The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy
Introduction: Malfunctioning of the cardiovascular system during pregnancy may be responsible for adverse effects on the ‘mother-fetus’ system. The cardiovascular system of a pregnant woman develops adaptation to the increased load. Angiotensin-converting enzyme (ACE) is known to play an important r...
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| Veröffentlicht in: | Journal of the renin-angiotensin-aldosterone system 2015-09, Vol.16 (3), p.623-632 |
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| container_title | Journal of the renin-angiotensin-aldosterone system |
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| creator | Reshetnikov, Evgeny A Akulova, Ludmila Y Dobrodomova, Irina S Dvornyk, Volodymyr Y Polonikov, Alexey V Churnosov, Mikhail I |
| description | Introduction:
Malfunctioning of the cardiovascular system during pregnancy may be responsible for adverse effects on the ‘mother-fetus’ system. The cardiovascular system of a pregnant woman develops adaptation to the increased load. Angiotensin-converting enzyme (ACE) is known to play an important role in the adaptation. The present study was designed to investigate whether the insertion-deletion (I/D) polymorphism of the ACE gene is associated with the level of arterial blood pressure in women before and during pregnancy.
Materials and methods:
The level of blood pressure was measured in 591 Russian women (Central Russia) before and during (37–40 weeks term) pregnancy. The women were divided into three groups which were hypertensive, hypotensive, and normotensive according to blood pressure level. Genotyping of the ACE I/D polymorphism was performed using polymerase chain reaction (PCR) and amplified fragment length polymorphism assay.
Results:
Women with genotype DD showed the highest blood pressure level both during and at the end of pregnancy (p |
| doi_str_mv | 10.1177/1470320313501217 |
| format | Article |
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Malfunctioning of the cardiovascular system during pregnancy may be responsible for adverse effects on the ‘mother-fetus’ system. The cardiovascular system of a pregnant woman develops adaptation to the increased load. Angiotensin-converting enzyme (ACE) is known to play an important role in the adaptation. The present study was designed to investigate whether the insertion-deletion (I/D) polymorphism of the ACE gene is associated with the level of arterial blood pressure in women before and during pregnancy.
Materials and methods:
The level of blood pressure was measured in 591 Russian women (Central Russia) before and during (37–40 weeks term) pregnancy. The women were divided into three groups which were hypertensive, hypotensive, and normotensive according to blood pressure level. Genotyping of the ACE I/D polymorphism was performed using polymerase chain reaction (PCR) and amplified fragment length polymorphism assay.
Results:
Women with genotype DD showed the highest blood pressure level both during and at the end of pregnancy (p<0.05). The highest frequencies of allele D and genotype DD were found in pregnant women in the hypertensive group.
Conclusions:
The deletion variant of the ACE gene is associated with high blood pressure level at the end of pregnancy.</description><identifier>ISSN: 1470-3203</identifier><identifier>EISSN: 1752-8976</identifier><identifier>DOI: 10.1177/1470320313501217</identifier><identifier>PMID: 24150610</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Alleles ; Blood Pressure - genetics ; Female ; Genetic Association Studies ; Genotype ; Humans ; INDEL Mutation - genetics ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic ; Pregnancy ; Young Adult</subject><ispartof>Journal of the renin-angiotensin-aldosterone system, 2015-09, Vol.16 (3), p.623-632</ispartof><rights>The Author(s) 2013</rights><rights>The Author(s) 2013.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-f3809165e029718c57ebca8333446fe4c013471a7f5964b53961d85bff8934ba3</citedby><cites>FETCH-LOGICAL-c379t-f3809165e029718c57ebca8333446fe4c013471a7f5964b53961d85bff8934ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24150610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reshetnikov, Evgeny A</creatorcontrib><creatorcontrib>Akulova, Ludmila Y</creatorcontrib><creatorcontrib>Dobrodomova, Irina S</creatorcontrib><creatorcontrib>Dvornyk, Volodymyr Y</creatorcontrib><creatorcontrib>Polonikov, Alexey V</creatorcontrib><creatorcontrib>Churnosov, Mikhail I</creatorcontrib><title>The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy</title><title>Journal of the renin-angiotensin-aldosterone system</title><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><description>Introduction:
Malfunctioning of the cardiovascular system during pregnancy may be responsible for adverse effects on the ‘mother-fetus’ system. The cardiovascular system of a pregnant woman develops adaptation to the increased load. Angiotensin-converting enzyme (ACE) is known to play an important role in the adaptation. The present study was designed to investigate whether the insertion-deletion (I/D) polymorphism of the ACE gene is associated with the level of arterial blood pressure in women before and during pregnancy.
Materials and methods:
The level of blood pressure was measured in 591 Russian women (Central Russia) before and during (37–40 weeks term) pregnancy. The women were divided into three groups which were hypertensive, hypotensive, and normotensive according to blood pressure level. Genotyping of the ACE I/D polymorphism was performed using polymerase chain reaction (PCR) and amplified fragment length polymorphism assay.
Results:
Women with genotype DD showed the highest blood pressure level both during and at the end of pregnancy (p<0.05). The highest frequencies of allele D and genotype DD were found in pregnant women in the hypertensive group.
Conclusions:
The deletion variant of the ACE gene is associated with high blood pressure level at the end of pregnancy.</description><subject>Adult</subject><subject>Alleles</subject><subject>Blood Pressure - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>Humans</subject><subject>INDEL Mutation - genetics</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>Young Adult</subject><issn>1470-3203</issn><issn>1752-8976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVJaL5676nomIsTjSVZ9jEs-YJAL8nZyPJ418GWXI1N2Ft_euRs2kOhJ414n3lgXsa-g7gCMOYalBEyFxKkFpCD-cJOweg8KytTHKU5xdman7AzolchZKlU_pWd5Aq0KECcst_PO-S9J4xzH3zW4oDrwKcw7McQp11PIw8dnxN2s7nlW_SJJ26JguvtjC1_6-ddUriIltK3GUJo-RSRaImrm7-FET2384cEfbv6Ur711rv9BTvu7ED47fM9Zy93t8-bh-zp5_3j5uYpc9JUc9bJUlRQaBR5ZaB02mDjbCmlVKroUDkBUhmwptNVoRotqwLaUjddV1ZSNVaes8uDd4rh14I012NPDofBegwL1WBAVKUuFCRUHFAXA1HErp5iP9q4r0HUa-_1v72nlR-f9qUZsf278KfoBGQHgOwW69ewRJ-u_b_wHQUmil8</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Reshetnikov, Evgeny A</creator><creator>Akulova, Ludmila Y</creator><creator>Dobrodomova, Irina S</creator><creator>Dvornyk, Volodymyr Y</creator><creator>Polonikov, Alexey V</creator><creator>Churnosov, Mikhail I</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy</title><author>Reshetnikov, Evgeny A ; Akulova, Ludmila Y ; Dobrodomova, Irina S ; Dvornyk, Volodymyr Y ; Polonikov, Alexey V ; Churnosov, Mikhail I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-f3809165e029718c57ebca8333446fe4c013471a7f5964b53961d85bff8934ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Blood Pressure - genetics</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>Humans</topic><topic>INDEL Mutation - genetics</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reshetnikov, Evgeny A</creatorcontrib><creatorcontrib>Akulova, Ludmila Y</creatorcontrib><creatorcontrib>Dobrodomova, Irina S</creatorcontrib><creatorcontrib>Dvornyk, Volodymyr Y</creatorcontrib><creatorcontrib>Polonikov, Alexey V</creatorcontrib><creatorcontrib>Churnosov, Mikhail I</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reshetnikov, Evgeny A</au><au>Akulova, Ludmila Y</au><au>Dobrodomova, Irina S</au><au>Dvornyk, Volodymyr Y</au><au>Polonikov, Alexey V</au><au>Churnosov, Mikhail I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy</atitle><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><date>2015-09</date><risdate>2015</risdate><volume>16</volume><issue>3</issue><spage>623</spage><epage>632</epage><pages>623-632</pages><issn>1470-3203</issn><eissn>1752-8976</eissn><abstract>Introduction:
Malfunctioning of the cardiovascular system during pregnancy may be responsible for adverse effects on the ‘mother-fetus’ system. The cardiovascular system of a pregnant woman develops adaptation to the increased load. Angiotensin-converting enzyme (ACE) is known to play an important role in the adaptation. The present study was designed to investigate whether the insertion-deletion (I/D) polymorphism of the ACE gene is associated with the level of arterial blood pressure in women before and during pregnancy.
Materials and methods:
The level of blood pressure was measured in 591 Russian women (Central Russia) before and during (37–40 weeks term) pregnancy. The women were divided into three groups which were hypertensive, hypotensive, and normotensive according to blood pressure level. Genotyping of the ACE I/D polymorphism was performed using polymerase chain reaction (PCR) and amplified fragment length polymorphism assay.
Results:
Women with genotype DD showed the highest blood pressure level both during and at the end of pregnancy (p<0.05). The highest frequencies of allele D and genotype DD were found in pregnant women in the hypertensive group.
Conclusions:
The deletion variant of the ACE gene is associated with high blood pressure level at the end of pregnancy.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>24150610</pmid><doi>10.1177/1470320313501217</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the renin-angiotensin-aldosterone system, 2015-09, Vol.16 (3), p.623-632 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Alleles Blood Pressure - genetics Female Genetic Association Studies Genotype Humans INDEL Mutation - genetics Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Pregnancy Young Adult |
| title | The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy |
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