	Genetics and molecular research 2015-01, Vol.14 (1), p.515-524
Hauptverfasser:	Lei, Y X, Lu, Q, Shao, C, He, C C, Lei, Z N, Lian, Y Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cadmium - toxicity DNA Methylation - drug effects DNA Methylation - genetics DNA Repair - drug effects DNA Repair - genetics Gene Expression Profiling Gene Expression Regulation - drug effects Organ Specificity - drug effects Organ Specificity - genetics Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Sequence Analysis, DNA
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