Physical activity, fitness, and vascular health in patients with asthma
High levels of the proinflammatory cytokines IL-6, C-reactive protein, and tumor necrosis factor-alpha are elevated in asthma, and all are associated with increased CVD risk.2,3 Reduced endothelial vasodilation is seen in early stages of CVD development and is predictive of CVD.4 Patients with asthm...
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| creator | Moore, Linn E., BSc Bhutani, Mohit, MD Petersen, Stewart R., PhD McMurtry, M. Sean, MD, PhD Byers, Bradley W., BSc Tedjasaputra, Vincent, MSc Stickland, Michael K., PhD |
| description | High levels of the proinflammatory cytokines IL-6, C-reactive protein, and tumor necrosis factor-alpha are elevated in asthma, and all are associated with increased CVD risk.2,3 Reduced endothelial vasodilation is seen in early stages of CVD development and is predictive of CVD.4 Patients with asthma have reduced endothelial function and increased arterial stiffness than do those without asthma.5,6 Systemic inflammation impairs endothelial function7 and increases arterial stiffness,8 but it is unknown whether there is a connection between systemic inflammation, vascular function, and arterial stiffness in subjects with asthma. Characteristic Control Asthma P value (2-tailed) Sample size, n (male/female) 16 (8/8) 16 (10/6) .72 Age (y) 26.6 ± 5.2 27.8 ± 6.1 .58 BMI (kg/m2) 24.7 ± 3.5 24.6 ± 4.6 .96 FEV1 prebronchodilator (% predicted) 96.3 ± 12.1 81.3 ± 15.1 .004 FEV1 postbronchodilator (% predicted) 100.9 ± 13.2 91.6 ± 12.6 .051 Feno (ppb) 17.9 ± 8.5 37.3 ± 40.9 .16 Asthma Control Questionnaire score 0.1 ± 0.2 1.0 ± 0.4 |
| doi_str_mv | 10.1016/j.jaci.2015.02.033 |
| format | Article |
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Sean, MD, PhD ; Byers, Bradley W., BSc ; Tedjasaputra, Vincent, MSc ; Stickland, Michael K., PhD</creator><creatorcontrib>Moore, Linn E., BSc ; Bhutani, Mohit, MD ; Petersen, Stewart R., PhD ; McMurtry, M. Sean, MD, PhD ; Byers, Bradley W., BSc ; Tedjasaputra, Vincent, MSc ; Stickland, Michael K., PhD</creatorcontrib><description>High levels of the proinflammatory cytokines IL-6, C-reactive protein, and tumor necrosis factor-alpha are elevated in asthma, and all are associated with increased CVD risk.2,3 Reduced endothelial vasodilation is seen in early stages of CVD development and is predictive of CVD.4 Patients with asthma have reduced endothelial function and increased arterial stiffness than do those without asthma.5,6 Systemic inflammation impairs endothelial function7 and increases arterial stiffness,8 but it is unknown whether there is a connection between systemic inflammation, vascular function, and arterial stiffness in subjects with asthma. Characteristic Control Asthma P value (2-tailed) Sample size, n (male/female) 16 (8/8) 16 (10/6) .72 Age (y) 26.6 ± 5.2 27.8 ± 6.1 .58 BMI (kg/m2) 24.7 ± 3.5 24.6 ± 4.6 .96 FEV1 prebronchodilator (% predicted) 96.3 ± 12.1 81.3 ± 15.1 .004 FEV1 postbronchodilator (% predicted) 100.9 ± 13.2 91.6 ± 12.6 .051 Feno (ppb) 17.9 ± 8.5 37.3 ± 40.9 .16 Asthma Control Questionnaire score 0.1 ± 0.2 1.0 ± 0.4 <.001 Allergies (% yes) 18.8 57.1 .03 SABA usage (%) 0.0 56.3 <.001 ICS usage (%) 0.0 18.8 <.001 Combination ICS + LABA usage (%) 0.0 43.8 <.001 Physical activity, steps/d 10,711 ± 2,675 11,125 ± 5,487 .79 Fitness (relative V.O2max) (mL/kg/min % predicted) 106.1 ± 15.9 97.1 ±23.3 .21 Mean arterial pressure (mmHg) 79 ± 5 82 ± 10 .34 Heart rate (bpm) 55.7 ± 5.8 59.3 ± 6.0 .10 Total cholesterol (mmol/L) 3.7 ± 0.9 3.9 ± 1.4 .86 HDL (mmol/L) 1.4 ± 0.2 1.4 ± 0.4 .92 Fasting glucose (mmol/L) 3.9 ± 0.4 3.9 ± 0.4 .81 CRP (mg/L) 2.3 ± 3.83 3.6 ± 3.5 .46 IL-6 (pg/mL) 8.6 ± 5.9 6.9 ± 3.5 .35 TNF-α (pg/mL) 16.5 ± 5.1 16.3 ± 2.8 .91 Table I Subjects' characteristics Values are mean ± SD unless indicated otherwise.BMI, Body mass index; bpm, beats per minute; CRP, C-reactive protein; Feno, fraction of exhaled nitric oxide; HDL, high-density lipoprotein; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; SABA, short-acting beta-agonist; TNF-α, tumor necrosis factor-alpha; V.O2, rate of oxygen consumption.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2015.02.033</identifier><identifier>PMID: 25913103</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Allergy and Immunology ; Asthma ; Asthma - physiopathology ; Blood pressure ; Case-Control Studies ; Cholesterol ; Endothelium, Vascular - physiopathology ; Exercise ; Female ; Humans ; Male ; Motor Activity ; Physical Fitness ; Surveys and Questionnaires ; Tumor necrosis factor-TNF ; Vascular Stiffness</subject><ispartof>Journal of allergy and clinical immunology, 2015-09, Vol.136 (3), p.809-811.e3</ispartof><rights>The Authors</rights><rights>2015 The Authors</rights><rights>Copyright Elsevier Limited Sep 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-9518381d9bbf6f12c673b525964acab9be0a68b26e73f72d23bb654daa044c5d3</citedby><cites>FETCH-LOGICAL-c553t-9518381d9bbf6f12c673b525964acab9be0a68b26e73f72d23bb654daa044c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674915003395$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25913103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, Linn E., BSc</creatorcontrib><creatorcontrib>Bhutani, Mohit, MD</creatorcontrib><creatorcontrib>Petersen, Stewart R., PhD</creatorcontrib><creatorcontrib>McMurtry, M. Sean, MD, PhD</creatorcontrib><creatorcontrib>Byers, Bradley W., BSc</creatorcontrib><creatorcontrib>Tedjasaputra, Vincent, MSc</creatorcontrib><creatorcontrib>Stickland, Michael K., PhD</creatorcontrib><title>Physical activity, fitness, and vascular health in patients with asthma</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>High levels of the proinflammatory cytokines IL-6, C-reactive protein, and tumor necrosis factor-alpha are elevated in asthma, and all are associated with increased CVD risk.2,3 Reduced endothelial vasodilation is seen in early stages of CVD development and is predictive of CVD.4 Patients with asthma have reduced endothelial function and increased arterial stiffness than do those without asthma.5,6 Systemic inflammation impairs endothelial function7 and increases arterial stiffness,8 but it is unknown whether there is a connection between systemic inflammation, vascular function, and arterial stiffness in subjects with asthma. Characteristic Control Asthma P value (2-tailed) Sample size, n (male/female) 16 (8/8) 16 (10/6) .72 Age (y) 26.6 ± 5.2 27.8 ± 6.1 .58 BMI (kg/m2) 24.7 ± 3.5 24.6 ± 4.6 .96 FEV1 prebronchodilator (% predicted) 96.3 ± 12.1 81.3 ± 15.1 .004 FEV1 postbronchodilator (% predicted) 100.9 ± 13.2 91.6 ± 12.6 .051 Feno (ppb) 17.9 ± 8.5 37.3 ± 40.9 .16 Asthma Control Questionnaire score 0.1 ± 0.2 1.0 ± 0.4 <.001 Allergies (% yes) 18.8 57.1 .03 SABA usage (%) 0.0 56.3 <.001 ICS usage (%) 0.0 18.8 <.001 Combination ICS + LABA usage (%) 0.0 43.8 <.001 Physical activity, steps/d 10,711 ± 2,675 11,125 ± 5,487 .79 Fitness (relative V.O2max) (mL/kg/min % predicted) 106.1 ± 15.9 97.1 ±23.3 .21 Mean arterial pressure (mmHg) 79 ± 5 82 ± 10 .34 Heart rate (bpm) 55.7 ± 5.8 59.3 ± 6.0 .10 Total cholesterol (mmol/L) 3.7 ± 0.9 3.9 ± 1.4 .86 HDL (mmol/L) 1.4 ± 0.2 1.4 ± 0.4 .92 Fasting glucose (mmol/L) 3.9 ± 0.4 3.9 ± 0.4 .81 CRP (mg/L) 2.3 ± 3.83 3.6 ± 3.5 .46 IL-6 (pg/mL) 8.6 ± 5.9 6.9 ± 3.5 .35 TNF-α (pg/mL) 16.5 ± 5.1 16.3 ± 2.8 .91 Table I Subjects' characteristics Values are mean ± SD unless indicated otherwise.BMI, Body mass index; bpm, beats per minute; CRP, C-reactive protein; Feno, fraction of exhaled nitric oxide; HDL, high-density lipoprotein; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; SABA, short-acting beta-agonist; TNF-α, tumor necrosis factor-alpha; V.O2, rate of oxygen consumption.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Asthma</subject><subject>Asthma - physiopathology</subject><subject>Blood pressure</subject><subject>Case-Control Studies</subject><subject>Cholesterol</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Motor Activity</subject><subject>Physical Fitness</subject><subject>Surveys and Questionnaires</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vascular Stiffness</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo7rj6B7yQgjdebLv5aNIGRJBF14UFF9TrcJKeMqmddkzSkfn3psyqsBd7FRKe93DyvIS8ZrRilKnLoRrA-YpTJivKKyrEE7JhVDelarl8SjaUalaqptZn5EWMA8130ern5IxLzQSjYkOu77bH6B2MBbjkDz4dL4repwljvChg6ooDRLeMEIotwpi2hZ-KPSSPU4rFb58fIKbtDl6SZz2MEV_dn-fkx-dP36--lLdfr2-uPt6WTkqRSi1ZK1rWaWt71TPuVCOszOuoGhxYbZGCai1X2Ii-4R0X1ipZdwC0rp3sxDl5d5q7D_OvBWMyOx8djiNMOC_RsIbRHBC6yejbB-gwL2HK22WKal4zVatM8RPlwhxjwN7sg99BOBpGzarZDGbVbFbNhnKTNefQm_vRi91h9y_y12sG3p8AzC4OHoOJLjtz2PmALplu9o_P__Ag7kY_rTX9xCPG__8wMQfMt7XotWcmaY5rKf4Ar2WhmA</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Moore, Linn E., BSc</creator><creator>Bhutani, Mohit, MD</creator><creator>Petersen, Stewart R., PhD</creator><creator>McMurtry, M. 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Sean, MD, PhD</creatorcontrib><creatorcontrib>Byers, Bradley W., BSc</creatorcontrib><creatorcontrib>Tedjasaputra, Vincent, MSc</creatorcontrib><creatorcontrib>Stickland, Michael K., PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, Linn E., BSc</au><au>Bhutani, Mohit, MD</au><au>Petersen, Stewart R., PhD</au><au>McMurtry, M. Sean, MD, PhD</au><au>Byers, Bradley W., BSc</au><au>Tedjasaputra, Vincent, MSc</au><au>Stickland, Michael K., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical activity, fitness, and vascular health in patients with asthma</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>136</volume><issue>3</issue><spage>809</spage><epage>811.e3</epage><pages>809-811.e3</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>High levels of the proinflammatory cytokines IL-6, C-reactive protein, and tumor necrosis factor-alpha are elevated in asthma, and all are associated with increased CVD risk.2,3 Reduced endothelial vasodilation is seen in early stages of CVD development and is predictive of CVD.4 Patients with asthma have reduced endothelial function and increased arterial stiffness than do those without asthma.5,6 Systemic inflammation impairs endothelial function7 and increases arterial stiffness,8 but it is unknown whether there is a connection between systemic inflammation, vascular function, and arterial stiffness in subjects with asthma. Characteristic Control Asthma P value (2-tailed) Sample size, n (male/female) 16 (8/8) 16 (10/6) .72 Age (y) 26.6 ± 5.2 27.8 ± 6.1 .58 BMI (kg/m2) 24.7 ± 3.5 24.6 ± 4.6 .96 FEV1 prebronchodilator (% predicted) 96.3 ± 12.1 81.3 ± 15.1 .004 FEV1 postbronchodilator (% predicted) 100.9 ± 13.2 91.6 ± 12.6 .051 Feno (ppb) 17.9 ± 8.5 37.3 ± 40.9 .16 Asthma Control Questionnaire score 0.1 ± 0.2 1.0 ± 0.4 <.001 Allergies (% yes) 18.8 57.1 .03 SABA usage (%) 0.0 56.3 <.001 ICS usage (%) 0.0 18.8 <.001 Combination ICS + LABA usage (%) 0.0 43.8 <.001 Physical activity, steps/d 10,711 ± 2,675 11,125 ± 5,487 .79 Fitness (relative V.O2max) (mL/kg/min % predicted) 106.1 ± 15.9 97.1 ±23.3 .21 Mean arterial pressure (mmHg) 79 ± 5 82 ± 10 .34 Heart rate (bpm) 55.7 ± 5.8 59.3 ± 6.0 .10 Total cholesterol (mmol/L) 3.7 ± 0.9 3.9 ± 1.4 .86 HDL (mmol/L) 1.4 ± 0.2 1.4 ± 0.4 .92 Fasting glucose (mmol/L) 3.9 ± 0.4 3.9 ± 0.4 .81 CRP (mg/L) 2.3 ± 3.83 3.6 ± 3.5 .46 IL-6 (pg/mL) 8.6 ± 5.9 6.9 ± 3.5 .35 TNF-α (pg/mL) 16.5 ± 5.1 16.3 ± 2.8 .91 Table I Subjects' characteristics Values are mean ± SD unless indicated otherwise.BMI, Body mass index; bpm, beats per minute; CRP, C-reactive protein; Feno, fraction of exhaled nitric oxide; HDL, high-density lipoprotein; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; SABA, short-acting beta-agonist; TNF-α, tumor necrosis factor-alpha; V.O2, rate of oxygen consumption.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25913103</pmid><doi>10.1016/j.jaci.2015.02.033</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Allergy and Immunology Asthma Asthma - physiopathology Blood pressure Case-Control Studies Cholesterol Endothelium, Vascular - physiopathology Exercise Female Humans Male Motor Activity Physical Fitness Surveys and Questionnaires Tumor necrosis factor-TNF Vascular Stiffness |
| title | Physical activity, fitness, and vascular health in patients with asthma |
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