Mouse pancreatic beta cells express MHC class II and stimulate CD4+ T cells to proliferate

Type 1 diabetes results from destruction of pancreatic beta cells by autoreactive T cells. Both CD4+ and CD8+ T cells have been shown to mediate beta‐cell killing. While CD8+ T cells can directly recognize MHC class I on beta cells, the interaction between CD4+ T cells and beta cells remains unclear...

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Veröffentlicht in:	European journal of immunology 2015-09, Vol.45 (9), p.2494-2503
Hauptverfasser:	Zhao, Yuxing, Scott, Nicholas A., Quah, Hong Sheng, Krishnamurthy, Balasubramanian, Bond, Francene, Loudovaris, Thomas, Mannering, Stuart I., Kay, Thomas W. H., Thomas, Helen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diabetes · CD4+ T cells · MHC class II · Pancreatic beta cell CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Communication - immunology Cell Proliferation - drug effects Cells, Cultured Cytotoxicity, Immunologic Diabetes Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Female Gene expression Gene Expression Regulation HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Insulin Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - immunology Insulin-Secreting Cells - pathology Interferon-gamma - pharmacology Lymphocyte Activation - drug effects Lymphocytes Mice Mice, Inbred NOD Pancreas Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Tissue Culture Techniques
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