Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

1H NMR spectroscopy of urine combined with pattern recognition (PR) methods of data analysis has been used to investigate the time-related biochemical changes induced in Sprague−Dawley rats by three model hepatotoxins:  α-naphthyl isothiocyanate (ANIT), d-(+)-galactosamine (GalN), and butylated hydr...

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Veröffentlicht in:	Chemical research in toxicology 1998-04, Vol.11 (4), p.260-272
Hauptverfasser:	Beckwith-Hall, B. M, Nicholson, J. K, Nicholls, A. W, Foxall, P. J. D, Lindon, J. C, Connor, S. C, Abdi, M, Connelly, J, Holmes, E
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylisothiocyanate - chemistry 1-Naphthylisothiocyanate - toxicity Animals Butylated Hydroxytoluene - chemistry Butylated Hydroxytoluene - toxicity Galactosamine - chemistry Galactosamine - toxicity Liver - drug effects Liver - metabolism Liver - pathology Magnetic Resonance Spectroscopy Male Rats Structure-Activity Relationship
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