A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene, mdr1a, Spontaneously Develop Colitis

The murine multiple drug resistance (mdr) gene, mdr1a, encodes a 170-kDa transmembrane protein that is expressed in many tissues including intestinal epithelial cells, a subset of lymphoid cells and hematopoietic cells. We report that mdr1a knockout (mdr1a-/-) mice are susceptible to developing a se...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-11, Vol.161 (10), p.5733-5744
Hauptverfasser:	Panwala, Chetan M, Jones, Jon C, Viney, Joanne L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Bacterial Agents - therapeutic use Antigens, Bacterial - immunology ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - deficiency ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Colon - immunology Colon - microbiology Epithelial Cells - metabolism Epithelial Cells - pathology Female Gene Expression Regulation - immunology Genes, MDR - immunology Immunoglobulins - biosynthesis Immunoglobulins - blood Incidence Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - prevention & control Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Lymphocyte Activation Lymphocytes - metabolism Lymphocytes - pathology Lymphoid Tissue - immunology Lymphoid Tissue - pathology Male Mice Mice, Inbred Strains Mice, Knockout
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