Prostaglandin Derivatives: Nonaromatic Phosphodiesterase‑4 Inhibitors from the Soft Coral Sarcophyton ehrenbergi

Ten new prostaglandin derivatives (PGs), sarcoehrendins A–J (1–10), together with five known analogues (11–15) were isolated from the soft coral Sarcophyton ehrenbergi. Compounds 4–8 represented the first examples of PGs featuring an 18-ketone group. The structures including the absolute configurati...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-08, Vol.77 (8), p.1928-1936
Hauptverfasser:	Cheng, Zhong-Bin, Deng, Ya-Lin, Fan, Cheng-Qi, Han, Qing-Hua, Lin, Shu-Ling, Tang, Gui-Hua, Luo, Hai-Bin, Yin, Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthozoa - chemistry China Cyclic Nucleotide Phosphodiesterases, Type 4 - drug effects Molecular Structure Nuclear Magnetic Resonance, Biomolecular Phosphodiesterase 4 Inhibitors - chemistry Phosphodiesterase 4 Inhibitors - isolation & purification Phosphodiesterase 4 Inhibitors - pharmacology Prostaglandins - chemistry Prostaglandins - isolation & purification Prostaglandins - pharmacology Rolipram - pharmacology Structure-Activity Relationship
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