Effects of short RNA structural analogues against hepatitis C virus genotypes 2, 3 and 4 in replicon cells

Objective To determine whether computer‐predicted short RNA structural analogues could inhibit hepatitis C virus (HCV) genotype 2a, 3a and 4a replication in cultured cells. Methods Short RNA sequences, X12, X12a and X12b, designed to be identical in secondary structure to the X region in the 3′‐untr...

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Veröffentlicht in:	Journal of digestive diseases 2015-08, Vol.16 (8), p.449-455
Hauptverfasser:	Elshaffei, Ismail M, Gupta, Nidhi, Wu, Catherine H, Wu, David C, Hammad, Lamiaa N, Abo-Elmatty, Dina M, Mesbah, Noha M, Wu, George Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - virology cross inhibition Genes Genotype Genotype & phenotype Hepacivirus - genetics Hepacivirus - physiology Hepatitis hepatitis C virus Humans Liver Neoplasms - virology Luciferases - metabolism Molecular Mimicry Molecular Sequence Data replication Replicon - genetics RNA structural analogue RNA, Viral - genetics RNA, Viral - isolation & purification Transfection Tumor Cells, Cultured Virus Replication - genetics
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