Predictive value of the Groningen Frailty Indicator for treatment outcomes in elderly patients after head and neck, or skin cancer surgery in a retrospective cohort
Objectives Careful selection of patients eligible for extensive head and neck cancer surgery is extremely important. A reliable predictor for postoperative outcomes in the vulnerable elderly population is not yet available. The concept of frailty describes a clinical state of increased vulnerability...
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| Veröffentlicht in: | Clinical otolaryngology 2015-10, Vol.40 (5), p.474-482 |
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| creator | Bras, L. Peters, T.T.A. Wedman, J. Plaat, B.E.C. Witjes, M.J.H. van Leeuwen, B.L. van der Laan, B.F.A.M. Halmos, G.B. |
| description | Objectives
Careful selection of patients eligible for extensive head and neck cancer surgery is extremely important. A reliable predictor for postoperative outcomes in the vulnerable elderly population is not yet available. The concept of frailty describes a clinical state of increased vulnerability and can be assessed using frailty tests, such as the Groningen Frailty Indicator. In the current study, the influence of Groningen Frailty Indicator‐measured frailty on clinical outcome was investigated in elderly patients surgically treated for head and neck cancer.
Design
Retrospective, explorative cohort study.
Setting
Tertiary referral centre.
Participants
A total of 90 patients of 65 years and older receiving surgical treatment for head and neck cancer with different primary sites.
Main outcome measures
The influence of frailty (Groningen Frailty Indicator) on postoperative complications (Clavien–Dindo classification), subjective postoperative experience of both patient and surgeon and survival were analysed.
Results
A total of 36 patients were considered as frail (40%). Postoperative complications could not be predicted by frailty status. However, the Groningen Frailty Indicator dimension ‘health problems’ was a significant predictor for postoperative complications (P = 0.020). Unlike age and comorbidity, frailty was associated with a poor subjective patients’ experience of the postoperative recovery (P |
| doi_str_mv | 10.1111/coa.12409 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1710653898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1710653898</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3179-db9132a0870978fafc782c748e6119380139a6bd07dd4f36fe7895eaaab647d33</originalsourceid><addsrcrecordid>eNpdkcFu1DAQhiMEoqVw4AWQJS4cSGvHSRwfqxVdKioKUqESF2vWnnTdTezFdgp5Hx4Ut1v2gKWRR_q_fzSavyheM3rM8jvRHo5ZVVP5pDhkopZlXXft030vuoPiRYy3lNacCva8OKga0dSMisPiz5eAxupk75DcwTAh8T1JayTL4J11N-jIWQA7pJmcuwxC8oH0uVJASCO6RPyUtB8xEusIDgbDMJMtJJu1SKBPGMgawRBwhjjUm_ck2-Mm0xqczmqcwg2G-d4PJGAKPm5xt5L2ax_Sy-JZD0PEV4__UfHt7MPV4mN5cbk8X5xelJYzIUuzkoxXQDtBpeh66LXoKi3qDlvGJO8o4xLalaHCmLrnbY-ikw0CwKqtheH8qHi3m7sN_ueEManRRo3DAA79FBUTjLYN72SX0bf_obd-Ci5vlykqM8Iqmak3j9S0GtGobbAjhFn9u38GTnbALzvgvNcZVffBqhyseghWLS5PH5rsKHcOGxP-3jsgbFQruGjU9eelEp--s6_XP65Uy_8CePKmgQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1709898129</pqid></control><display><type>article</type><title>Predictive value of the Groningen Frailty Indicator for treatment outcomes in elderly patients after head and neck, or skin cancer surgery in a retrospective cohort</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Bras, L. ; Peters, T.T.A. ; Wedman, J. ; Plaat, B.E.C. ; Witjes, M.J.H. ; van Leeuwen, B.L. ; van der Laan, B.F.A.M. ; Halmos, G.B.</creator><creatorcontrib>Bras, L. ; Peters, T.T.A. ; Wedman, J. ; Plaat, B.E.C. ; Witjes, M.J.H. ; van Leeuwen, B.L. ; van der Laan, B.F.A.M. ; Halmos, G.B.</creatorcontrib><description>Objectives
Careful selection of patients eligible for extensive head and neck cancer surgery is extremely important. A reliable predictor for postoperative outcomes in the vulnerable elderly population is not yet available. The concept of frailty describes a clinical state of increased vulnerability and can be assessed using frailty tests, such as the Groningen Frailty Indicator. In the current study, the influence of Groningen Frailty Indicator‐measured frailty on clinical outcome was investigated in elderly patients surgically treated for head and neck cancer.
Design
Retrospective, explorative cohort study.
Setting
Tertiary referral centre.
Participants
A total of 90 patients of 65 years and older receiving surgical treatment for head and neck cancer with different primary sites.
Main outcome measures
The influence of frailty (Groningen Frailty Indicator) on postoperative complications (Clavien–Dindo classification), subjective postoperative experience of both patient and surgeon and survival were analysed.
Results
A total of 36 patients were considered as frail (40%). Postoperative complications could not be predicted by frailty status. However, the Groningen Frailty Indicator dimension ‘health problems’ was a significant predictor for postoperative complications (P = 0.020). Unlike age and comorbidity, frailty was associated with a poor subjective patients’ experience of the postoperative recovery (P < 0.01). Although not statistically significant, survival analysis showed a worse 5‐year overall survival in the frail group (33%) versus the non‐frail group (74%).
Conclusions
Analysis of frailty could identify elderly patients who might suffer more than expected during the postoperative period after head and neck cancer surgery. In this study, frailty was not identified as a new predictor of complications after head and neck cancer surgery.</description><identifier>ISSN: 1749-4478</identifier><identifier>EISSN: 1749-4486</identifier><identifier>DOI: 10.1111/coa.12409</identifier><identifier>PMID: 25754107</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Analysis of Variance ; Female ; Frail Elderly ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - surgery ; Humans ; Kaplan-Meier Estimate ; Male ; Neoplasm Staging ; Postoperative Complications ; Prognosis ; Retrospective Studies ; Skin Neoplasms - mortality ; Skin Neoplasms - surgery ; Treatment Outcome</subject><ispartof>Clinical otolaryngology, 2015-10, Vol.40 (5), p.474-482</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcoa.12409$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcoa.12409$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25754107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bras, L.</creatorcontrib><creatorcontrib>Peters, T.T.A.</creatorcontrib><creatorcontrib>Wedman, J.</creatorcontrib><creatorcontrib>Plaat, B.E.C.</creatorcontrib><creatorcontrib>Witjes, M.J.H.</creatorcontrib><creatorcontrib>van Leeuwen, B.L.</creatorcontrib><creatorcontrib>van der Laan, B.F.A.M.</creatorcontrib><creatorcontrib>Halmos, G.B.</creatorcontrib><title>Predictive value of the Groningen Frailty Indicator for treatment outcomes in elderly patients after head and neck, or skin cancer surgery in a retrospective cohort</title><title>Clinical otolaryngology</title><addtitle>Clin Otolaryngol</addtitle><description>Objectives
Careful selection of patients eligible for extensive head and neck cancer surgery is extremely important. A reliable predictor for postoperative outcomes in the vulnerable elderly population is not yet available. The concept of frailty describes a clinical state of increased vulnerability and can be assessed using frailty tests, such as the Groningen Frailty Indicator. In the current study, the influence of Groningen Frailty Indicator‐measured frailty on clinical outcome was investigated in elderly patients surgically treated for head and neck cancer.
Design
Retrospective, explorative cohort study.
Setting
Tertiary referral centre.
Participants
A total of 90 patients of 65 years and older receiving surgical treatment for head and neck cancer with different primary sites.
Main outcome measures
The influence of frailty (Groningen Frailty Indicator) on postoperative complications (Clavien–Dindo classification), subjective postoperative experience of both patient and surgeon and survival were analysed.
Results
A total of 36 patients were considered as frail (40%). Postoperative complications could not be predicted by frailty status. However, the Groningen Frailty Indicator dimension ‘health problems’ was a significant predictor for postoperative complications (P = 0.020). Unlike age and comorbidity, frailty was associated with a poor subjective patients’ experience of the postoperative recovery (P < 0.01). Although not statistically significant, survival analysis showed a worse 5‐year overall survival in the frail group (33%) versus the non‐frail group (74%).
Conclusions
Analysis of frailty could identify elderly patients who might suffer more than expected during the postoperative period after head and neck cancer surgery. In this study, frailty was not identified as a new predictor of complications after head and neck cancer surgery.</description><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Female</subject><subject>Frail Elderly</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Neoplasm Staging</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms - mortality</subject><subject>Skin Neoplasms - surgery</subject><subject>Treatment Outcome</subject><issn>1749-4478</issn><issn>1749-4486</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFu1DAQhiMEoqVw4AWQJS4cSGvHSRwfqxVdKioKUqESF2vWnnTdTezFdgp5Hx4Ut1v2gKWRR_q_fzSavyheM3rM8jvRHo5ZVVP5pDhkopZlXXft030vuoPiRYy3lNacCva8OKga0dSMisPiz5eAxupk75DcwTAh8T1JayTL4J11N-jIWQA7pJmcuwxC8oH0uVJASCO6RPyUtB8xEusIDgbDMJMtJJu1SKBPGMgawRBwhjjUm_ck2-Mm0xqczmqcwg2G-d4PJGAKPm5xt5L2ax_Sy-JZD0PEV4__UfHt7MPV4mN5cbk8X5xelJYzIUuzkoxXQDtBpeh66LXoKi3qDlvGJO8o4xLalaHCmLrnbY-ikw0CwKqtheH8qHi3m7sN_ueEManRRo3DAA79FBUTjLYN72SX0bf_obd-Ci5vlykqM8Iqmak3j9S0GtGobbAjhFn9u38GTnbALzvgvNcZVffBqhyseghWLS5PH5rsKHcOGxP-3jsgbFQruGjU9eelEp--s6_XP65Uy_8CePKmgQ</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Bras, L.</creator><creator>Peters, T.T.A.</creator><creator>Wedman, J.</creator><creator>Plaat, B.E.C.</creator><creator>Witjes, M.J.H.</creator><creator>van Leeuwen, B.L.</creator><creator>van der Laan, B.F.A.M.</creator><creator>Halmos, G.B.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Predictive value of the Groningen Frailty Indicator for treatment outcomes in elderly patients after head and neck, or skin cancer surgery in a retrospective cohort</title><author>Bras, L. ; Peters, T.T.A. ; Wedman, J. ; Plaat, B.E.C. ; Witjes, M.J.H. ; van Leeuwen, B.L. ; van der Laan, B.F.A.M. ; Halmos, G.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3179-db9132a0870978fafc782c748e6119380139a6bd07dd4f36fe7895eaaab647d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Female</topic><topic>Frail Elderly</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Neoplasm Staging</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms - mortality</topic><topic>Skin Neoplasms - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bras, L.</creatorcontrib><creatorcontrib>Peters, T.T.A.</creatorcontrib><creatorcontrib>Wedman, J.</creatorcontrib><creatorcontrib>Plaat, B.E.C.</creatorcontrib><creatorcontrib>Witjes, M.J.H.</creatorcontrib><creatorcontrib>van Leeuwen, B.L.</creatorcontrib><creatorcontrib>van der Laan, B.F.A.M.</creatorcontrib><creatorcontrib>Halmos, G.B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bras, L.</au><au>Peters, T.T.A.</au><au>Wedman, J.</au><au>Plaat, B.E.C.</au><au>Witjes, M.J.H.</au><au>van Leeuwen, B.L.</au><au>van der Laan, B.F.A.M.</au><au>Halmos, G.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of the Groningen Frailty Indicator for treatment outcomes in elderly patients after head and neck, or skin cancer surgery in a retrospective cohort</atitle><jtitle>Clinical otolaryngology</jtitle><addtitle>Clin Otolaryngol</addtitle><date>2015-10</date><risdate>2015</risdate><volume>40</volume><issue>5</issue><spage>474</spage><epage>482</epage><pages>474-482</pages><issn>1749-4478</issn><eissn>1749-4486</eissn><abstract>Objectives
Careful selection of patients eligible for extensive head and neck cancer surgery is extremely important. A reliable predictor for postoperative outcomes in the vulnerable elderly population is not yet available. The concept of frailty describes a clinical state of increased vulnerability and can be assessed using frailty tests, such as the Groningen Frailty Indicator. In the current study, the influence of Groningen Frailty Indicator‐measured frailty on clinical outcome was investigated in elderly patients surgically treated for head and neck cancer.
Design
Retrospective, explorative cohort study.
Setting
Tertiary referral centre.
Participants
A total of 90 patients of 65 years and older receiving surgical treatment for head and neck cancer with different primary sites.
Main outcome measures
The influence of frailty (Groningen Frailty Indicator) on postoperative complications (Clavien–Dindo classification), subjective postoperative experience of both patient and surgeon and survival were analysed.
Results
A total of 36 patients were considered as frail (40%). Postoperative complications could not be predicted by frailty status. However, the Groningen Frailty Indicator dimension ‘health problems’ was a significant predictor for postoperative complications (P = 0.020). Unlike age and comorbidity, frailty was associated with a poor subjective patients’ experience of the postoperative recovery (P < 0.01). Although not statistically significant, survival analysis showed a worse 5‐year overall survival in the frail group (33%) versus the non‐frail group (74%).
Conclusions
Analysis of frailty could identify elderly patients who might suffer more than expected during the postoperative period after head and neck cancer surgery. In this study, frailty was not identified as a new predictor of complications after head and neck cancer surgery.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25754107</pmid><doi>10.1111/coa.12409</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1749-4478 |
| ispartof | Clinical otolaryngology, 2015-10, Vol.40 (5), p.474-482 |
| issn | 1749-4478 1749-4486 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Analysis of Variance Female Frail Elderly Head and Neck Neoplasms - mortality Head and Neck Neoplasms - surgery Humans Kaplan-Meier Estimate Male Neoplasm Staging Postoperative Complications Prognosis Retrospective Studies Skin Neoplasms - mortality Skin Neoplasms - surgery Treatment Outcome |
| title | Predictive value of the Groningen Frailty Indicator for treatment outcomes in elderly patients after head and neck, or skin cancer surgery in a retrospective cohort |
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