Metallothionein and Anti-Metallothionein, Complementary Elements of Cadmium-Induced Renal Disease
Metallothionein (MT) is a lowmolecular weight, cysteine-rich stress response protein with a high affinity for divalent heavy metals. MT was originally identified as a cadmium-rich protein in the equine renal cortex. A large amount of subsequent work has shown MT to serve in many cell types in the ma...
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| Veröffentlicht in: | Toxicological sciences 2006-05, Vol.91 (1), p.1-3 |
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| creator | Lynes, Michael A. Yin, Xiuyun |
| description | Metallothionein (MT) is a lowmolecular weight, cysteine-rich stress response protein with a high affinity for divalent heavy metals. MT was originally identified as a cadmium-rich protein in the equine renal cortex. A large amount of subsequent work has shown MT to serve in many cell types in the management of essential divalent metal cations, to interfere with the toxic effects of xenobiotics, heavy metals, and free radicals, and to serve as a regulator of specific transcription factors. As a consequence of these various activities, MT synthesis has an impact on developmental processes and on the cellular responses to stressful conditions. MT is primarily synthesized on free polysomes. Based on these observations, MT has often been considered to function exclusively as an intracellular protein |
| doi_str_mv | 10.1093/toxsci/kfj149 |
| format | Article |
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Based on these observations, MT has often been considered to function exclusively as an intracellular protein</description><subject>Antigen-Antibody Complex</subject><subject>Autoantibodies - immunology</subject><subject>cadmium</subject><subject>Cadmium - toxicity</subject><subject>Humans</subject><subject>immune complex</subject><subject>inflammation</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - immunology</subject><subject>Kidney Diseases - physiopathology</subject><subject>metallothionein</subject><subject>Metallothionein - immunology</subject><subject>Metallothionein - physiology</subject><subject>nephropathy</subject><issn>1096-6080</issn><issn>1096-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1Lw0AQxRdRbK0evUpOnoydzcc2e6z9sNKKoBWkl2WzO8Ft81GzCdT_3kiCBU_zmPebB_MIuaZwT4H7w6o4WGWGu2RLA35C-s2SucA9ftppBhH0yIW1WwBKGfBz0qOMRRDRoE_kM1YyTYvq0xQ5mtyRuXbGeWXcf8adMymyfYoZ5pUsv51ZK61TJM5E6szUmfuU61qhdl4xl6kzNRalxUtylsjU4lU3B-R9PltPFu7q5fFpMl65yue8clkIGEpJA6U9xcHTMQtozLwAJAu0BPRQ-yGjXEXggcKRVAoZjYPmLqKg_QG5bXP3ZfFVo61EZqzCNJU5FrUVdEQ96jHegG4LqrKwtsRE7EuTNT8JCuK3U9F2KtpOG_6mC67jDPWR7ko8Bhpb4eHPl-VOsJE_CsXiYyMeNm_r5XwaiqX_A9_LhR0</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Lynes, Michael A.</creator><creator>Yin, Xiuyun</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200605</creationdate><title>Metallothionein and Anti-Metallothionein, Complementary Elements of Cadmium-Induced Renal Disease</title><author>Lynes, Michael A. ; Yin, Xiuyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-650e5aa14cd2c902db641b6240a64da0e2ed35619c8020ce7acce61b450e810d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antigen-Antibody Complex</topic><topic>Autoantibodies - immunology</topic><topic>cadmium</topic><topic>Cadmium - toxicity</topic><topic>Humans</topic><topic>immune complex</topic><topic>inflammation</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - immunology</topic><topic>Kidney Diseases - physiopathology</topic><topic>metallothionein</topic><topic>Metallothionein - immunology</topic><topic>Metallothionein - physiology</topic><topic>nephropathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynes, Michael A.</creatorcontrib><creatorcontrib>Yin, Xiuyun</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynes, Michael A.</au><au>Yin, Xiuyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metallothionein and Anti-Metallothionein, Complementary Elements of Cadmium-Induced Renal Disease</atitle><jtitle>Toxicological sciences</jtitle><addtitle>Toxicol. Sci</addtitle><date>2006-05</date><risdate>2006</risdate><volume>91</volume><issue>1</issue><spage>1</spage><epage>3</epage><pages>1-3</pages><issn>1096-6080</issn><eissn>1096-0929</eissn><abstract>Metallothionein (MT) is a lowmolecular weight, cysteine-rich stress response protein with a high affinity for divalent heavy metals. MT was originally identified as a cadmium-rich protein in the equine renal cortex. A large amount of subsequent work has shown MT to serve in many cell types in the management of essential divalent metal cations, to interfere with the toxic effects of xenobiotics, heavy metals, and free radicals, and to serve as a regulator of specific transcription factors. As a consequence of these various activities, MT synthesis has an impact on developmental processes and on the cellular responses to stressful conditions. MT is primarily synthesized on free polysomes. 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| ispartof | Toxicological sciences, 2006-05, Vol.91 (1), p.1-3 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Antigen-Antibody Complex Autoantibodies - immunology cadmium Cadmium - toxicity Humans immune complex inflammation Kidney Diseases - chemically induced Kidney Diseases - immunology Kidney Diseases - physiopathology metallothionein Metallothionein - immunology Metallothionein - physiology nephropathy |
| title | Metallothionein and Anti-Metallothionein, Complementary Elements of Cadmium-Induced Renal Disease |
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