Crystal Structures of Yersinia enterocolitica Salicylate Synthase and its Complex with the Reaction Products Salicylate and Pyruvate

The salicylate synthase, Irp9, from Yersinia enterocolitica is involved in the biosynthesis of the siderophore yersiniabactin. It is a bifunctional enzyme that forms salicylate and pyruvate from chorismate and water via the intermediate isochorismate. Here we report the first crystal structure of Ir...

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Veröffentlicht in:	Journal of molecular biology 2006-03, Vol.357 (2), p.524-534
Hauptverfasser:	Kerbarh, Olivier, Chirgadze, Dimitri Y., Blundell, Tom L., Abell, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence anthranilate synthase Binding Sites chorismate Crystallography, X-Ray Dimerization Lyases - chemistry Lyases - genetics Lyases - metabolism Models, Molecular Molecular Sequence Data Molecular Structure Mutation Protein Structure, Quaternary Pyruvic Acid - chemistry Pyruvic Acid - metabolism salicylate Salicylates - chemistry Salicylates - metabolism Sequence Alignment siderophore Yersinia Yersinia enterocolitica Yersinia enterocolitica - enzymology
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