Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole
Endocrine-disrupting chemicals (EDCs) are synthetic chemicals that arise from sources such as pesticides and have the ability to mimic or inhibit gonadal steroid hormones. The objective of this research was to examine the effects of EDCs on the behaviors associated with monogamy and the expression o...
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Veröffentlicht in: | Neurotoxicology and teratology 2006-01, Vol.28 (1), p.103-110 |
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creator | Engell, Miles Dean Godwin, John Young, Larry J. Vandenbergh, John G. |
description | Endocrine-disrupting chemicals (EDCs) are synthetic chemicals that arise from sources such as pesticides and have the ability to mimic or inhibit gonadal steroid hormones. The objective of this research was to examine the effects of EDCs on the behaviors associated with monogamy and the expression of related neuropeptide receptors. Pine voles, a novel experimental mammal, were chosen because they display strong monogamous pair bonding. Female pine voles were orally administered estrogenic diethylstilbestrol (DES) and methoxychlor (MXC) or oil control throughout gestation and lactation of pups. Exposed pups were tested as adults. Preference for the mate and maternal behaviors were assessed. While the ability to form partner preferences was intact, DES-exposed females showed increased aggression toward a stranger, while MXC exposed females showed a strong trend toward spending more time alone. Oxytocin (OT) receptor binding in the brain was assessed for possible effects on this behaviorally important neuropeptide signaling system. The cingulate cortex showed a reduction in OT binding in the MXC group. These findings demonstrate that exposure to EDCs during pre- and neonatal development can alter female adult neural phenotype and behavior related to monogamous behavior traits. |
doi_str_mv | 10.1016/j.ntt.2005.10.002 |
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The objective of this research was to examine the effects of EDCs on the behaviors associated with monogamy and the expression of related neuropeptide receptors. Pine voles, a novel experimental mammal, were chosen because they display strong monogamous pair bonding. Female pine voles were orally administered estrogenic diethylstilbestrol (DES) and methoxychlor (MXC) or oil control throughout gestation and lactation of pups. Exposed pups were tested as adults. Preference for the mate and maternal behaviors were assessed. While the ability to form partner preferences was intact, DES-exposed females showed increased aggression toward a stranger, while MXC exposed females showed a strong trend toward spending more time alone. Oxytocin (OT) receptor binding in the brain was assessed for possible effects on this behaviorally important neuropeptide signaling system. The cingulate cortex showed a reduction in OT binding in the MXC group. These findings demonstrate that exposure to EDCs during pre- and neonatal development can alter female adult neural phenotype and behavior related to monogamous behavior traits.</description><subject>Aggression - drug effects</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Arvicolinae</subject><subject>Behavior, Animal - drug effects</subject><subject>Binding, Competitive - drug effects</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>DES</subject><subject>Diethylstilbestrol - toxicity</subject><subject>Disease Models, Animal</subject><subject>Endocrine disruption</subject><subject>Estradiol Congeners - toxicity</subject><subject>Female</subject><subject>Gyrus Cinguli - drug effects</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Medical sciences</subject><subject>Methoxychlor</subject><subject>Methoxychlor - toxicity</subject><subject>Microtus pinetorum</subject><subject>Monogamy</subject><subject>Oxytocin</subject><subject>Pair Bond</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Pine vole</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - pathology</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Receptors, Oxytocin - drug effects</subject><subject>Receptors, Oxytocin - metabolism</subject><subject>Social Behavior</subject><subject>Toxicology</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAURUVpaSZpPyCboE278_RJ8lgyWZXQNoWBdtGshSw_NxpsyZHkIfn7ysxAdgWB0HvnXsQh5JrBlgFrvhy2PuctB9iV9xaAvyEbpiSvWinUW7IB1fIKRMMvyGVKBwCQDYP35II1AqRq5IYMvzE6b7IZKT7PIS0RaQ4UfR9sWSDtXYrLnJ3_S22Y5rD4PlEzZoyJdvhoji5EanxPu2icp-XkR6QDTmZEOq8NxzDiB_JuMGPCj-f7ijx8__bn7r7a__rx8-7rvrK1VLlSjNm6s6aFnRW1MBxBWaWgNpy3gneAzPAWTQ9CIuNDN9Q16xrZNUUCNFJckc-n3jmGpwVT1pNLFsfReAxL0kwykCBUAdkJtDGkFHHQc3STiS-agV7l6oMucvUqdx0VuSVzcy5fugn718TZZgE-nQGTrBmHaLx16ZWTOyXqeuVuTxwWFUeHUSfr0FvsXUSbdR_cf77xD3BVl-g</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Engell, Miles Dean</creator><creator>Godwin, John</creator><creator>Young, Larry J.</creator><creator>Vandenbergh, John G.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20060101</creationdate><title>Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole</title><author>Engell, Miles Dean ; Godwin, John ; Young, Larry J. ; Vandenbergh, John G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-811c4bca905c343a2e08c8804a22932b0e1a29ead037e12fbf441b67b62000673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aggression - drug effects</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Arvicolinae</topic><topic>Behavior, Animal - drug effects</topic><topic>Binding, Competitive - drug effects</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>DES</topic><topic>Diethylstilbestrol - toxicity</topic><topic>Disease Models, Animal</topic><topic>Endocrine disruption</topic><topic>Estradiol Congeners - toxicity</topic><topic>Female</topic><topic>Gyrus Cinguli - drug effects</topic><topic>Gyrus Cinguli - metabolism</topic><topic>Medical sciences</topic><topic>Methoxychlor</topic><topic>Methoxychlor - toxicity</topic><topic>Microtus pinetorum</topic><topic>Monogamy</topic><topic>Oxytocin</topic><topic>Pair Bond</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Pine vole</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - pathology</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Receptors, Oxytocin - drug effects</topic><topic>Receptors, Oxytocin - metabolism</topic><topic>Social Behavior</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engell, Miles Dean</creatorcontrib><creatorcontrib>Godwin, John</creatorcontrib><creatorcontrib>Young, Larry J.</creatorcontrib><creatorcontrib>Vandenbergh, John G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engell, Miles Dean</au><au>Godwin, John</au><au>Young, Larry J.</au><au>Vandenbergh, John G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>28</volume><issue>1</issue><spage>103</spage><epage>110</epage><pages>103-110</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>Endocrine-disrupting chemicals (EDCs) are synthetic chemicals that arise from sources such as pesticides and have the ability to mimic or inhibit gonadal steroid hormones. The objective of this research was to examine the effects of EDCs on the behaviors associated with monogamy and the expression of related neuropeptide receptors. Pine voles, a novel experimental mammal, were chosen because they display strong monogamous pair bonding. Female pine voles were orally administered estrogenic diethylstilbestrol (DES) and methoxychlor (MXC) or oil control throughout gestation and lactation of pups. Exposed pups were tested as adults. Preference for the mate and maternal behaviors were assessed. While the ability to form partner preferences was intact, DES-exposed females showed increased aggression toward a stranger, while MXC exposed females showed a strong trend toward spending more time alone. Oxytocin (OT) receptor binding in the brain was assessed for possible effects on this behaviorally important neuropeptide signaling system. The cingulate cortex showed a reduction in OT binding in the MXC group. These findings demonstrate that exposure to EDCs during pre- and neonatal development can alter female adult neural phenotype and behavior related to monogamous behavior traits.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16307867</pmid><doi>10.1016/j.ntt.2005.10.002</doi><tpages>8</tpages></addata></record> |
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subjects | Aggression - drug effects Animals Animals, Newborn Arvicolinae Behavior, Animal - drug effects Binding, Competitive - drug effects Biological and medical sciences Brain - drug effects Brain - pathology Brain - physiopathology DES Diethylstilbestrol - toxicity Disease Models, Animal Endocrine disruption Estradiol Congeners - toxicity Female Gyrus Cinguli - drug effects Gyrus Cinguli - metabolism Medical sciences Methoxychlor Methoxychlor - toxicity Microtus pinetorum Monogamy Oxytocin Pair Bond Pesticides, fertilizers and other agrochemicals toxicology Pine vole Pregnancy Prenatal Exposure Delayed Effects - pathology Prenatal Exposure Delayed Effects - physiopathology Receptors, Oxytocin - drug effects Receptors, Oxytocin - metabolism Social Behavior Toxicology |
title | Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole |
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