Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid‑β Plaques in Alzheimer’s Disease

Alzheimer’s disease (AD) is pathologically characterized by the accumulation of β-amyloid (Aβ) deposits in the parenchymal and cortical brain. In this work, we designed, synthesized, and evaluated a series of near-infrared (NIR) probes with electron donor–acceptor end groups interacting through a π-...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-09, Vol.58 (17), p.6972-6983
Hauptverfasser:	Fu, Hualong, Cui, Mengchao, Zhao, Liu, Tu, Peiyu, Zhou, Kaixiang, Dai, Jiapei, Liu, Boli
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Naphthylamine - analogs & derivatives 2-Naphthylamine - chemical synthesis 2-Naphthylamine - chemistry 2-Naphthylamine - pharmacokinetics Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Animals Blood-Brain Barrier - metabolism Brain - metabolism Brain - pathology Female Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacokinetics Humans Male Mice, Inbred ICR Mice, Transgenic Middle Aged Molecular Docking Simulation Nitriles - chemical synthesis Nitriles - chemistry Nitriles - pharmacokinetics Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Protein Binding Spectroscopy, Near-Infrared Stereoisomerism
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