Phenolic compounds from the bark of Oroxylum indicum activate the Ngn2 promoter

A reporter gene assay that detects neurogenin 2 (Ngn2) promoter activity was utilized to identify compounds that induce neuronal differentiation. Ngn2 is a basic helix-loop-helix transcription factor that activates transcription of pro-neural genes. Using this assay system and an activity-guided app...

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Veröffentlicht in:	Journal of natural medicines 2015-10, Vol.69 (4), p.589-594
Hauptverfasser:	Fuentes, Rolly G, Arai, Midori A, Sadhu, Samir K, Ahmed, Firoj, Ishibashi, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	apigenin baicalin bark basic helix-loop-helix transcription factors Basic Helix-Loop-Helix Transcription Factors - genetics Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Medicinal Chemistry methanol Molecular Structure Nerve Tissue Proteins - genetics Oroxylum indicum Pharmacology/Toxicology Pharmacy phenolic compounds Phenols - analysis Phenols - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Plant Sciences reporter genes stem cells Transcription Factors - genetics
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