Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

We have studied the apoptotic response of poly(ADP-ribose) polymerase (PARP)-/- cells to different inducers and the consequences of the expression of an uncleavable mutant of PARP on the apoptotic process. The absence of PARP drastically increases the sensitivity of primary bone marrow PARP-/- cells...

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Veröffentlicht in:	J Biol Chem 1998-12, Vol.273 (50), p.33533-33539
Hauptverfasser:	Oliver, F J, de la Rubia, G, Rolli, V, Ruiz-Ruiz, M C, de Murcia, G, Murcia, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents Alkylating Agents - pharmacology Animals Apoptosis Apoptosis - drug effects Biochemistry, Molecular Biology Cell Line, Transformed Cell Nucleus Cell Nucleus - enzymology Cell Nucleus - metabolism Cytoplasm Cytoplasm - enzymology Cytoplasm - metabolism fas Receptor fas Receptor - metabolism Hydrolysis Life Sciences Mice Mutagenesis, Site-Directed Poly(ADP-ribose) Polymerases Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Structural Biology
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