Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix

Although caspase activity in the nervous system of mollusks has not been described before, we suggested that these cysteine proteases might be involved in the phenomena of neuroplasticity in mollusks. We directly measured caspase‐3 (DEVDase) activity in the Helix lucorum central nervous system (CNS)...

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Veröffentlicht in:	The European journal of neuroscience 2006-01, Vol.23 (1), p.129-140
Hauptverfasser:	Bravarenko, N. I., Onufriev, M. V., Stepanichev, M. Yu, Ierusalimsky, V. N., Balaban, P. M., Gulyaeva, N. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blotting, Western - methods caspase Caspase 3 Caspases - metabolism Caspases - pharmacology Central Nervous System - cytology Central Nervous System - physiology Drug Interactions Enzyme Inhibitors - pharmacology Gene Expression - drug effects Helix Helix (Snails) Helix lucorum Immunohistochemistry - methods In Situ Nick-End Labeling - methods In Vitro Techniques long-term synaptic plasticity Mollusca Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neuronal Plasticity - radiation effects Neurons - classification Neurons - cytology Neurons - physiology Oligopeptides - pharmacology snail Staurosporine - pharmacology Synapses - drug effects Synapses - physiology Synapses - radiation effects
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