Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult

Several genetically modified mouse models implicated that prolyl-4-hydroxylase domain (PHD) enzymes are critical mediators for protecting tissues from an ischemic insult including myocardial infarction by affecting the stability and activation of hypoxia-inducible factor (HIF)-1 and HIF-2. Thus, the...

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Veröffentlicht in:	Pflügers Archiv 2015-10, Vol.467 (10), p.2141-2149
Hauptverfasser:	Vogler, Melanie, Zieseniss, Anke, Hesse, Amke R., Levent, Elif, Tiburcy, Malte, Heinze, Eva, Burzlaff, Nicolai, Schley, Gunnar, Eckardt, Kai Uwe, Willam, Carsten, Katschinski, Dörthe M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cardiotonic Agents - therapeutic use Cell Biology Glycine - analogs & derivatives Glycine - pharmacology Glycine - therapeutic use Human Physiology Hypoxia-Inducible Factor 1 - metabolism Ischemic Postconditioning Ischemic Preconditioning, Myocardial Isoquinolines - pharmacology Isoquinolines - therapeutic use Male Mice Mice, Inbred C57BL Molecular and Cellular Mechanisms of Disease Molecular Medicine Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Neurosciences Prolyl-Hydroxylase Inhibitors - therapeutic use Receptors Transcription Factors - metabolism
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