Endogenously Bound Calmodulin Is Essential for the Function of the Inositol 1,4,5-Trisphosphate Receptor

Calmodulin (CaM) is a ubiquitous Ca2+ sensor protein that plays an important role in regulating a large number of Ca2+ channels, including the inositol 1,4,5-trisphosphate receptor (IP3R). Despite many efforts, the exact mechanism by which CaM regulates the IP3R still remains elusive. Here we show,...

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Veröffentlicht in:	The Journal of biological chemistry 2006-03, Vol.281 (13), p.8332-8338
Hauptverfasser:	Kasri, Nael Nadif, Török, Katalin, Galione, Antony, Garnham, Clive, Callewaert, Geert, Missiaen, Ludwig, Parys, Jan B., De Smedt, Humbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Calcium - analysis Calcium - antagonists & inhibitors Calcium - metabolism Calcium Channels - genetics Calcium Channels - metabolism Calmodulin - metabolism Calmodulin - physiology Cell Line Chlorocebus aethiops COS Cells Dose-Response Relationship, Drug Female Fibroblasts - drug effects Fibroblasts - metabolism Humans Inositol 1,4,5-Trisphosphate Receptors Kinetics Lung - cytology Myosin-Light-Chain Kinase - chemistry Myosin-Light-Chain Kinase - pharmacology Oocytes - drug effects Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Sea Urchins - cytology Spodoptera - cytology Spodoptera - genetics
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