Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors

The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections...

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Veröffentlicht in:	Genetics and molecular research 2015-03, Vol.14 (1), p.2133-2138
Hauptverfasser:	Ren, B X, Ji, Y, Tang, J C, Sun, D P, Hui, X, Yang, D Q, Zhu, X L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Diterpenes, Abietane - administration & dosage Hyperalgesia - drug therapy Hyperalgesia - etiology Hyperalgesia - metabolism Injections, Spinal Interleukins - biosynthesis Male Mice Mice, Inbred C3H Myelitis - drug therapy Myelitis - metabolism Myelitis - pathology Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology Pain - drug therapy Pain - metabolism Tumor Necrosis Factor-alpha - biosynthesis
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