Absence of systemic in vivo genotoxicity after dermal exposure to ethyl acrylate and tripropylene glycol diacrylate in Tg.AC (v-Ha-ras) mice

Acrylates may be polymerized to stable surface coatings (paints, lacquers, inks, etc.) by alkylation via the Michaelis‐type addition reaction. Thus, acrylates have an inherent potential as electrophiles to be genotoxic, limited in their biological activity by their physicochemical properties. To eva...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1997, Vol.29 (3), p.240-249
Hauptverfasser:	Tice, R. R., Nylander-French, L. A., French, J. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - administration & dosage Acrylates - toxicity Administration, Topical alkaline single cell gel electrophoresis Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases DNA Damage Erythrocytes, Abnormal Female genotoxicity Medical sciences Mice Mice, Transgenic micronuclei Micronucleus Tests monofunctional acrylates multifunctional acrylates Propylene Glycols - administration & dosage Propylene Glycols - toxicity skin Toxicology transgenic mouse Various organic compounds
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