KCa1.1 is potential marker for distinguishing Ah-type baroreceptor neurons in NTS and contributes to sex-specific presynaptic neurotransmission in baroreflex afferent pathway

•KCa1.1 mediates the afferent-specific neurotransmission in NTS in both male and female rats.•Increased glutamate release is seen in C- not A-type afferents by blocking KCa1.1 in male rats.•∼50% capsaicin-insensitive afferents are myelinated Ah-type BRNs in NTS in female rats.•C-like KCa1.1-mediated...

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Veröffentlicht in:	Neuroscience letters 2015-09, Vol.604, p.1-6
Hauptverfasser:	Zhang, Yu-Yao, Yan, Zhen-Yu, Qu, Mei-Yu, Guo, Xin-Jing, Li, Guo, Lu, Xiao-Long, Liu, Yang, Ban, Tao, Sun, Hong-Li, Qiao, Guo-Fen, Li, Bai-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways Animals Aorta - innervation Baroreflex Brain Stem - physiology Capsaicin - pharmacology Electric Stimulation Excitatory post-synaptic current (EPSC) Excitatory Postsynaptic Potentials Female Gender difference Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - physiology Male Nerve Fibers, Myelinated - physiology Nerve Fibers, Unmyelinated - physiology Neurons - physiology Nucleus tractus solitary (NTS) Peptides - pharmacology Pressoreceptors - metabolism Rats, Sprague-Dawley Sex Factors Solitary Nucleus - physiology Synapses - physiology Synaptic Transmission Visceral afferent
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