Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota
Necrotizing enterocolitis (NEC) remains one of the most frequent gastrointestinal diseases in the neonatal intensive care unit, with a continuing unacceptable high mortality and morbidity rates. Up to 20% to 40% of infants with NEC will need surgical intervention at some point. Although the exact pa...
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| Veröffentlicht in: | Inflammatory bowel diseases 2015-02, Vol.21 (2), p.436-444 |
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| container_title | Inflammatory bowel diseases |
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| creator | Niemarkt, Hendrik J de Meij, Tim G J van de Velde, Mirjam E van der Schee, Marc P van Goudoever, Johannes B Kramer, Boris W Andriessen, Peter de Boer, Nanne K H |
| description | Necrotizing enterocolitis (NEC) remains one of the most frequent gastrointestinal diseases in the neonatal intensive care unit, with a continuing unacceptable high mortality and morbidity rates. Up to 20% to 40% of infants with NEC will need surgical intervention at some point. Although the exact pathophysiology is not yet elucidated, prematurity, use of formula feeding, and an altered intestinal microbiota are supposed to induce an inflammatory response of the immature intestine. The clinical picture of NEC has been well described. However, an early diagnosis and differentiation against sepsis is challenging. Besides, it is difficult to timely identify NEC cases that will deteriorate and need surgical intervention. This may interfere with the most optimal treatment of infants with NEC. In this review, we discuss the pathogenesis, diagnosis, and treatment of NEC with a focus on the role of microbiota in the development of NEC. An overview of different clinical prediction models and biomarkers is given. Some of these are promising tools for accurate diagnosis of NEC and selection of appropriate therapy. |
| doi_str_mv | 10.1097/MIB.0000000000000184 |
| format | Article |
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Some of these are promising tools for accurate diagnosis of NEC and selection of appropriate therapy.</description><subject>Biomarkers - analysis</subject><subject>Enterocolitis, Necrotizing - diagnosis</subject><subject>Enterocolitis, Necrotizing - microbiology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intestines - microbiology</subject><subject>Microbiota</subject><subject>Risk Factors</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkclOwzAQhi0EomV5A4R85JLiPTE3qFgqFbjAOXKcaTEkcbFTEDw9hhaEuGAfPBp9_yz-ETqgZESJzo-vJ2cj8vvQQmygIZVcZaIQYjPFJC8yonUxQDsxPhLC0tXbaMAkU4Xiaoj8Ddjge_fuujmGrofgrW9c7-IJNtg2rnPWNDjAi4NX7DtcOzPvfOydxZXzrQlPECI2XY37B8DBN4D97Ct2qVriuiRvXWqS8N7soa2ZaSLsr99ddH9xfje-yqa3l5Px6TSzXJA-g1pykDYHozUhFSeWUU2VULSylGklLJe1AaCEW6NTTmvGKllRWmjFZMV30dGq7iL452Wao2xdtNA0pgO_jCXNKZM5p4L9jyrJBNOS5QkVKzStE2OAWbkILv3BW0lJ-elKmVwp_7qSZIfrDsuqhfpH9G0D_wC944hb</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Niemarkt, Hendrik J</creator><creator>de Meij, Tim G J</creator><creator>van de Velde, Mirjam E</creator><creator>van der Schee, Marc P</creator><creator>van Goudoever, Johannes B</creator><creator>Kramer, Boris W</creator><creator>Andriessen, Peter</creator><creator>de Boer, Nanne K H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150201</creationdate><title>Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota</title><author>Niemarkt, Hendrik J ; de Meij, Tim G J ; van de Velde, Mirjam E ; van der Schee, Marc P ; van Goudoever, Johannes B ; Kramer, Boris W ; Andriessen, Peter ; de Boer, Nanne K H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-ed53e5c7ea9900b30c21916461bc12964c35daee103ca9bc19922b5b1189625b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biomarkers - analysis</topic><topic>Enterocolitis, Necrotizing - diagnosis</topic><topic>Enterocolitis, Necrotizing - microbiology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intestines - microbiology</topic><topic>Microbiota</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niemarkt, Hendrik J</creatorcontrib><creatorcontrib>de Meij, Tim G J</creatorcontrib><creatorcontrib>van de Velde, Mirjam E</creatorcontrib><creatorcontrib>van der Schee, Marc P</creatorcontrib><creatorcontrib>van Goudoever, Johannes B</creatorcontrib><creatorcontrib>Kramer, Boris W</creatorcontrib><creatorcontrib>Andriessen, Peter</creatorcontrib><creatorcontrib>de Boer, Nanne K H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niemarkt, Hendrik J</au><au>de Meij, Tim G J</au><au>van de Velde, Mirjam E</au><au>van der Schee, Marc P</au><au>van Goudoever, Johannes B</au><au>Kramer, Boris W</au><au>Andriessen, Peter</au><au>de Boer, Nanne K H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>21</volume><issue>2</issue><spage>436</spage><epage>444</epage><pages>436-444</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Necrotizing enterocolitis (NEC) remains one of the most frequent gastrointestinal diseases in the neonatal intensive care unit, with a continuing unacceptable high mortality and morbidity rates. 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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Journals@Ovid Complete |
| subjects | Biomarkers - analysis Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - microbiology Humans Infant, Newborn Intestines - microbiology Microbiota Risk Factors |
| title | Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota |
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