Relation of New Permanent Right or Left Bundle Branch Block on Short- and Long-Term Mortality in Acute Myocardial Infarction Bundle Branch Block and Myocardial Infarction

The aim of this study was to investigate the prognosis associated with bundle branch block (BBB) depending on location, time of appearance, and duration in patients with myocardial infarction (MI). From January 1998 to January 2008, we recruited 5,570 patients with acute MI. Thirty-day and 7-year al...

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Veröffentlicht in:The American journal of cardiology 2015-10, Vol.116 (7), p.1003-1009
Hauptverfasser: Melgarejo-Moreno, Antonio, MD, PhD, Galcerá-Tomás, José, MD, PhD, Consuegra-Sánchez, Luciano, MD, PhD, Alonso-Fernández, Nuria, MD, PhD, Díaz-Pastor, Ángela, MD, Escudero-García, Germán, MD, Jaulent-Huertas, Leticia, MD, Vicente-Gilabert, Marta, MD, Galcerá-Jornet, Emilio, MD, Padilla-Serrano, Antonio, MD, PhD, de Gea-García, José, MD, MD, Pinar-Bermudez, Eduardo, MD, PhD
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container_end_page 1009
container_issue 7
container_start_page 1003
container_title The American journal of cardiology
container_volume 116
creator Melgarejo-Moreno, Antonio, MD, PhD
Galcerá-Tomás, José, MD, PhD
Consuegra-Sánchez, Luciano, MD, PhD
Alonso-Fernández, Nuria, MD, PhD
Díaz-Pastor, Ángela, MD
Escudero-García, Germán, MD
Jaulent-Huertas, Leticia, MD
Vicente-Gilabert, Marta, MD
Galcerá-Jornet, Emilio, MD
Padilla-Serrano, Antonio, MD, PhD
de Gea-García, José, MD, MD
Pinar-Bermudez, Eduardo, MD, PhD
description The aim of this study was to investigate the prognosis associated with bundle branch block (BBB) depending on location, time of appearance, and duration in patients with myocardial infarction (MI). From January 1998 to January 2008, we recruited 5,570 patients with acute MI. Thirty-day and 7-year all-cause mortality, according to BBB location, time of appearance, and duration were analyzed by multivariable analyses. BBB was present in 964 patients (17.3%); right BBB (RBBB) 10.6% and left BBB (LBBB) 6.7%. Overall mortality rate at 30 days was 13.2% (n = 738) and 7 years was 6.34 deaths per 100 patient-year. Both RBBB and LBBB were more frequently previous, 42.9% and 58.8%. Compared with non-BBB, all BBB groups showed higher prevalence of co-morbidities, especially rates of diabetes (49.0% vs 34.3%, p
doi_str_mv 10.1016/j.amjcard.2015.07.019
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From January 1998 to January 2008, we recruited 5,570 patients with acute MI. Thirty-day and 7-year all-cause mortality, according to BBB location, time of appearance, and duration were analyzed by multivariable analyses. BBB was present in 964 patients (17.3%); right BBB (RBBB) 10.6% and left BBB (LBBB) 6.7%. Overall mortality rate at 30 days was 13.2% (n = 738) and 7 years was 6.34 deaths per 100 patient-year. Both RBBB and LBBB were more frequently previous, 42.9% and 58.8%. Compared with non-BBB, all BBB groups showed higher prevalence of co-morbidities, especially rates of diabetes (49.0% vs 34.3%, p &lt;0.001) and more often heart failure during hospitalization (54.5% vs 26.6%, p &lt;0.001). Compared with RBBB, patients with LBBB had a higher prevalence of co-morbidities and a higher mortality, especially the new BBB, 30 days: 52.5% versus 31.6% and 7 years (incident rate): 27.2 versus 13.3 per 100 patient-year. New transient BBB had lower heart failure on admission (42.6% vs 58.3%, p = 0.008) and 30-day mortality (20.3% vs 69.6%, p &lt;0.001) compared with permanent in both locations. New permanent RBBB was independently associated with 30-day (hazard ratio [HR] 2.01, 95% confidence interval [CI] 1.45 to 2.79) and 7-year mortality (HR 3.12, 95% CI 2.38 to 4.09). New-permanent LBBB was independently associated with 30-day (HR 2.15, 95% CI 1.47 to 3.15) and 7-year mortality (HR 2.91, 95% CI 2.08 to 4.08). In conclusion, in patients with acute MI, the appearance of a new BBB was independently associated with a higher 30-day and 7-year all-cause mortality.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2015.07.019</identifier><identifier>PMID: 26253998</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Blood pressure ; Bundle-Branch Block - etiology ; Bundle-Branch Block - mortality ; Bundle-Branch Block - physiopathology ; Cardiovascular ; Cause of Death - trends ; Chronic obstructive pulmonary disease ; Confidence intervals ; Diabetes ; Electrocardiography ; Female ; Follow-Up Studies ; Heart attacks ; Heart Conduction System - physiopathology ; Heart failure ; Heart rate ; Hospital Mortality - trends ; Hospitals ; Humans ; Hypertension ; Male ; Medical prognosis ; Middle Aged ; Mortality ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Myocardial Infarction - physiopathology ; Prognosis ; Prospective Studies ; Risk Assessment - methods ; Risk Factors ; Spain - epidemiology ; Stroke ; Survival Rate - trends ; Time Factors ; Variables</subject><ispartof>The American journal of cardiology, 2015-10, Vol.116 (7), p.1003-1009</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 1, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-797c27de7eadfa8d0eb0ef8bf92957dce6f60c9ad432dcd623d46eb5eb50ca333</citedby><cites>FETCH-LOGICAL-c448t-797c27de7eadfa8d0eb0ef8bf92957dce6f60c9ad432dcd623d46eb5eb50ca333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1710029821?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26253998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melgarejo-Moreno, Antonio, MD, PhD</creatorcontrib><creatorcontrib>Galcerá-Tomás, José, MD, PhD</creatorcontrib><creatorcontrib>Consuegra-Sánchez, Luciano, MD, PhD</creatorcontrib><creatorcontrib>Alonso-Fernández, Nuria, MD, PhD</creatorcontrib><creatorcontrib>Díaz-Pastor, Ángela, MD</creatorcontrib><creatorcontrib>Escudero-García, Germán, MD</creatorcontrib><creatorcontrib>Jaulent-Huertas, Leticia, MD</creatorcontrib><creatorcontrib>Vicente-Gilabert, Marta, MD</creatorcontrib><creatorcontrib>Galcerá-Jornet, Emilio, MD</creatorcontrib><creatorcontrib>Padilla-Serrano, Antonio, MD, PhD</creatorcontrib><creatorcontrib>de Gea-García, José, MD, MD</creatorcontrib><creatorcontrib>Pinar-Bermudez, Eduardo, MD, PhD</creatorcontrib><title>Relation of New Permanent Right or Left Bundle Branch Block on Short- and Long-Term Mortality in Acute Myocardial Infarction Bundle Branch Block and Myocardial Infarction</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The aim of this study was to investigate the prognosis associated with bundle branch block (BBB) depending on location, time of appearance, and duration in patients with myocardial infarction (MI). From January 1998 to January 2008, we recruited 5,570 patients with acute MI. Thirty-day and 7-year all-cause mortality, according to BBB location, time of appearance, and duration were analyzed by multivariable analyses. BBB was present in 964 patients (17.3%); right BBB (RBBB) 10.6% and left BBB (LBBB) 6.7%. Overall mortality rate at 30 days was 13.2% (n = 738) and 7 years was 6.34 deaths per 100 patient-year. Both RBBB and LBBB were more frequently previous, 42.9% and 58.8%. Compared with non-BBB, all BBB groups showed higher prevalence of co-morbidities, especially rates of diabetes (49.0% vs 34.3%, p &lt;0.001) and more often heart failure during hospitalization (54.5% vs 26.6%, p &lt;0.001). Compared with RBBB, patients with LBBB had a higher prevalence of co-morbidities and a higher mortality, especially the new BBB, 30 days: 52.5% versus 31.6% and 7 years (incident rate): 27.2 versus 13.3 per 100 patient-year. New transient BBB had lower heart failure on admission (42.6% vs 58.3%, p = 0.008) and 30-day mortality (20.3% vs 69.6%, p &lt;0.001) compared with permanent in both locations. New permanent RBBB was independently associated with 30-day (hazard ratio [HR] 2.01, 95% confidence interval [CI] 1.45 to 2.79) and 7-year mortality (HR 3.12, 95% CI 2.38 to 4.09). New-permanent LBBB was independently associated with 30-day (HR 2.15, 95% CI 1.47 to 3.15) and 7-year mortality (HR 2.91, 95% CI 2.08 to 4.08). In conclusion, in patients with acute MI, the appearance of a new BBB was independently associated with a higher 30-day and 7-year all-cause mortality.</description><subject>Aged</subject><subject>Blood pressure</subject><subject>Bundle-Branch Block - etiology</subject><subject>Bundle-Branch Block - mortality</subject><subject>Bundle-Branch Block - physiopathology</subject><subject>Cardiovascular</subject><subject>Cause of Death - trends</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart attacks</subject><subject>Heart Conduction System - physiopathology</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Hospital Mortality - trends</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Stroke</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><subject>Variables</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt9qFDEUxoModq0-ghLwxpsZk8zf3Cjd4p_CVqWt4F3IJme6mc4mbZJR9m36AD5Fn8yMu7pQBCEQEn7fd07OF4SeU5JTQuvXfS7XvZJe54zQKidNTih_gGa0bXhGOS0eohkhhGWclvwAPQmhT0dKq_oxOmA1qwrO2xn6eQaDjMZZ7Dr8CX7gL-DX0oKN-MxcriJ2Hi-gi3g-Wj0Anntp1QrPB6eucFKdr5yPGZZW44Wzl9lFkuPTdCcHEzfYWHykxgj4dOOmZo0c8IntpFe_a_7LNFnd3e7xu9s9_xQ96uQQ4NluP0Rf37-7OP6YLT5_ODk-WmSqLNuYNbxRrNHQgNSdbDWBJYGuXXac8arRCuquJopLXRZMK12zQpc1LKu0iJJFURyiV1vfa-9uRghRrE1QMAxpMG4MgjZpjmXdcpbQl_fQ3o3epu4mKs2ft4wmqtpSyrsQPHTi2pu19BtBiZjiFL3YxSmmOAVpRIoz6V7s3MflGvRf1Z_8EvB2C0Aax3cDXgRlwCrQxoOKQjvz3xJv7jmowVij5HAFGwj714jABBHn05-avhStkifj34pf_lfMNg</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Melgarejo-Moreno, Antonio, MD, PhD</creator><creator>Galcerá-Tomás, José, MD, PhD</creator><creator>Consuegra-Sánchez, Luciano, MD, PhD</creator><creator>Alonso-Fernández, Nuria, MD, PhD</creator><creator>Díaz-Pastor, Ángela, MD</creator><creator>Escudero-García, Germán, MD</creator><creator>Jaulent-Huertas, Leticia, MD</creator><creator>Vicente-Gilabert, Marta, MD</creator><creator>Galcerá-Jornet, Emilio, MD</creator><creator>Padilla-Serrano, Antonio, MD, PhD</creator><creator>de Gea-García, José, MD, MD</creator><creator>Pinar-Bermudez, Eduardo, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Relation of New Permanent Right or Left Bundle Branch Block on Short- and Long-Term Mortality in Acute Myocardial Infarction Bundle Branch Block and Myocardial Infarction</title><author>Melgarejo-Moreno, Antonio, MD, PhD ; Galcerá-Tomás, José, MD, PhD ; Consuegra-Sánchez, Luciano, MD, PhD ; Alonso-Fernández, Nuria, MD, PhD ; Díaz-Pastor, Ángela, MD ; Escudero-García, Germán, MD ; Jaulent-Huertas, Leticia, MD ; Vicente-Gilabert, Marta, MD ; Galcerá-Jornet, Emilio, MD ; Padilla-Serrano, Antonio, MD, PhD ; de Gea-García, José, MD, MD ; Pinar-Bermudez, Eduardo, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-797c27de7eadfa8d0eb0ef8bf92957dce6f60c9ad432dcd623d46eb5eb50ca333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Blood pressure</topic><topic>Bundle-Branch Block - etiology</topic><topic>Bundle-Branch Block - mortality</topic><topic>Bundle-Branch Block - physiopathology</topic><topic>Cardiovascular</topic><topic>Cause of Death - trends</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Confidence intervals</topic><topic>Diabetes</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart attacks</topic><topic>Heart Conduction System - physiopathology</topic><topic>Heart failure</topic><topic>Heart rate</topic><topic>Hospital Mortality - trends</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>Spain - epidemiology</topic><topic>Stroke</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melgarejo-Moreno, Antonio, MD, PhD</creatorcontrib><creatorcontrib>Galcerá-Tomás, José, MD, PhD</creatorcontrib><creatorcontrib>Consuegra-Sánchez, Luciano, MD, PhD</creatorcontrib><creatorcontrib>Alonso-Fernández, Nuria, MD, PhD</creatorcontrib><creatorcontrib>Díaz-Pastor, Ángela, MD</creatorcontrib><creatorcontrib>Escudero-García, Germán, MD</creatorcontrib><creatorcontrib>Jaulent-Huertas, Leticia, MD</creatorcontrib><creatorcontrib>Vicente-Gilabert, Marta, MD</creatorcontrib><creatorcontrib>Galcerá-Jornet, Emilio, MD</creatorcontrib><creatorcontrib>Padilla-Serrano, Antonio, MD, PhD</creatorcontrib><creatorcontrib>de Gea-García, José, MD, MD</creatorcontrib><creatorcontrib>Pinar-Bermudez, Eduardo, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; 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From January 1998 to January 2008, we recruited 5,570 patients with acute MI. Thirty-day and 7-year all-cause mortality, according to BBB location, time of appearance, and duration were analyzed by multivariable analyses. BBB was present in 964 patients (17.3%); right BBB (RBBB) 10.6% and left BBB (LBBB) 6.7%. Overall mortality rate at 30 days was 13.2% (n = 738) and 7 years was 6.34 deaths per 100 patient-year. Both RBBB and LBBB were more frequently previous, 42.9% and 58.8%. Compared with non-BBB, all BBB groups showed higher prevalence of co-morbidities, especially rates of diabetes (49.0% vs 34.3%, p &lt;0.001) and more often heart failure during hospitalization (54.5% vs 26.6%, p &lt;0.001). Compared with RBBB, patients with LBBB had a higher prevalence of co-morbidities and a higher mortality, especially the new BBB, 30 days: 52.5% versus 31.6% and 7 years (incident rate): 27.2 versus 13.3 per 100 patient-year. New transient BBB had lower heart failure on admission (42.6% vs 58.3%, p = 0.008) and 30-day mortality (20.3% vs 69.6%, p &lt;0.001) compared with permanent in both locations. New permanent RBBB was independently associated with 30-day (hazard ratio [HR] 2.01, 95% confidence interval [CI] 1.45 to 2.79) and 7-year mortality (HR 3.12, 95% CI 2.38 to 4.09). New-permanent LBBB was independently associated with 30-day (HR 2.15, 95% CI 1.47 to 3.15) and 7-year mortality (HR 2.91, 95% CI 2.08 to 4.08). In conclusion, in patients with acute MI, the appearance of a new BBB was independently associated with a higher 30-day and 7-year all-cause mortality.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26253998</pmid><doi>10.1016/j.amjcard.2015.07.019</doi><tpages>7</tpages></addata></record>
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source MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland
subjects Aged
Blood pressure
Bundle-Branch Block - etiology
Bundle-Branch Block - mortality
Bundle-Branch Block - physiopathology
Cardiovascular
Cause of Death - trends
Chronic obstructive pulmonary disease
Confidence intervals
Diabetes
Electrocardiography
Female
Follow-Up Studies
Heart attacks
Heart Conduction System - physiopathology
Heart failure
Heart rate
Hospital Mortality - trends
Hospitals
Humans
Hypertension
Male
Medical prognosis
Middle Aged
Mortality
Myocardial Infarction - complications
Myocardial Infarction - mortality
Myocardial Infarction - physiopathology
Prognosis
Prospective Studies
Risk Assessment - methods
Risk Factors
Spain - epidemiology
Stroke
Survival Rate - trends
Time Factors
Variables
title Relation of New Permanent Right or Left Bundle Branch Block on Short- and Long-Term Mortality in Acute Myocardial Infarction Bundle Branch Block and Myocardial Infarction
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