Cationic polymer-based micro-emulgel with self-preserving ability for transdermal delivery of diclofenac sodium
The objective of the present study was to develop a topical preparation with enhanced skin permeation, high safety and self-preserving ability. Microemulsion (ME) and cationic polymer based micro-emulgel (CPBM) were investigated for the transdermal delivery of diclofenac sodium (DS). Medium-chain tr...
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| Veröffentlicht in: | Drug delivery 2015-08, Vol.22 (6), p.814-822 |
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| creator | Yang, Chunyu Shen, Yan Wang, Jue Ouahab, Ammar Zhang, Tao Tu, Jiasheng |
| description | The objective of the present study was to develop a topical preparation with enhanced skin permeation, high safety and self-preserving ability. Microemulsion (ME) and cationic polymer based micro-emulgel (CPBM) were investigated for the transdermal delivery of diclofenac sodium (DS). Medium-chain triglyceride was selected as the oil phase of ME due to its good solubilization of DS and high safety. Orthogonal test was applied to optimize the formula of ME based on the cumulative skin permeation amount in vitro after preliminary formula test. Chitosan (CS) or polylysine was employed as the cationic polymer in the formula of CPBM. The transdermal delivery of DS was evaluated through in vitro skin permeation test. The results showed that the skin permeation rate of DS from the optimized CPBM (126.17 ± 15.82 μg/cm
2
/h) were 1.86-folds and 5.76-folds higher than that of DS commercial Emulgel and DS control hydrogel, respectively. MEs and the cationic polymer were found to have skin penetration co-enhancing effect when they were combined in the CPBM system. Furthermore, the CPBM showed a good growth inhibition of E. coli and S. aureus. The stability test revealed that the CPBM was stable at room temperature and 4 °C for a period of three months. |
| doi_str_mv | 10.3109/10717544.2014.898111 |
| format | Article |
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2
/h) were 1.86-folds and 5.76-folds higher than that of DS commercial Emulgel and DS control hydrogel, respectively. MEs and the cationic polymer were found to have skin penetration co-enhancing effect when they were combined in the CPBM system. Furthermore, the CPBM showed a good growth inhibition of E. coli and S. aureus. The stability test revealed that the CPBM was stable at room temperature and 4 °C for a period of three months.</description><identifier>ISSN: 1071-7544</identifier><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.3109/10717544.2014.898111</identifier><identifier>PMID: 24724988</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Acrylic Resins - chemistry ; Administration, Cutaneous ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Cationic polymer ; Cations ; Chemistry, Pharmaceutical ; Chitosan - chemistry ; Chromatography, High Pressure Liquid ; Diclofenac - administration & dosage ; Diclofenac - pharmacokinetics ; diclofenac sodium ; Drug Delivery Systems - methods ; Emulsions - chemistry ; Escherichia coli - drug effects ; Gels - chemistry ; Hydrogen-Ion Concentration ; microemulgel ; Microscopy, Electron, Transmission ; Polylysine - chemistry ; self-preserving ; Skin Absorption ; Staphylococcus aureus - drug effects ; topical administration ; Triglycerides - chemistry ; Viscosity</subject><ispartof>Drug delivery, 2015-08, Vol.22 (6), p.814-822</ispartof><rights>2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-830131902941e80c2ee6c4bc171fa572ecba41d3f094b233da8ddef08df958e83</citedby><cites>FETCH-LOGICAL-c409t-830131902941e80c2ee6c4bc171fa572ecba41d3f094b233da8ddef08df958e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24724988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Chunyu</creatorcontrib><creatorcontrib>Shen, Yan</creatorcontrib><creatorcontrib>Wang, Jue</creatorcontrib><creatorcontrib>Ouahab, Ammar</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Tu, Jiasheng</creatorcontrib><title>Cationic polymer-based micro-emulgel with self-preserving ability for transdermal delivery of diclofenac sodium</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>The objective of the present study was to develop a topical preparation with enhanced skin permeation, high safety and self-preserving ability. Microemulsion (ME) and cationic polymer based micro-emulgel (CPBM) were investigated for the transdermal delivery of diclofenac sodium (DS). Medium-chain triglyceride was selected as the oil phase of ME due to its good solubilization of DS and high safety. Orthogonal test was applied to optimize the formula of ME based on the cumulative skin permeation amount in vitro after preliminary formula test. Chitosan (CS) or polylysine was employed as the cationic polymer in the formula of CPBM. The transdermal delivery of DS was evaluated through in vitro skin permeation test. The results showed that the skin permeation rate of DS from the optimized CPBM (126.17 ± 15.82 μg/cm
2
/h) were 1.86-folds and 5.76-folds higher than that of DS commercial Emulgel and DS control hydrogel, respectively. MEs and the cationic polymer were found to have skin penetration co-enhancing effect when they were combined in the CPBM system. Furthermore, the CPBM showed a good growth inhibition of E. coli and S. aureus. The stability test revealed that the CPBM was stable at room temperature and 4 °C for a period of three months.</description><subject>Acrylic Resins - chemistry</subject><subject>Administration, Cutaneous</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>Cationic polymer</subject><subject>Cations</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chitosan - chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Diclofenac - administration & dosage</subject><subject>Diclofenac - pharmacokinetics</subject><subject>diclofenac sodium</subject><subject>Drug Delivery Systems - methods</subject><subject>Emulsions - chemistry</subject><subject>Escherichia coli - drug effects</subject><subject>Gels - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>microemulgel</subject><subject>Microscopy, Electron, Transmission</subject><subject>Polylysine - chemistry</subject><subject>self-preserving</subject><subject>Skin Absorption</subject><subject>Staphylococcus aureus - drug effects</subject><subject>topical administration</subject><subject>Triglycerides - chemistry</subject><subject>Viscosity</subject><issn>1071-7544</issn><issn>1521-0464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1ERUvbf4CQj1yyeBynsU8IrcqHVIlLOVuOPS5GdrzYSav8e7zaliOnmcPzvqN5CHkHbNcDUx-BjTAOQuw4A7GTSgLAK3IBA4eOiRvxuu0N6Y7MOXlb62_GmAQ-vCHnXIxcKCkvSN6bJeQ5WHrIcUtYuslUdDQFW3KHaY0PGOlTWH7RitF3h4IVy2OYH6iZQgzLRn0udClmrg5LMpE6jOERy0azpy7YmD3OxtKaXVjTFTnzJla8fp6X5OeX2_v9t-7ux9fv-893nRVMLZ3sGfSgGFcCUDLLEW-smCyM4M0wcrSTEeB6z5SYeN87I51Dz6TzapAo-0vy4dR7KPnPinXRKVSLMZoZ81p1K-IDF71QDRUntH1ca0GvDyUkUzYNTB9V6xfV-qhan1S32PvnC-uU0P0LvbhtwKcTEOamKJmnXKLTi9liLr75sqEe6_9z4i-D6I97</recordid><startdate>20150818</startdate><enddate>20150818</enddate><creator>Yang, Chunyu</creator><creator>Shen, Yan</creator><creator>Wang, Jue</creator><creator>Ouahab, Ammar</creator><creator>Zhang, Tao</creator><creator>Tu, Jiasheng</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150818</creationdate><title>Cationic polymer-based micro-emulgel with self-preserving ability for transdermal delivery of diclofenac sodium</title><author>Yang, Chunyu ; Shen, Yan ; Wang, Jue ; Ouahab, Ammar ; Zhang, Tao ; Tu, Jiasheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-830131902941e80c2ee6c4bc171fa572ecba41d3f094b233da8ddef08df958e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acrylic Resins - chemistry</topic><topic>Administration, Cutaneous</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>Cationic polymer</topic><topic>Cations</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chitosan - chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Diclofenac - administration & dosage</topic><topic>Diclofenac - pharmacokinetics</topic><topic>diclofenac sodium</topic><topic>Drug Delivery Systems - methods</topic><topic>Emulsions - chemistry</topic><topic>Escherichia coli - drug effects</topic><topic>Gels - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>microemulgel</topic><topic>Microscopy, Electron, Transmission</topic><topic>Polylysine - chemistry</topic><topic>self-preserving</topic><topic>Skin Absorption</topic><topic>Staphylococcus aureus - drug effects</topic><topic>topical administration</topic><topic>Triglycerides - chemistry</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Chunyu</creatorcontrib><creatorcontrib>Shen, Yan</creatorcontrib><creatorcontrib>Wang, Jue</creatorcontrib><creatorcontrib>Ouahab, Ammar</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Tu, Jiasheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug delivery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Chunyu</au><au>Shen, Yan</au><au>Wang, Jue</au><au>Ouahab, Ammar</au><au>Zhang, Tao</au><au>Tu, Jiasheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cationic polymer-based micro-emulgel with self-preserving ability for transdermal delivery of diclofenac sodium</atitle><jtitle>Drug delivery</jtitle><addtitle>Drug Deliv</addtitle><date>2015-08-18</date><risdate>2015</risdate><volume>22</volume><issue>6</issue><spage>814</spage><epage>822</epage><pages>814-822</pages><issn>1071-7544</issn><eissn>1521-0464</eissn><abstract>The objective of the present study was to develop a topical preparation with enhanced skin permeation, high safety and self-preserving ability. Microemulsion (ME) and cationic polymer based micro-emulgel (CPBM) were investigated for the transdermal delivery of diclofenac sodium (DS). Medium-chain triglyceride was selected as the oil phase of ME due to its good solubilization of DS and high safety. Orthogonal test was applied to optimize the formula of ME based on the cumulative skin permeation amount in vitro after preliminary formula test. Chitosan (CS) or polylysine was employed as the cationic polymer in the formula of CPBM. The transdermal delivery of DS was evaluated through in vitro skin permeation test. The results showed that the skin permeation rate of DS from the optimized CPBM (126.17 ± 15.82 μg/cm
2
/h) were 1.86-folds and 5.76-folds higher than that of DS commercial Emulgel and DS control hydrogel, respectively. MEs and the cationic polymer were found to have skin penetration co-enhancing effect when they were combined in the CPBM system. Furthermore, the CPBM showed a good growth inhibition of E. coli and S. aureus. The stability test revealed that the CPBM was stable at room temperature and 4 °C for a period of three months.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>24724988</pmid><doi>10.3109/10717544.2014.898111</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acrylic Resins - chemistry Administration, Cutaneous Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Cationic polymer Cations Chemistry, Pharmaceutical Chitosan - chemistry Chromatography, High Pressure Liquid Diclofenac - administration & dosage Diclofenac - pharmacokinetics diclofenac sodium Drug Delivery Systems - methods Emulsions - chemistry Escherichia coli - drug effects Gels - chemistry Hydrogen-Ion Concentration microemulgel Microscopy, Electron, Transmission Polylysine - chemistry self-preserving Skin Absorption Staphylococcus aureus - drug effects topical administration Triglycerides - chemistry Viscosity |
| title | Cationic polymer-based micro-emulgel with self-preserving ability for transdermal delivery of diclofenac sodium |
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