Regulation of brown fat by AMP-activated protein kinase

Highlights • Suppressing AMPK activity in the brain increases energy expenditure via brown fat. • Enhancing AMPK activity in brown adipocytes increases brown fat activity. • Targeting AMPK in brown fat holds therapeutic potential for the treatment of obesity.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in molecular medicine 2015-09, Vol.21 (9), p.571-579
Hauptverfasser:	van Dam, Andrea D, Kooijman, Sander, Schilperoort, Maaike, Rensen, Patrick C.N, Boon, Mariëtte R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - enzymology Adipose Tissue, Brown - metabolism AMP-activated protein kinase AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals brown adipose tissue energy expenditure Humans hypothalamus Obesity - enzymology Obesity - genetics Obesity - metabolism Obesity - physiopathology Pathology Thermogenesis uncoupling protein 1
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Beschreibung
Zusammenfassung:	Highlights • Suppressing AMPK activity in the brain increases energy expenditure via brown fat. • Enhancing AMPK activity in brown adipocytes increases brown fat activity. • Targeting AMPK in brown fat holds therapeutic potential for the treatment of obesity.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2015.07.003