S100A9-induced release of interleukin (IL)-6 and IL-8 through toll-like receptor 4 (TLR4) in human periodontal ligament cells

•S100A9-induced release of IL-6 and IL-8 from PDL cells depends on TLR4.•S100A9 up-regulates the secretion of IL-6 through NF-κB and p38 pathways.•S100A9 up-regulates IL-8 through the NF-κB, ERK1/2, JNK and p38 pathways.•S100A9-mediated secretion of IL-6, IL-8 depends on ROS production. S100A8, S100...

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Veröffentlicht in:	Molecular immunology 2015-10, Vol.67 (2), p.223-232
Hauptverfasser:	Gao, Hongyu, Zhang, Xin, Zheng, Yunfei, Peng, Lei, Hou, Jianxia, Meng, Huanxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Calgranulin B - metabolism Female Gene Silencing - drug effects Humans Interleukin-6 - metabolism Interleukin-8 - metabolism Male MAP Kinase Signaling System - drug effects NF-kappa B - metabolism PDL cells Periodontal Ligament - cytology Phosphorylation - drug effects Pro-inflammatory effects Protein Kinase Inhibitors - pharmacology Reactive Oxygen Species - metabolism Receptor for Advanced Glycation End Products - metabolism S100A9 Time Factors Toll-Like Receptor 4 - metabolism Up-Regulation - drug effects Young Adult
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